Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine
Recombinant Pseudomonas aeruginosa cells containing the Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as e...
Gespeichert in:
| Veröffentlicht in: | Veterinary microbiology 1987-09, Vol.14 (4), p.393-409 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 409 |
|---|---|
| container_issue | 4 |
| container_start_page | 393 |
| container_title | Veterinary microbiology |
| container_volume | 14 |
| creator | Egerton, J.R. Cox, P.T. Anderson, B.J. Kristo, C. Norman, M. Mattick, J.S. |
| description | Recombinant
Pseudomonas aeruginosa cells containing the
Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of
B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as either natural fimbriae or whole cell preparations of
B. nodosus in inducing protective immunity against homologous footrot challenge. The recombinant-produced fimbriae are also effective therapeutically in accelerating the rate of healing of pre-existing footrot lesions. These results confirm that the structural subunit of the fimbrial strand is a primary protective antigen against footrot, and demonstrate the practically and potential of recombinant DNA approaches to the development of new vaccines against
B. nodosus and other Type 4 fimbriate pathogens. |
| doi_str_mv | 10.1016/0378-1135(87)90030-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77850143</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0378113587900307</els_id><sourcerecordid>77850143</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-fed55ba821ff3ece251a61c0f127f184384ec7d1fa1d65e41945087e3d2ec2623</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhi3UChbKP6CSDxWCQ6jHdmLvBWnFVyshClJ7thxnXIySeLG9VP33zbKrPfY0h_d5R6NnCDkBdgEMmq9MKF0BiPpMq_M5Y4JVao_MQCtR8VryD2S2Qw7IYc4vjDE5b9g-2ed6DhzkjDw9pljQlRBHGj3Nz4hLan_bMOZCfYxliumfUJ6ppQldHNow2rHQ64dF1dqMHfVhaFOwPX2zzoURP5GP3vYZj7fziPy6vfl59a26_3H3_WpxXzmhm1J57Oq6tZqD9wId8hpsA4554MqDlkJLdKoDb6FrapQwlzXTCkXH0fGGiyNyutm7TPF1hbmYIWSHfW9HjKtslNI1AykmUG5Al2LOCb1ZpjDY9NcAM2uTZq3JrDUZrcy7SaOm2uft_lU7YLcrbdVN-ZdtbrOzvU92dCHvMKWmR2g9YZcbDCcXbwGTyS7g6LALk89iuhj-f8c_mxKO2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77850143</pqid></control><display><type>article</type><title>Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Egerton, J.R. ; Cox, P.T. ; Anderson, B.J. ; Kristo, C. ; Norman, M. ; Mattick, J.S.</creator><creatorcontrib>Egerton, J.R. ; Cox, P.T. ; Anderson, B.J. ; Kristo, C. ; Norman, M. ; Mattick, J.S.</creatorcontrib><description>Recombinant
Pseudomonas aeruginosa cells containing the
Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of
B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as either natural fimbriae or whole cell preparations of
B. nodosus in inducing protective immunity against homologous footrot challenge. The recombinant-produced fimbriae are also effective therapeutically in accelerating the rate of healing of pre-existing footrot lesions. These results confirm that the structural subunit of the fimbrial strand is a primary protective antigen against footrot, and demonstrate the practically and potential of recombinant DNA approaches to the development of new vaccines against
B. nodosus and other Type 4 fimbriate pathogens.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/0378-1135(87)90030-7</identifier><identifier>PMID: 2891214</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animal bacterial diseases ; Animals ; Antigens, Bacterial - analysis ; Bacterial diseases ; Bacterial Vaccines ; Bacteroides - genetics ; Bacteroides - immunology ; Biological and medical sciences ; DNA, Recombinant ; Fimbriae, Bacterial - immunology ; Foot Rot - prevention & control ; Genes, Bacterial ; Infectious diseases ; Male ; Medical sciences ; Pseudomonas aeruginosa - genetics ; Random Allocation ; Sheep ; Sheep Diseases - prevention & control ; Vaccination - veterinary ; Vaccines, Synthetic</subject><ispartof>Veterinary microbiology, 1987-09, Vol.14 (4), p.393-409</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-fed55ba821ff3ece251a61c0f127f184384ec7d1fa1d65e41945087e3d2ec2623</citedby><cites>FETCH-LOGICAL-c386t-fed55ba821ff3ece251a61c0f127f184384ec7d1fa1d65e41945087e3d2ec2623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1135(87)90030-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7718788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2891214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egerton, J.R.</creatorcontrib><creatorcontrib>Cox, P.T.</creatorcontrib><creatorcontrib>Anderson, B.J.</creatorcontrib><creatorcontrib>Kristo, C.</creatorcontrib><creatorcontrib>Norman, M.</creatorcontrib><creatorcontrib>Mattick, J.S.</creatorcontrib><title>Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>Recombinant
Pseudomonas aeruginosa cells containing the
Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of
B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as either natural fimbriae or whole cell preparations of
B. nodosus in inducing protective immunity against homologous footrot challenge. The recombinant-produced fimbriae are also effective therapeutically in accelerating the rate of healing of pre-existing footrot lesions. These results confirm that the structural subunit of the fimbrial strand is a primary protective antigen against footrot, and demonstrate the practically and potential of recombinant DNA approaches to the development of new vaccines against
B. nodosus and other Type 4 fimbriate pathogens.</description><subject>Animal bacterial diseases</subject><subject>Animals</subject><subject>Antigens, Bacterial - analysis</subject><subject>Bacterial diseases</subject><subject>Bacterial Vaccines</subject><subject>Bacteroides - genetics</subject><subject>Bacteroides - immunology</subject><subject>Biological and medical sciences</subject><subject>DNA, Recombinant</subject><subject>Fimbriae, Bacterial - immunology</subject><subject>Foot Rot - prevention & control</subject><subject>Genes, Bacterial</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pseudomonas aeruginosa - genetics</subject><subject>Random Allocation</subject><subject>Sheep</subject><subject>Sheep Diseases - prevention & control</subject><subject>Vaccination - veterinary</subject><subject>Vaccines, Synthetic</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhi3UChbKP6CSDxWCQ6jHdmLvBWnFVyshClJ7thxnXIySeLG9VP33zbKrPfY0h_d5R6NnCDkBdgEMmq9MKF0BiPpMq_M5Y4JVao_MQCtR8VryD2S2Qw7IYc4vjDE5b9g-2ed6DhzkjDw9pljQlRBHGj3Nz4hLan_bMOZCfYxliumfUJ6ppQldHNow2rHQ64dF1dqMHfVhaFOwPX2zzoURP5GP3vYZj7fziPy6vfl59a26_3H3_WpxXzmhm1J57Oq6tZqD9wId8hpsA4554MqDlkJLdKoDb6FrapQwlzXTCkXH0fGGiyNyutm7TPF1hbmYIWSHfW9HjKtslNI1AykmUG5Al2LOCb1ZpjDY9NcAM2uTZq3JrDUZrcy7SaOm2uft_lU7YLcrbdVN-ZdtbrOzvU92dCHvMKWmR2g9YZcbDCcXbwGTyS7g6LALk89iuhj-f8c_mxKO2A</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>Egerton, J.R.</creator><creator>Cox, P.T.</creator><creator>Anderson, B.J.</creator><creator>Kristo, C.</creator><creator>Norman, M.</creator><creator>Mattick, J.S.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870901</creationdate><title>Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine</title><author>Egerton, J.R. ; Cox, P.T. ; Anderson, B.J. ; Kristo, C. ; Norman, M. ; Mattick, J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-fed55ba821ff3ece251a61c0f127f184384ec7d1fa1d65e41945087e3d2ec2623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animal bacterial diseases</topic><topic>Animals</topic><topic>Antigens, Bacterial - analysis</topic><topic>Bacterial diseases</topic><topic>Bacterial Vaccines</topic><topic>Bacteroides - genetics</topic><topic>Bacteroides - immunology</topic><topic>Biological and medical sciences</topic><topic>DNA, Recombinant</topic><topic>Fimbriae, Bacterial - immunology</topic><topic>Foot Rot - prevention & control</topic><topic>Genes, Bacterial</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pseudomonas aeruginosa - genetics</topic><topic>Random Allocation</topic><topic>Sheep</topic><topic>Sheep Diseases - prevention & control</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, Synthetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egerton, J.R.</creatorcontrib><creatorcontrib>Cox, P.T.</creatorcontrib><creatorcontrib>Anderson, B.J.</creatorcontrib><creatorcontrib>Kristo, C.</creatorcontrib><creatorcontrib>Norman, M.</creatorcontrib><creatorcontrib>Mattick, J.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egerton, J.R.</au><au>Cox, P.T.</au><au>Anderson, B.J.</au><au>Kristo, C.</au><au>Norman, M.</au><au>Mattick, J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>14</volume><issue>4</issue><spage>393</spage><epage>409</epage><pages>393-409</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>Recombinant
Pseudomonas aeruginosa cells containing the
Bacteroides nodosus fimbrial subunit gene under the transcriptional control of a strong promoter produce large amounts of
B. nodosus-type fimbriae. We have carried out vaccination trials which show that these fimbriae are just as effective as either natural fimbriae or whole cell preparations of
B. nodosus in inducing protective immunity against homologous footrot challenge. The recombinant-produced fimbriae are also effective therapeutically in accelerating the rate of healing of pre-existing footrot lesions. These results confirm that the structural subunit of the fimbrial strand is a primary protective antigen against footrot, and demonstrate the practically and potential of recombinant DNA approaches to the development of new vaccines against
B. nodosus and other Type 4 fimbriate pathogens.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2891214</pmid><doi>10.1016/0378-1135(87)90030-7</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1135 |
| ispartof | Veterinary microbiology, 1987-09, Vol.14 (4), p.393-409 |
| issn | 0378-1135 1873-2542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77850143 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal bacterial diseases Animals Antigens, Bacterial - analysis Bacterial diseases Bacterial Vaccines Bacteroides - genetics Bacteroides - immunology Biological and medical sciences DNA, Recombinant Fimbriae, Bacterial - immunology Foot Rot - prevention & control Genes, Bacterial Infectious diseases Male Medical sciences Pseudomonas aeruginosa - genetics Random Allocation Sheep Sheep Diseases - prevention & control Vaccination - veterinary Vaccines, Synthetic |
| title | Protection of sheep against footrot with a recombinant DNA-based fimbrial vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T00%3A15%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protection%20of%20sheep%20against%20footrot%20with%20a%20recombinant%20DNA-based%20fimbrial%20vaccine&rft.jtitle=Veterinary%20microbiology&rft.au=Egerton,%20J.R.&rft.date=1987-09-01&rft.volume=14&rft.issue=4&rft.spage=393&rft.epage=409&rft.pages=393-409&rft.issn=0378-1135&rft.eissn=1873-2542&rft.coden=VMICDQ&rft_id=info:doi/10.1016/0378-1135(87)90030-7&rft_dat=%3Cproquest_cross%3E77850143%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77850143&rft_id=info:pmid/2891214&rft_els_id=0378113587900307&rfr_iscdi=true |