Effect of insulin on endocrine pancreas function during late pregnancy in the rat
To partly or completely satisfy the increasing demand for insulin, pregnant rats were infused SC with human insulin (2.4 or 4.8 IU/day) from day 14 to day 20 of gestation. Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hy...
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| Veröffentlicht in: | Physiology & behavior 1995-09, Vol.58 (3), p.445-450 |
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| creator | Wijkstra, Sonja Moes, Henk Schuiling, Gerard A. Koiter, Tjardus R. |
| description | To partly or completely satisfy the increasing demand for insulin, pregnant rats were infused SC with human insulin (2.4 or 4.8 IU/day) from day 14 to day 20 of gestation. Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but foetal survival was not affected. The low dose treatment prevented the characteristic rise of the insulin response to a glucose challenge during pregnancy, both in vivo and in vitro, while the high dose treatment suppressed the insulin response, as well as the pancreatic insulin content. The insulin responses and insulin contents of pregnant rats were higher than those of the corresponding cyclic control rats. These results support the hypothesis that during gestation the increased insulin demand, due to the actions of placental hormones, is the cause of the increased insulin secretion. However, it cannot be excluded that direct effects of placental hormones on the islets of Langerhans are also involved. |
| doi_str_mv | 10.1016/0031-9384(95)00080-3 |
| format | Article |
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Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but foetal survival was not affected. The low dose treatment prevented the characteristic rise of the insulin response to a glucose challenge during pregnancy, both in vivo and in vitro, while the high dose treatment suppressed the insulin response, as well as the pancreatic insulin content. The insulin responses and insulin contents of pregnant rats were higher than those of the corresponding cyclic control rats. These results support the hypothesis that during gestation the increased insulin demand, due to the actions of placental hormones, is the cause of the increased insulin secretion. However, it cannot be excluded that direct effects of placental hormones on the islets of Langerhans are also involved.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(95)00080-3</identifier><identifier>PMID: 8587950</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Weight - drug effects ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Glucagon secretion ; Glucose tolerance ; Glucose Tolerance Test ; Hormone metabolism and regulation ; Hyperinsulinaemia ; Insulin - pharmacology ; Insulin - physiology ; Insulin demand ; Insulin Infusion Systems ; Insulin secretion ; Islets of Langerhans - drug effects ; Islets of Langerhans - physiology ; Litter Size - drug effects ; Placental Hormones - physiology ; Pregnancy ; Pregnancy, Animal - drug effects ; Pregnancy, Animal - physiology ; Pregnancy. Parturition. 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Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but foetal survival was not affected. The low dose treatment prevented the characteristic rise of the insulin response to a glucose challenge during pregnancy, both in vivo and in vitro, while the high dose treatment suppressed the insulin response, as well as the pancreatic insulin content. The insulin responses and insulin contents of pregnant rats were higher than those of the corresponding cyclic control rats. These results support the hypothesis that during gestation the increased insulin demand, due to the actions of placental hormones, is the cause of the increased insulin secretion. However, it cannot be excluded that direct effects of placental hormones on the islets of Langerhans are also involved.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Glucagon secretion</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Hormone metabolism and regulation</subject><subject>Hyperinsulinaemia</subject><subject>Insulin - pharmacology</subject><subject>Insulin - physiology</subject><subject>Insulin demand</subject><subject>Insulin Infusion Systems</subject><subject>Insulin secretion</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - physiology</subject><subject>Litter Size - drug effects</subject><subject>Placental Hormones - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>Pregnancy, Animal - physiology</subject><subject>Pregnancy. Parturition. 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Psychology</topic><topic>Gestational Age</topic><topic>Glucagon secretion</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Hormone metabolism and regulation</topic><topic>Hyperinsulinaemia</topic><topic>Insulin - pharmacology</topic><topic>Insulin - physiology</topic><topic>Insulin demand</topic><topic>Insulin Infusion Systems</topic><topic>Insulin secretion</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - physiology</topic><topic>Litter Size - drug effects</topic><topic>Placental Hormones - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>Pregnancy, Animal - physiology</topic><topic>Pregnancy. Parturition. 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Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but foetal survival was not affected. The low dose treatment prevented the characteristic rise of the insulin response to a glucose challenge during pregnancy, both in vivo and in vitro, while the high dose treatment suppressed the insulin response, as well as the pancreatic insulin content. The insulin responses and insulin contents of pregnant rats were higher than those of the corresponding cyclic control rats. These results support the hypothesis that during gestation the increased insulin demand, due to the actions of placental hormones, is the cause of the increased insulin secretion. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Blood Glucose - metabolism Body Weight - drug effects Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Gestational Age Glucagon secretion Glucose tolerance Glucose Tolerance Test Hormone metabolism and regulation Hyperinsulinaemia Insulin - pharmacology Insulin - physiology Insulin demand Insulin Infusion Systems Insulin secretion Islets of Langerhans - drug effects Islets of Langerhans - physiology Litter Size - drug effects Placental Hormones - physiology Pregnancy Pregnancy, Animal - drug effects Pregnancy, Animal - physiology Pregnancy. Parturition. Lactation Rat Rats Rats, Wistar Vertebrates: reproduction |
| title | Effect of insulin on endocrine pancreas function during late pregnancy in the rat |
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