Architectural changes of the cortico-spinal system in the dystrophin defective mdx mouse
The mutant mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord...
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| Veröffentlicht in: | Neuroscience letters 1995-11, Vol.200 (1), p.53-56 |
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| creator | Sbriccoli, Alessandro Santarelli, Marialaura Carretta, Donatella Pinto, Francesco Granato, Alberto Minciacchi, Diego |
| description | The mutant
mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in
mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord of mutant and control mice. The tangential and radial distribution of CS labeled neurons were similar in
mdx and normal mice. Conversely, the absolute number and the cell packing density of labeled CS neurons were considerably lower in
mdx than in controls. In
mdx, the average size of CS cell was smaller while the perikaryal sizes displayed a normal distribution. In addition, CS neurons of
mdx appeared round-shaped compared to the pyramidal cells labeled in control animals. The structural modifications described here should prompt a reconsideration of the involvement of central nervous system in the dystrophin deficient
mdx mice. |
| doi_str_mv | 10.1016/0304-3940(95)12079-J |
| format | Article |
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mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in
mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord of mutant and control mice. The tangential and radial distribution of CS labeled neurons were similar in
mdx and normal mice. Conversely, the absolute number and the cell packing density of labeled CS neurons were considerably lower in
mdx than in controls. In
mdx, the average size of CS cell was smaller while the perikaryal sizes displayed a normal distribution. In addition, CS neurons of
mdx appeared round-shaped compared to the pyramidal cells labeled in control animals. The structural modifications described here should prompt a reconsideration of the involvement of central nervous system in the dystrophin deficient
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mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in
mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord of mutant and control mice. The tangential and radial distribution of CS labeled neurons were similar in
mdx and normal mice. Conversely, the absolute number and the cell packing density of labeled CS neurons were considerably lower in
mdx than in controls. In
mdx, the average size of CS cell was smaller while the perikaryal sizes displayed a normal distribution. In addition, CS neurons of
mdx appeared round-shaped compared to the pyramidal cells labeled in control animals. The structural modifications described here should prompt a reconsideration of the involvement of central nervous system in the dystrophin deficient
mdx mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Cerebral Cortex - pathology</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Histocytochemistry</subject><subject>Horseradish peroxidase</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Motor control</subject><subject>Muscular dystrophy</subject><subject>Muscular Dystrophy, Animal - pathology</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Pyramidal tract</subject><subject>Sensorimotor cortex</subject><subject>Spinal Cord - pathology</subject><subject>Spinal motoneurons</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMoWi9voDALEV2MJjO5boQi3krBTRfuQpqcsZG51GRa9O1NL3Spq-Twf-fn8CF0TvAtwYTf4RLTvFQUXyt2QwosVD7aQwMiRZELJYp9NNghR-g4xk-MMSOMHqJDySQtOB-g92GwM9-D7RfB1JmdmfYDYtZVWT-DzHah97bL49y3KY0_sYcm8-06dGkK3XyWRgdVavBLyBr3nTXdIsIpOqhMHeFs-56gydPj5OElH789vz4Mx7ktZdnnlbXGSOBUCS5LoMVUUCwdccLxqpxOVfpQIoxQRhUVVarAJWecW2YYkbY8QVeb2nnovhYQe934aKGuTQvpDC2EpEIK8S9IBCaSK5ZAugFt6GIMUOl58I0JP5pgvRKvV1b1yqpWTK_F61Fau9j2L6YNuN3S1nTKL7e5idbUVTCt9XGHFYpIpVbY_QaD5GzpIehoPbQWnA9JsXad__uOX_3Wn1s</recordid><startdate>19951110</startdate><enddate>19951110</enddate><creator>Sbriccoli, Alessandro</creator><creator>Santarelli, Marialaura</creator><creator>Carretta, Donatella</creator><creator>Pinto, Francesco</creator><creator>Granato, Alberto</creator><creator>Minciacchi, Diego</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19951110</creationdate><title>Architectural changes of the cortico-spinal system in the dystrophin defective mdx mouse</title><author>Sbriccoli, Alessandro ; Santarelli, Marialaura ; Carretta, Donatella ; Pinto, Francesco ; Granato, Alberto ; Minciacchi, Diego</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-fccaa8e6497683e42b7408d1d7d6f3bb9d7d417a79a92f4992036566c5a518c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Cerebral Cortex - pathology</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Histocytochemistry</topic><topic>Horseradish peroxidase</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Motor control</topic><topic>Muscular dystrophy</topic><topic>Muscular Dystrophy, Animal - pathology</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Pyramidal tract</topic><topic>Sensorimotor cortex</topic><topic>Spinal Cord - pathology</topic><topic>Spinal motoneurons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sbriccoli, Alessandro</creatorcontrib><creatorcontrib>Santarelli, Marialaura</creatorcontrib><creatorcontrib>Carretta, Donatella</creatorcontrib><creatorcontrib>Pinto, Francesco</creatorcontrib><creatorcontrib>Granato, Alberto</creatorcontrib><creatorcontrib>Minciacchi, Diego</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sbriccoli, Alessandro</au><au>Santarelli, Marialaura</au><au>Carretta, Donatella</au><au>Pinto, Francesco</au><au>Granato, Alberto</au><au>Minciacchi, Diego</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Architectural changes of the cortico-spinal system in the dystrophin defective mdx mouse</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1995-11-10</date><risdate>1995</risdate><volume>200</volume><issue>1</issue><spage>53</spage><epage>56</epage><pages>53-56</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The mutant
mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in
mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord of mutant and control mice. The tangential and radial distribution of CS labeled neurons were similar in
mdx and normal mice. Conversely, the absolute number and the cell packing density of labeled CS neurons were considerably lower in
mdx than in controls. In
mdx, the average size of CS cell was smaller while the perikaryal sizes displayed a normal distribution. In addition, CS neurons of
mdx appeared round-shaped compared to the pyramidal cells labeled in control animals. The structural modifications described here should prompt a reconsideration of the involvement of central nervous system in the dystrophin deficient
mdx mice.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8584266</pmid><doi>10.1016/0304-3940(95)12079-J</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1995-11, Vol.200 (1), p.53-56 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Count Cerebral Cortex - pathology Diseases of striated muscles. Neuromuscular diseases Histocytochemistry Horseradish peroxidase Medical sciences Mice Mice, Mutant Strains Motor control Muscular dystrophy Muscular Dystrophy, Animal - pathology Neurology Neurons - pathology Pyramidal tract Sensorimotor cortex Spinal Cord - pathology Spinal motoneurons |
| title | Architectural changes of the cortico-spinal system in the dystrophin defective mdx mouse |
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