Tumor Cell Rejection through Terminal Cell Differentiation
Leukemic cells cultured in the presence of various conditioned media differentiate into macrophages. This finding suggested that the maintenance of undifferentiated state and self-renewal in vivo may be related to the inability of the host to generate an appropriate level of differentiation factor (...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1987-11, Vol.238 (4831), p.1278-1280 |
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| creator | Jimenez, Joaquin J. Yunis, Adel A. |
| description | Leukemic cells cultured in the presence of various conditioned media differentiate into macrophages. This finding suggested that the maintenance of undifferentiated state and self-renewal in vivo may be related to the inability of the host to generate an appropriate level of differentiation factor (DF). Evidence for this hypothesis was derived from experiments in vitro and in vivo with myeloid leukemia of rat. The following results were obtained: (i) in vitro, the percentage of cell differentiation at a fixed concentration of DF was inversely related to the concentration of cells; (ii) leukemic cell inoculates that were lethal to 7-day-old rats were rejected by 21-day-old rats; (iii) leukemic cells in diffusion chambers underwent differentiation in 21-day-old rats but not in 7-day-old rats; (iv) organs from 21-day-old rats contained more DF activity than those of 7-day-old rats; (v) treatment of rats with DF in diffusion chambers resulted in leukemic cell differentiation inside the chamber; and (vi) the development of leukemia in 7-day-old rats was aborted by treatment with DF. These results show that the differentiation of rat leukemia cells requires the appropriate level of DF. The proliferation of transplanted leukemia cells in 7-day-old rats goes unchecked because of inadequate generation of DF. Conversely, in the 21-day-old rats, rejection is accomplished by differentiation of the transplanted cells. |
| doi_str_mv | 10.1126/science.3685979 |
| format | Article |
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This finding suggested that the maintenance of undifferentiated state and self-renewal in vivo may be related to the inability of the host to generate an appropriate level of differentiation factor (DF). Evidence for this hypothesis was derived from experiments in vitro and in vivo with myeloid leukemia of rat. The following results were obtained: (i) in vitro, the percentage of cell differentiation at a fixed concentration of DF was inversely related to the concentration of cells; (ii) leukemic cell inoculates that were lethal to 7-day-old rats were rejected by 21-day-old rats; (iii) leukemic cells in diffusion chambers underwent differentiation in 21-day-old rats but not in 7-day-old rats; (iv) organs from 21-day-old rats contained more DF activity than those of 7-day-old rats; (v) treatment of rats with DF in diffusion chambers resulted in leukemic cell differentiation inside the chamber; and (vi) the development of leukemia in 7-day-old rats was aborted by treatment with DF. These results show that the differentiation of rat leukemia cells requires the appropriate level of DF. The proliferation of transplanted leukemia cells in 7-day-old rats goes unchecked because of inadequate generation of DF. Conversely, in the 21-day-old rats, rejection is accomplished by differentiation of the transplanted cells.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3685979</identifier><identifier>PMID: 3685979</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animal tumors. Experimental tumors ; Animals ; Animals, Newborn ; Biochemistry ; Biological and medical sciences ; Cell Differentiation ; Cell Division ; Cell growth ; Cell Line ; Cell lines ; Cell Survival ; Cell transplantation ; Cellular differentiation ; Colony-stimulating factors ; Colony-stimulating factors (Physiology) ; Experimental malignant blood diseases ; Genetics ; Graft Rejection ; Leukemia ; Leukemia, Experimental - pathology ; Medical sciences ; Myelocytic leukemia ; Myeloid leukemia ; Neoplasm Transplantation ; Nonlymphoid leukemia ; Oncology ; Phagocytosis ; Rats ; Stem cell transplantation ; Stem cells ; Tumors</subject><ispartof>Science (American Association for the Advancement of Science), 1987-11, Vol.238 (4831), p.1278-1280</ispartof><rights>Copyright 1987 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 27, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-3c1dfdf134b6f3e459d4752b6df781bb1dd242a3c2f60d0aab6d433c67a9a393</citedby><cites>FETCH-LOGICAL-c699t-3c1dfdf134b6f3e459d4752b6df781bb1dd242a3c2f60d0aab6d433c67a9a393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1700809$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1700809$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7565502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3685979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jimenez, Joaquin J.</creatorcontrib><creatorcontrib>Yunis, Adel A.</creatorcontrib><title>Tumor Cell Rejection through Terminal Cell Differentiation</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Leukemic cells cultured in the presence of various conditioned media differentiate into macrophages. This finding suggested that the maintenance of undifferentiated state and self-renewal in vivo may be related to the inability of the host to generate an appropriate level of differentiation factor (DF). Evidence for this hypothesis was derived from experiments in vitro and in vivo with myeloid leukemia of rat. The following results were obtained: (i) in vitro, the percentage of cell differentiation at a fixed concentration of DF was inversely related to the concentration of cells; (ii) leukemic cell inoculates that were lethal to 7-day-old rats were rejected by 21-day-old rats; (iii) leukemic cells in diffusion chambers underwent differentiation in 21-day-old rats but not in 7-day-old rats; (iv) organs from 21-day-old rats contained more DF activity than those of 7-day-old rats; (v) treatment of rats with DF in diffusion chambers resulted in leukemic cell differentiation inside the chamber; and (vi) the development of leukemia in 7-day-old rats was aborted by treatment with DF. These results show that the differentiation of rat leukemia cells requires the appropriate level of DF. The proliferation of transplanted leukemia cells in 7-day-old rats goes unchecked because of inadequate generation of DF. Conversely, in the 21-day-old rats, rejection is accomplished by differentiation of the transplanted cells.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell Survival</subject><subject>Cell transplantation</subject><subject>Cellular differentiation</subject><subject>Colony-stimulating factors</subject><subject>Colony-stimulating factors (Physiology)</subject><subject>Experimental malignant blood diseases</subject><subject>Genetics</subject><subject>Graft Rejection</subject><subject>Leukemia</subject><subject>Leukemia, Experimental - pathology</subject><subject>Medical sciences</subject><subject>Myelocytic leukemia</subject><subject>Myeloid leukemia</subject><subject>Neoplasm Transplantation</subject><subject>Nonlymphoid leukemia</subject><subject>Oncology</subject><subject>Phagocytosis</subject><subject>Rats</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Tumors</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1rFDEYB-BBlLqtnr0oLKXooW6bj0ky8VZXXQuLC7p4DZnMm2mWmUlNZkD_e7Ps0FZZ6JJDIL8nH-R9s-wVRhcYE34ZjYPOwAXlBZNCPskmGEk2kwTRp9kEIcpnBRLseXYc4wahlEl6lB2NfJJ9WA-tD9M5NM30O2zA9M530_4m-KG-ma4htK7TzS7_5KyFAF3v9Fa9yJ5Z3UR4Oc4n2frL5_X862y5WlzPr5Yzw6XsZ9TgylYW07zklkLOZJULRkpeWVHgssRVRXKiqSGWowppnZKcUsOFlppKepK93R17G_yvAWKvWhdNeo_uwA9RCVHkgrLiUUg5kUjm5FGIGaKScZHg6X9w44eQ_iMqgikj6Ze36HyHat2Acp31fdCmhg6CbnwH1qXlK542kIIl_X6PTqOC1pk9_N0_PIkefve1HmJU1z--HSpXPw-VHxcHymKxfCjP90njmwZqUKkf5quH-nKnTfAxBrDqNrhWhz8KI7VtazW2tRr7NO14M1ZiKFuo7vx9fjbmOhrd2KA74-IdE4wzhraVf71jm9j7cH-rQKhAkv4FDngFBQ</recordid><startdate>19871127</startdate><enddate>19871127</enddate><creator>Jimenez, Joaquin J.</creator><creator>Yunis, Adel A.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19871127</creationdate><title>Tumor Cell Rejection through Terminal Cell Differentiation</title><author>Jimenez, Joaquin J. ; Yunis, Adel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c699t-3c1dfdf134b6f3e459d4752b6df781bb1dd242a3c2f60d0aab6d433c67a9a393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell Survival</topic><topic>Cell transplantation</topic><topic>Cellular differentiation</topic><topic>Colony-stimulating factors</topic><topic>Colony-stimulating factors (Physiology)</topic><topic>Experimental malignant blood diseases</topic><topic>Genetics</topic><topic>Graft Rejection</topic><topic>Leukemia</topic><topic>Leukemia, Experimental - pathology</topic><topic>Medical sciences</topic><topic>Myelocytic leukemia</topic><topic>Myeloid leukemia</topic><topic>Neoplasm Transplantation</topic><topic>Nonlymphoid leukemia</topic><topic>Oncology</topic><topic>Phagocytosis</topic><topic>Rats</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jimenez, Joaquin J.</creatorcontrib><creatorcontrib>Yunis, Adel A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jimenez, Joaquin J.</au><au>Yunis, Adel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor Cell Rejection through Terminal Cell Differentiation</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1987-11-27</date><risdate>1987</risdate><volume>238</volume><issue>4831</issue><spage>1278</spage><epage>1280</epage><pages>1278-1280</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Leukemic cells cultured in the presence of various conditioned media differentiate into macrophages. This finding suggested that the maintenance of undifferentiated state and self-renewal in vivo may be related to the inability of the host to generate an appropriate level of differentiation factor (DF). Evidence for this hypothesis was derived from experiments in vitro and in vivo with myeloid leukemia of rat. The following results were obtained: (i) in vitro, the percentage of cell differentiation at a fixed concentration of DF was inversely related to the concentration of cells; (ii) leukemic cell inoculates that were lethal to 7-day-old rats were rejected by 21-day-old rats; (iii) leukemic cells in diffusion chambers underwent differentiation in 21-day-old rats but not in 7-day-old rats; (iv) organs from 21-day-old rats contained more DF activity than those of 7-day-old rats; (v) treatment of rats with DF in diffusion chambers resulted in leukemic cell differentiation inside the chamber; and (vi) the development of leukemia in 7-day-old rats was aborted by treatment with DF. These results show that the differentiation of rat leukemia cells requires the appropriate level of DF. The proliferation of transplanted leukemia cells in 7-day-old rats goes unchecked because of inadequate generation of DF. Conversely, in the 21-day-old rats, rejection is accomplished by differentiation of the transplanted cells.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3685979</pmid><doi>10.1126/science.3685979</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1987-11, Vol.238 (4831), p.1278-1280 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77847358 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animal tumors. Experimental tumors Animals Animals, Newborn Biochemistry Biological and medical sciences Cell Differentiation Cell Division Cell growth Cell Line Cell lines Cell Survival Cell transplantation Cellular differentiation Colony-stimulating factors Colony-stimulating factors (Physiology) Experimental malignant blood diseases Genetics Graft Rejection Leukemia Leukemia, Experimental - pathology Medical sciences Myelocytic leukemia Myeloid leukemia Neoplasm Transplantation Nonlymphoid leukemia Oncology Phagocytosis Rats Stem cell transplantation Stem cells Tumors |
| title | Tumor Cell Rejection through Terminal Cell Differentiation |
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