The effects of dietary supplementation with fish oil in patients with psoriasis
SUMMARY Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal...
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| Veröffentlicht in: | British journal of dermatology (1951) 1987-11, Vol.117 (5), p.599-606 |
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| container_title | British journal of dermatology (1951) |
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| creator | MAURICE, P.D.L. ALLEN, B.R. BARKLEY, A.S.J. COCKBILL, S.R. STAMMERS, J. BATHER, P.C. |
| description | SUMMARY
Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling. The dietary treatment resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro. The discrepancy between the high degree of inhibition of leukotriene B4 synthesis and the modest therapeutic effect suggests that leukotriene B4 is not the only mediator involved in the development of the psoriatic lesion. Furthermore, the in vivo cutaneous levels of leukotriene B4 might not have been inhibited to the same extent as the polymorphonuclear leukocyte levels in vitro.
Further studies on the use of fish oil supplements, both on their own and in conjunction with other forms of treatment in psoriasis are warranted. It will also be important to determine whether the altered profile of 5‐lipoxygcnase products found in the blood is also seen in the skin. |
| doi_str_mv | 10.1111/j.1365-2133.1987.tb07492.x |
| format | Article |
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Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling. The dietary treatment resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro. The discrepancy between the high degree of inhibition of leukotriene B4 synthesis and the modest therapeutic effect suggests that leukotriene B4 is not the only mediator involved in the development of the psoriatic lesion. Furthermore, the in vivo cutaneous levels of leukotriene B4 might not have been inhibited to the same extent as the polymorphonuclear leukocyte levels in vitro.
Further studies on the use of fish oil supplements, both on their own and in conjunction with other forms of treatment in psoriasis are warranted. It will also be important to determine whether the altered profile of 5‐lipoxygcnase products found in the blood is also seen in the skin.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1987.tb07492.x</identifier><identifier>PMID: 3689678</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Arachidonate 5-Lipoxygenase - blood ; Biological and medical sciences ; Blood Platelets - metabolism ; Chromatography, High Pressure Liquid ; Dermatology ; Dietary Fats, Unsaturated - therapeutic use ; Docosahexaenoic Acids ; Drug Combinations ; Eicosapentaenoic Acid ; Fatty Acids - blood ; Fatty Acids, Unsaturated - therapeutic use ; Female ; Fish Oils - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Neutrophils - enzymology ; Psoriasis - blood ; Psoriasis - diet therapy ; Psoriasis. Parapsoriasis. Lichen ; Thromboxane B2 - blood</subject><ispartof>British journal of dermatology (1951), 1987-11, Vol.117 (5), p.599-606</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4369-3ca3ef2d35987fc225e3565485a84bf426a96933083a90343a137057d84a41b53</citedby><cites>FETCH-LOGICAL-c4369-3ca3ef2d35987fc225e3565485a84bf426a96933083a90343a137057d84a41b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1987.tb07492.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1987.tb07492.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7394584$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3689678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAURICE, P.D.L.</creatorcontrib><creatorcontrib>ALLEN, B.R.</creatorcontrib><creatorcontrib>BARKLEY, A.S.J.</creatorcontrib><creatorcontrib>COCKBILL, S.R.</creatorcontrib><creatorcontrib>STAMMERS, J.</creatorcontrib><creatorcontrib>BATHER, P.C.</creatorcontrib><title>The effects of dietary supplementation with fish oil in patients with psoriasis</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling. The dietary treatment resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro. The discrepancy between the high degree of inhibition of leukotriene B4 synthesis and the modest therapeutic effect suggests that leukotriene B4 is not the only mediator involved in the development of the psoriatic lesion. Furthermore, the in vivo cutaneous levels of leukotriene B4 might not have been inhibited to the same extent as the polymorphonuclear leukocyte levels in vitro.
Further studies on the use of fish oil supplements, both on their own and in conjunction with other forms of treatment in psoriasis are warranted. It will also be important to determine whether the altered profile of 5‐lipoxygcnase products found in the blood is also seen in the skin.</description><subject>Adult</subject><subject>Arachidonate 5-Lipoxygenase - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dermatology</subject><subject>Dietary Fats, Unsaturated - therapeutic use</subject><subject>Docosahexaenoic Acids</subject><subject>Drug Combinations</subject><subject>Eicosapentaenoic Acid</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Unsaturated - therapeutic use</subject><subject>Female</subject><subject>Fish Oils - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils - enzymology</subject><subject>Psoriasis - blood</subject><subject>Psoriasis - diet therapy</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Thromboxane B2 - blood</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9v1DAQxS0EKkvhIyBZCHFLsDP-ywEJulAoFVVREdwsb9bWeskmIZNVt98erxLtHV9G8nvzZuZHyCvOSp7f223JQcmi4gAlt0aX44ppYavy8IgsTtJjsmCM6YJZBU_JM8QtYxyYZGfkDJSxSpsFubnbBBpiDPWItIt0ncLohweK-75vwi60ox9T19L7NG5oTLihXWpoammf_7OKk9JjNySPCZ-TJ9E3GF7M9Zz8_Pzp7uJLcX1z-fXiw3VRC1C2gNpDiNUaZF4_1lUlA0glhZHeiFUUlfJWWQBmwFsGAjwHzaReG-EFX0k4J2-m3H7o_u4Djm6XsA5N49vQ7dFpbYTg3GTju8lYDx3iEKLrh7TLJzrO3JGm27ojMndE5o403UzTHXLzy3nKfrUL61PrjC_rr2fdY-2bOPi2TniyabBCGpFt7yfbfWrCw38s4D5eLaW1OaCYAhKO4XAK8MMfpzRo6X59v3RXyx-33_Ty1v2Gf7BMn_g</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>MAURICE, P.D.L.</creator><creator>ALLEN, B.R.</creator><creator>BARKLEY, A.S.J.</creator><creator>COCKBILL, S.R.</creator><creator>STAMMERS, J.</creator><creator>BATHER, P.C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198711</creationdate><title>The effects of dietary supplementation with fish oil in patients with psoriasis</title><author>MAURICE, P.D.L. ; ALLEN, B.R. ; BARKLEY, A.S.J. ; COCKBILL, S.R. ; STAMMERS, J. ; BATHER, P.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4369-3ca3ef2d35987fc225e3565485a84bf426a96933083a90343a137057d84a41b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Arachidonate 5-Lipoxygenase - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dermatology</topic><topic>Dietary Fats, Unsaturated - therapeutic use</topic><topic>Docosahexaenoic Acids</topic><topic>Drug Combinations</topic><topic>Eicosapentaenoic Acid</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Unsaturated - therapeutic use</topic><topic>Female</topic><topic>Fish Oils - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils - enzymology</topic><topic>Psoriasis - blood</topic><topic>Psoriasis - diet therapy</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Thromboxane B2 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAURICE, P.D.L.</creatorcontrib><creatorcontrib>ALLEN, B.R.</creatorcontrib><creatorcontrib>BARKLEY, A.S.J.</creatorcontrib><creatorcontrib>COCKBILL, S.R.</creatorcontrib><creatorcontrib>STAMMERS, J.</creatorcontrib><creatorcontrib>BATHER, P.C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAURICE, P.D.L.</au><au>ALLEN, B.R.</au><au>BARKLEY, A.S.J.</au><au>COCKBILL, S.R.</au><au>STAMMERS, J.</au><au>BATHER, P.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of dietary supplementation with fish oil in patients with psoriasis</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1987-11</date><risdate>1987</risdate><volume>117</volume><issue>5</issue><spage>599</spage><epage>606</epage><pages>599-606</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>SUMMARY
Ten patients with psoriasis resistant to conventional topical treatment were given dietary supplements of fish oil, providing approximately 12 g of eicosapentaenoic acid daily for a period of at least 6 weeks. In eight patients there was a modest improvement in their psoriasis, the principal effects being a diminution of erythema and scaling. The dietary treatment resulted in a substantial inhibition of leukotriene B4 production by the peripheral blood polymorphonuclear leukocytes in vitro. The discrepancy between the high degree of inhibition of leukotriene B4 synthesis and the modest therapeutic effect suggests that leukotriene B4 is not the only mediator involved in the development of the psoriatic lesion. Furthermore, the in vivo cutaneous levels of leukotriene B4 might not have been inhibited to the same extent as the polymorphonuclear leukocyte levels in vitro.
Further studies on the use of fish oil supplements, both on their own and in conjunction with other forms of treatment in psoriasis are warranted. It will also be important to determine whether the altered profile of 5‐lipoxygcnase products found in the blood is also seen in the skin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3689678</pmid><doi>10.1111/j.1365-2133.1987.tb07492.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 1987-11, Vol.117 (5), p.599-606 |
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| subjects | Adult Arachidonate 5-Lipoxygenase - blood Biological and medical sciences Blood Platelets - metabolism Chromatography, High Pressure Liquid Dermatology Dietary Fats, Unsaturated - therapeutic use Docosahexaenoic Acids Drug Combinations Eicosapentaenoic Acid Fatty Acids - blood Fatty Acids, Unsaturated - therapeutic use Female Fish Oils - therapeutic use Humans Male Medical sciences Middle Aged Neutrophils - enzymology Psoriasis - blood Psoriasis - diet therapy Psoriasis. Parapsoriasis. Lichen Thromboxane B2 - blood |
| title | The effects of dietary supplementation with fish oil in patients with psoriasis |
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