Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen
The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted fo...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1987-12, Vol.238 (4834), p.1704-1707 |
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| container_issue | 4834 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Smith, Douglas H. Byrn, Randal A. Marsters, Scot A. Gregory, Timothy Groopman, Jerome E. Capon, Daniel J. |
| description | The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS). |
| doi_str_mv | 10.1126/science.3500514 |
| format | Article |
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As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3500514</identifier><identifier>PMID: 3500514</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - immunology ; AIDS ; AIDS/HIV ; Animals ; Antigen presenting cells ; Antigens ; Antigens, Differentiation, T-Lymphocyte - immunology ; Antiviral drugs ; Biological and medical sciences ; Biotechnology ; Cell Line ; CHO cells ; Cultured cells ; Fundamental and applied biological sciences. Psychology ; Giant cells ; Glycoproteins ; Health care ; Health. Pharmaceutical industry ; HIV ; HIV (Viruses) ; HIV - immunology ; HIV - pathogenicity ; HIV - physiology ; HIV 1 ; Human immunodeficiency virus 1 ; Humans ; Immunology, Experimental ; Industrial applications and implications. Economical aspects ; Infections ; Microbiology ; Production of active biomolecules ; Protein research ; Receptors, Virus - immunology ; Receptors, Virus - physiology ; Recombinant Proteins - immunology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; T lymphocytes ; T-Lymphocytes - immunology ; Viral Envelope Proteins - immunology ; Viral Envelope Proteins - physiology ; Virology ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1987-12, Vol.238 (4834), p.1704-1707</ispartof><rights>Copyright 1987 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 18, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c796t-495ff706ced2ee72a65cd7ea995a3aa4277e757314b17e72fd745fda9d1e3f273</citedby><cites>FETCH-LOGICAL-c796t-495ff706ced2ee72a65cd7ea995a3aa4277e757314b17e72fd745fda9d1e3f273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1700644$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1700644$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7584750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3500514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Douglas H.</creatorcontrib><creatorcontrib>Byrn, Randal A.</creatorcontrib><creatorcontrib>Marsters, Scot A.</creatorcontrib><creatorcontrib>Gregory, Timothy</creatorcontrib><creatorcontrib>Groopman, Jerome E.</creatorcontrib><creatorcontrib>Capon, Daniel J.</creatorcontrib><title>Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antigen presenting cells</subject><subject>Antigens</subject><subject>Antigens, Differentiation, T-Lymphocyte - immunology</subject><subject>Antiviral drugs</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell Line</subject><subject>CHO cells</subject><subject>Cultured cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Giant cells</subject><subject>Glycoproteins</subject><subject>Health care</subject><subject>Health. Pharmaceutical industry</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV - immunology</subject><subject>HIV - pathogenicity</subject><subject>HIV - physiology</subject><subject>HIV 1</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunology, Experimental</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Infections</subject><subject>Microbiology</subject><subject>Production of active biomolecules</subject><subject>Protein research</subject><subject>Receptors, Virus - immunology</subject><subject>Receptors, Virus - physiology</subject><subject>Recombinant Proteins - immunology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Viral Envelope Proteins - immunology</subject><subject>Viral Envelope Proteins - physiology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN081v0zAUAPAIgUYZnLmAFE0IDls2f8bJsSusq1TRQ2HXyHWei4sbDztB9L_HVaNtoEqtfLDl9_Oz9PycJG8xusSY5FdBGWgUXFKOEMfsWTLAqORZSRB9ngwQonlWIMFfJq9CWCEUYyU9SU56Pkim19apn6ZZpk6nt5O7DKeTRoNqzW_TbtLFJpXp3NluYeEinYPy0EKd3ji_3h5of0A6-szSYdOaJTSvkxda2gBv-vk0-X7z5dvoNpvOxpPRcJopUeZtxkqutUC5gpoACCJzrmoBsiy5pFIyIgQILihmCxxXRNeCcV3LssZANRH0NPm4y3vv3a8OQlutTVBgrWzAdaESomCkFOwgjGUQJWX4ICQYc0zp4YyYFShHPI_w7D-4cp1vYlliMspJwQWK6HyHltJCZRrtWi9VrCR4aV0D2sTtYU44JoxGfbFHx1HD2qg9_NM_PIoW_rRL2YVQTeZfj5Wzu2Pl9fhIWYynT-X5PqmctbCEKnbOaPZUX-208i4ED7q692Yt_abCqNp-iar_ElXf4_HE-_4lusUa6gf_GP_Qx2VQ0movG2XCAxO8YIJv3-rdjq1C6_zjrQKhnDH6FxlxFgs</recordid><startdate>19871218</startdate><enddate>19871218</enddate><creator>Smith, Douglas H.</creator><creator>Byrn, Randal A.</creator><creator>Marsters, Scot A.</creator><creator>Gregory, Timothy</creator><creator>Groopman, Jerome E.</creator><creator>Capon, Daniel J.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19871218</creationdate><title>Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen</title><author>Smith, Douglas H. ; Byrn, Randal A. ; Marsters, Scot A. ; Gregory, Timothy ; Groopman, Jerome E. ; Capon, Daniel J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c796t-495ff706ced2ee72a65cd7ea995a3aa4277e757314b17e72fd745fda9d1e3f273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antigen presenting cells</topic><topic>Antigens</topic><topic>Antigens, Differentiation, T-Lymphocyte - immunology</topic><topic>Antiviral drugs</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cell Line</topic><topic>CHO cells</topic><topic>Cultured cells</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Giant cells</topic><topic>Glycoproteins</topic><topic>Health care</topic><topic>Health. Pharmaceutical industry</topic><topic>HIV</topic><topic>HIV (Viruses)</topic><topic>HIV - immunology</topic><topic>HIV - pathogenicity</topic><topic>HIV - physiology</topic><topic>HIV 1</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunology, Experimental</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Infections</topic><topic>Microbiology</topic><topic>Production of active biomolecules</topic><topic>Protein research</topic><topic>Receptors, Virus - immunology</topic><topic>Receptors, Virus - physiology</topic><topic>Recombinant Proteins - immunology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Viral Envelope Proteins - physiology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Douglas H.</creatorcontrib><creatorcontrib>Byrn, Randal A.</creatorcontrib><creatorcontrib>Marsters, Scot A.</creatorcontrib><creatorcontrib>Gregory, Timothy</creatorcontrib><creatorcontrib>Groopman, Jerome E.</creatorcontrib><creatorcontrib>Capon, Daniel J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Douglas H.</au><au>Byrn, Randal A.</au><au>Marsters, Scot A.</au><au>Gregory, Timothy</au><au>Groopman, Jerome E.</au><au>Capon, Daniel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1987-12-18</date><risdate>1987</risdate><volume>238</volume><issue>4834</issue><spage>1704</spage><epage>1707</epage><pages>1704-1707</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3500514</pmid><doi>10.1126/science.3500514</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1987-12, Vol.238 (4834), p.1704-1707 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77842974 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - immunology AIDS AIDS/HIV Animals Antigen presenting cells Antigens Antigens, Differentiation, T-Lymphocyte - immunology Antiviral drugs Biological and medical sciences Biotechnology Cell Line CHO cells Cultured cells Fundamental and applied biological sciences. Psychology Giant cells Glycoproteins Health care Health. Pharmaceutical industry HIV HIV (Viruses) HIV - immunology HIV - pathogenicity HIV - physiology HIV 1 Human immunodeficiency virus 1 Humans Immunology, Experimental Industrial applications and implications. Economical aspects Infections Microbiology Production of active biomolecules Protein research Receptors, Virus - immunology Receptors, Virus - physiology Recombinant Proteins - immunology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T lymphocytes T-Lymphocytes - immunology Viral Envelope Proteins - immunology Viral Envelope Proteins - physiology Virology Viruses |
| title | Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen |
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