Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate
The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of...
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| Veröffentlicht in: | The Prostate 1987, Vol.11 (4), p.305-311 |
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| container_title | The Prostate |
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| creator | De Voogt, H. J. Rao, B. R. Geldof, A. A. Gooren, L. J. G. Bouman, F. G. |
| description | The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl estradiol, prostate volumes again were not changed. However, histology revealed glandular atrophy and an increase in stromal tissue. The significance of these findings is discussed. |
| doi_str_mv | 10.1002/pros.2990110403 |
| format | Article |
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Psychology ; Hormone metabolism and regulation ; Humans ; Imidazoles - pharmacology ; Imidazolidines ; Luteinizing Hormone - blood ; Male ; Mammalian male genital system ; normal human prostate ; Prolactin - blood ; Prostate - anatomy & histology ; Prostate - cytology ; Prostate - drug effects ; Testosterone - blood ; Vertebrates: reproduction</subject><ispartof>The Prostate, 1987, Vol.11 (4), p.305-311</ispartof><rights>Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4113-5accf6950236d9f7db4e3fc95c631aff8505d5efa03d38aa0df2b1def4b8d80f3</citedby><cites>FETCH-LOGICAL-c4113-5accf6950236d9f7db4e3fc95c631aff8505d5efa03d38aa0df2b1def4b8d80f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.2990110403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.2990110403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7831799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2960959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Voogt, H. J.</creatorcontrib><creatorcontrib>Rao, B. R.</creatorcontrib><creatorcontrib>Geldof, A. A.</creatorcontrib><creatorcontrib>Gooren, L. J. G.</creatorcontrib><creatorcontrib>Bouman, F. G.</creatorcontrib><title>Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl estradiol, prostate volumes again were not changed. However, histology revealed glandular atrophy and an increase in stromal tissue. The significance of these findings is discussed.</description><subject>Adult</subject><subject>Androgen Antagonists - pharmacology</subject><subject>anti-androgens</subject><subject>Biological and medical sciences</subject><subject>Cyproterone - analogs & derivatives</subject><subject>Cyproterone - pharmacology</subject><subject>Cyproterone Acetate</subject><subject>Ethinyl Estradiol - pharmacology</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazolidines</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>normal human prostate</subject><subject>Prolactin - blood</subject><subject>Prostate - anatomy & histology</subject><subject>Prostate - cytology</subject><subject>Prostate - drug effects</subject><subject>Testosterone - blood</subject><subject>Vertebrates: reproduction</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtv1DAQxi0EKkvhzAnJB8Qt7TiO41ic2qoPyooiHurRcvzYDXXixU4Ey19fr7JaxInTzGh-38ynD6HXBE4IQHm6iSGdlEIAIVABfYIWBAQvACr2FC2g5FBUhPLn6EVKPwCyBsojdFSKGgQTC7Q5G0wMKztgpccuDLj1QT8oY7EJNuEhjDjaNPkRd0PuzDRTeUjdH4vbacR6rYZVZtddGoMPqy0ODo9rm8WxVx6vp14NeGd0VKN9iZ455ZN9ta_H6PvV5beLm2J5d_3h4mxZ6IoQWjCltasFg5LWRjhu2spSpwXTNSXKuYYBM8w6BdTQRikwrmyJsa5qG9OAo8fo3Xw3P_452TTKvkvaeq8GG6YkOW-qsiYsg6czqLPDFK2Tm9j1Km4lAbnLWO6sy78ZZ8Wb_emp7a058PtQ8_7tfq-SVt5FNeguHTDeUMLFDns_Y786b7f_-yo_f7n7-o-JYlbn1O3vg1rFB1lzypm8_3QtP56f3942_F4u6SPCe6gU</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>De Voogt, H. J.</creator><creator>Rao, B. R.</creator><creator>Geldof, A. A.</creator><creator>Gooren, L. J. G.</creator><creator>Bouman, F. G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate</title><author>De Voogt, H. J. ; Rao, B. R. ; Geldof, A. A. ; Gooren, L. J. G. ; Bouman, F. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4113-5accf6950236d9f7db4e3fc95c631aff8505d5efa03d38aa0df2b1def4b8d80f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Androgen Antagonists - pharmacology</topic><topic>anti-androgens</topic><topic>Biological and medical sciences</topic><topic>Cyproterone - analogs & derivatives</topic><topic>Cyproterone - pharmacology</topic><topic>Cyproterone Acetate</topic><topic>Ethinyl Estradiol - pharmacology</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazolidines</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>normal human prostate</topic><topic>Prolactin - blood</topic><topic>Prostate - anatomy & histology</topic><topic>Prostate - cytology</topic><topic>Prostate - drug effects</topic><topic>Testosterone - blood</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Voogt, H. J.</creatorcontrib><creatorcontrib>Rao, B. R.</creatorcontrib><creatorcontrib>Geldof, A. A.</creatorcontrib><creatorcontrib>Gooren, L. J. G.</creatorcontrib><creatorcontrib>Bouman, F. 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G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>1987</date><risdate>1987</risdate><volume>11</volume><issue>4</issue><spage>305</spage><epage>311</epage><pages>305-311</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl estradiol, prostate volumes again were not changed. However, histology revealed glandular atrophy and an increase in stromal tissue. The significance of these findings is discussed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2960959</pmid><doi>10.1002/pros.2990110403</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Prostate, 1987, Vol.11 (4), p.305-311 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Androgen Antagonists - pharmacology anti-androgens Biological and medical sciences Cyproterone - analogs & derivatives Cyproterone - pharmacology Cyproterone Acetate Ethinyl Estradiol - pharmacology Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Imidazoles - pharmacology Imidazolidines Luteinizing Hormone - blood Male Mammalian male genital system normal human prostate Prolactin - blood Prostate - anatomy & histology Prostate - cytology Prostate - drug effects Testosterone - blood Vertebrates: reproduction |
| title | Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate |
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