Cocaine inhibits extraneuronal O-methylation of exogenous norepinephrine in nasal and oral tissues of the rabbit

Nasal mucosa (respiratory and olfactory) and lingual gingiva of the rabbit were depleted of their sympathetic nerves by superior cervical ganglionectomy. In the innervated nasal mucosa, exogenous tritiated norepinephrine ( 3H-NE) was metabolised mainly to tritiated 3,4-dihydroxyphenylethylene glycol...

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Veröffentlicht in:	Life Sci.; (United States) 1987-11, Vol.41 (22), p.2463-2468
Hauptverfasser:	de la Lande, Ivan S., Parker, David A.S., Proctor, Craig H., Marino, Victor, Mackay-Sim, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ADRENAL HORMONES ALKALOIDS ANESTHETICS ANIMALS ANTIDEPRESSANTS AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BODY BODY AREAS CARDIOTONICS CARDIOVASCULAR AGENTS CENTRAL NERVOUS SYSTEM AGENTS CENTRAL NERVOUS SYSTEM DEPRESSANTS CHEMICAL REACTIONS COCAINE Cocaine - pharmacology DIGESTIVE SYSTEM Drug addictions DRUGS FACE Ganglia, Spinal - physiology Gingiva - drug effects Gingiva - metabolism HEAD In Vitro Techniques INHIBITION ISOTOPE APPLICATIONS LABELLED COMPOUNDS MAMMALS Medical sciences MEMBRANES METABOLISM METHYLATION MUCOUS MEMBRANES Nasal Mucosa - drug effects Nasal Mucosa - innervation Nasal Mucosa - metabolism NEUROREGULATORS NORADRENALINE Norepinephrine - metabolism NOSE ORAL CAVITY ORGANIC COMPOUNDS PSYCHOTROPIC DRUGS RABBITS RESPIRATORY SYSTEM SYMPATHOMIMETICS Toxicology TRACER TECHNIQUES TRITIUM COMPOUNDS VERTEBRATES
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