13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets
The effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE), a major lipoxygenase product of endothelial cell linoleic acid metabolism on thrombin-induced platelet thromboxane B2 (TxB2), and 12-hydroxyeico-satetraenoic acid (12-HETE) production was evaluated. 13-HODE inhibited thrombin-induced TxB2...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1987-10, Vol.148 (2), p.528-533 |
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| creator | YAMAJA SETTY, B. N BERGER, M STUART, M. J |
| description | The effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE), a major lipoxygenase product of endothelial cell linoleic acid metabolism on thrombin-induced platelet thromboxane B2 (TxB2), and 12-hydroxyeico-satetraenoic acid (12-HETE) production was evaluated. 13-HODE inhibited thrombin-induced TxB2 production in human platelets in a concentration-dependent manner. At concentrations of 10 and 30 microM, 13-HODE inhibited TxB2 production by 28 +/- 8% (1SE, n = 5; P less than 0.05) and 48 +/- 6% (P less than 0.01) respectively. 13-HODE (30 microM) also inhibited the production of platelet hydroxyheptadecatrienoic acid (38 +/- 5%, P less than 0.01). A concomitant stimulation of 12-HETE production by 13-HODE was observed (25 +/- 5% and 49 +/- 22% over control values at 10 and 30 microM respectively, P less than 0.01). Our results demonstrate a differential effect of 13-HODE on thrombin stimulated platelet cyclooxygenase and lipoxygenase metabolites. |
| doi_str_mv | 10.1016/0006-291X(87)90908-9 |
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N ; BERGER, M ; STUART, M. J</creator><creatorcontrib>YAMAJA SETTY, B. N ; BERGER, M ; STUART, M. J</creatorcontrib><description>The effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE), a major lipoxygenase product of endothelial cell linoleic acid metabolism on thrombin-induced platelet thromboxane B2 (TxB2), and 12-hydroxyeico-satetraenoic acid (12-HETE) production was evaluated. 13-HODE inhibited thrombin-induced TxB2 production in human platelets in a concentration-dependent manner. At concentrations of 10 and 30 microM, 13-HODE inhibited TxB2 production by 28 +/- 8% (1SE, n = 5; P less than 0.05) and 48 +/- 6% (P less than 0.01) respectively. 13-HODE (30 microM) also inhibited the production of platelet hydroxyheptadecatrienoic acid (38 +/- 5%, P less than 0.01). A concomitant stimulation of 12-HETE production by 13-HODE was observed (25 +/- 5% and 49 +/- 22% over control values at 10 and 30 microM respectively, P less than 0.01). Our results demonstrate a differential effect of 13-HODE on thrombin stimulated platelet cyclooxygenase and lipoxygenase metabolites.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(87)90908-9</identifier><identifier>PMID: 3120708</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid ; Adult ; Antithrombins - pharmacology ; Applied sciences ; Arachidonic Acid ; Arachidonic Acids - blood ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Exact sciences and technology ; Humans ; Hydroxyeicosatetraenoic Acids - biosynthesis ; Hydroxyeicosatetraenoic Acids - blood ; Kinetics ; Linoleic Acids - pharmacology ; Other techniques and industries ; Phospholipids - biosynthesis ; Phospholipids - blood ; Platelet Aggregation ; Thromboxane B2 - biosynthesis ; Thromboxane B2 - blood</subject><ispartof>Biochemical and biophysical research communications, 1987-10, Vol.148 (2), p.528-533</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-532006722bdd0ceea8331bd06f470550ef0ec8d161b3b07817c7e1d3859764093</citedby><cites>FETCH-LOGICAL-c331t-532006722bdd0ceea8331bd06f470550ef0ec8d161b3b07817c7e1d3859764093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7847752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3120708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMAJA SETTY, B. N</creatorcontrib><creatorcontrib>BERGER, M</creatorcontrib><creatorcontrib>STUART, M. J</creatorcontrib><title>13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE), a major lipoxygenase product of endothelial cell linoleic acid metabolism on thrombin-induced platelet thromboxane B2 (TxB2), and 12-hydroxyeico-satetraenoic acid (12-HETE) production was evaluated. 13-HODE inhibited thrombin-induced TxB2 production in human platelets in a concentration-dependent manner. At concentrations of 10 and 30 microM, 13-HODE inhibited TxB2 production by 28 +/- 8% (1SE, n = 5; P less than 0.05) and 48 +/- 6% (P less than 0.01) respectively. 13-HODE (30 microM) also inhibited the production of platelet hydroxyheptadecatrienoic acid (38 +/- 5%, P less than 0.01). A concomitant stimulation of 12-HETE production by 13-HODE was observed (25 +/- 5% and 49 +/- 22% over control values at 10 and 30 microM respectively, P less than 0.01). Our results demonstrate a differential effect of 13-HODE on thrombin stimulated platelet cyclooxygenase and lipoxygenase metabolites.</description><subject>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid</subject><subject>Adult</subject><subject>Antithrombins - pharmacology</subject><subject>Applied sciences</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - blood</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids - biosynthesis</subject><subject>Hydroxyeicosatetraenoic Acids - blood</subject><subject>Kinetics</subject><subject>Linoleic Acids - pharmacology</subject><subject>Other techniques and industries</subject><subject>Phospholipids - biosynthesis</subject><subject>Phospholipids - blood</subject><subject>Platelet Aggregation</subject><subject>Thromboxane B2 - biosynthesis</subject><subject>Thromboxane B2 - blood</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFu1DAQhi0EKkvhDUDyAaFWqmHGTmLnWJWFRarUS5G4WY7taI2SeIkdqfsCPDcOXe3JlufzPzMfIe8RPiNg8wUAGsZb_HWl5HULLSjWviAbLDfGEaqXZHNGXpM3Kf0GQKya9oJcCOQgQW3IXxRsd3RzfDpGm43z1rD2BpG54KcYLDU2OHq1Ug9ft9c0TPvQhZxo3s9x7OKTmTy95TQdp7z3KaQbaiZHUw7jMpjsE0XOdtvHLT3M0S02hziVELpfRjPRw4oMPqe35FVvhuTfnc5L8vPb9vFux-4fvv-4u71nVgjMrBa8bCQ575wD671R5blz0PSVhLoG34O3ymGDnehAKpRWenRC1a1sKmjFJfn0nFum-bP4lPUYkvXDUNaIS9JSqgor2RSwegbtHFOafa8PcxjNfNQIetWvV7d6dauV1P_16zX_wyl_6Ubvzp9Ovkv946lukjVDP5vJhnTGSncpay7-ASspi0k</recordid><startdate>19871029</startdate><enddate>19871029</enddate><creator>YAMAJA SETTY, B. N</creator><creator>BERGER, M</creator><creator>STUART, M. J</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871029</creationdate><title>13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets</title><author>YAMAJA SETTY, B. N ; BERGER, M ; STUART, M. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-532006722bdd0ceea8331bd06f470550ef0ec8d161b3b07817c7e1d3859764093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid</topic><topic>Adult</topic><topic>Antithrombins - pharmacology</topic><topic>Applied sciences</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - blood</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids - biosynthesis</topic><topic>Hydroxyeicosatetraenoic Acids - blood</topic><topic>Kinetics</topic><topic>Linoleic Acids - pharmacology</topic><topic>Other techniques and industries</topic><topic>Phospholipids - biosynthesis</topic><topic>Phospholipids - blood</topic><topic>Platelet Aggregation</topic><topic>Thromboxane B2 - biosynthesis</topic><topic>Thromboxane B2 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAMAJA SETTY, B. N</creatorcontrib><creatorcontrib>BERGER, M</creatorcontrib><creatorcontrib>STUART, M. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMAJA SETTY, B. N</au><au>BERGER, M</au><au>STUART, M. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1987-10-29</date><risdate>1987</risdate><volume>148</volume><issue>2</issue><spage>528</spage><epage>533</epage><pages>528-533</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE), a major lipoxygenase product of endothelial cell linoleic acid metabolism on thrombin-induced platelet thromboxane B2 (TxB2), and 12-hydroxyeico-satetraenoic acid (12-HETE) production was evaluated. 13-HODE inhibited thrombin-induced TxB2 production in human platelets in a concentration-dependent manner. At concentrations of 10 and 30 microM, 13-HODE inhibited TxB2 production by 28 +/- 8% (1SE, n = 5; P less than 0.05) and 48 +/- 6% (P less than 0.01) respectively. 13-HODE (30 microM) also inhibited the production of platelet hydroxyheptadecatrienoic acid (38 +/- 5%, P less than 0.01). A concomitant stimulation of 12-HETE production by 13-HODE was observed (25 +/- 5% and 49 +/- 22% over control values at 10 and 30 microM respectively, P less than 0.01). Our results demonstrate a differential effect of 13-HODE on thrombin stimulated platelet cyclooxygenase and lipoxygenase metabolites.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>3120708</pmid><doi>10.1016/0006-291X(87)90908-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1987-10, Vol.148 (2), p.528-533 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Adult Antithrombins - pharmacology Applied sciences Arachidonic Acid Arachidonic Acids - blood Blood Platelets - drug effects Blood Platelets - metabolism Exact sciences and technology Humans Hydroxyeicosatetraenoic Acids - biosynthesis Hydroxyeicosatetraenoic Acids - blood Kinetics Linoleic Acids - pharmacology Other techniques and industries Phospholipids - biosynthesis Phospholipids - blood Platelet Aggregation Thromboxane B2 - biosynthesis Thromboxane B2 - blood |
| title | 13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets |
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