Immunity to Schistosomes: Progress toward Vaccine
Among the major parasitic infections, schistosomiasis may be the most promising candidate for human vaccination. Information about mechanisms of immunity, gained mainly from experimental models but likely to be relevant to human infection, indicates a dynamic balance between protective and regulator...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1987-11, Vol.238 (4830), p.1065-1072 |
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| creator | Capron, André Dessaint, J. P. Capron, M. Ouma, J. H. Butterworth, A. E. |
| description | Among the major parasitic infections, schistosomiasis may be the most promising candidate for human vaccination. Information about mechanisms of immunity, gained mainly from experimental models but likely to be relevant to human infection, indicates a dynamic balance between protective and regulatory (blocking) mechanisms. Besides cell-mediated responses leading to macrophage activation, antibody-dependent cell-mediated cytotoxicity systems involving precise antibody isotypes and nonlymphoid cells (mononuclear phagocytes, eosinophils, and platelets) appear to be essential effectors of immune attack. The slow development of immunity in humans seems related to the production of antibodies that cross-react with schistosomulum surface antigen and block the binding of antibodies of the effector isotype. Schistosomes that survive in the bloodstream and produce chronic infections may evade the immune system as a result of intrinsic changes in membrane susceptibility and of transient expression of target antigens; at other stages of the parasite life cycle, cross-reactive molecules may be secreted that play an essential role in the induction of immunity. Several schistosome proteins have been characterized as candidates for vaccination. Among these, an antigen of 28 kilodaltons has been cloned and shown to be immunogenic in humans and protective in mice, rats, and baboons. |
| doi_str_mv | 10.1126/science.3317823 |
| format | Article |
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P. ; Capron, M. ; Ouma, J. H. ; Butterworth, A. E.</creator><creatorcontrib>Capron, André ; Dessaint, J. P. ; Capron, M. ; Ouma, J. H. ; Butterworth, A. E.</creatorcontrib><description>Among the major parasitic infections, schistosomiasis may be the most promising candidate for human vaccination. Information about mechanisms of immunity, gained mainly from experimental models but likely to be relevant to human infection, indicates a dynamic balance between protective and regulatory (blocking) mechanisms. Besides cell-mediated responses leading to macrophage activation, antibody-dependent cell-mediated cytotoxicity systems involving precise antibody isotypes and nonlymphoid cells (mononuclear phagocytes, eosinophils, and platelets) appear to be essential effectors of immune attack. The slow development of immunity in humans seems related to the production of antibodies that cross-react with schistosomulum surface antigen and block the binding of antibodies of the effector isotype. Schistosomes that survive in the bloodstream and produce chronic infections may evade the immune system as a result of intrinsic changes in membrane susceptibility and of transient expression of target antigens; at other stages of the parasite life cycle, cross-reactive molecules may be secreted that play an essential role in the induction of immunity. Several schistosome proteins have been characterized as candidates for vaccination. Among these, an antigen of 28 kilodaltons has been cloned and shown to be immunogenic in humans and protective in mice, rats, and baboons.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3317823</identifier><identifier>PMID: 3317823</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animals ; Antibodies ; Antibodies, Helminth - immunology ; Antibody-Dependent Cell Cytotoxicity ; Antigens ; Antigens, Helminth - immunology ; Biological and medical sciences ; Cytotoxicity, Immunologic ; Disease ; Eosinophils ; Fundamental and applied biological sciences. Psychology ; Humans ; Immune response ; Immunity ; Immunity, Cellular ; Infections ; Life cycle. Host-agent relationship. Pathogenesis ; Medical research ; Parasites ; Parasitic diseases ; Physiological aspects ; Platelets ; Protozoa ; Rats ; Schistosoma ; Schistosoma - immunology ; Schistosoma mansoni ; Schistosomiasis ; Schistosomiasis - immunology ; Schistosomula ; T lymphocytes ; Vaccines ; Vaccines - immunology</subject><ispartof>Science (American Association for the Advancement of Science), 1987-11, Vol.238 (4830), p.1065-1072</ispartof><rights>Copyright 1987 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 20, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-52c803820c0705292539c290db171e9ead3900e15a1ea09ea87a42a03aa2d2203</citedby><cites>FETCH-LOGICAL-c730t-52c803820c0705292539c290db171e9ead3900e15a1ea09ea87a42a03aa2d2203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1700843$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1700843$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7564937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3317823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capron, André</creatorcontrib><creatorcontrib>Dessaint, J. P.</creatorcontrib><creatorcontrib>Capron, M.</creatorcontrib><creatorcontrib>Ouma, J. H.</creatorcontrib><creatorcontrib>Butterworth, A. E.</creatorcontrib><title>Immunity to Schistosomes: Progress toward Vaccine</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Among the major parasitic infections, schistosomiasis may be the most promising candidate for human vaccination. Information about mechanisms of immunity, gained mainly from experimental models but likely to be relevant to human infection, indicates a dynamic balance between protective and regulatory (blocking) mechanisms. Besides cell-mediated responses leading to macrophage activation, antibody-dependent cell-mediated cytotoxicity systems involving precise antibody isotypes and nonlymphoid cells (mononuclear phagocytes, eosinophils, and platelets) appear to be essential effectors of immune attack. The slow development of immunity in humans seems related to the production of antibodies that cross-react with schistosomulum surface antigen and block the binding of antibodies of the effector isotype. Schistosomes that survive in the bloodstream and produce chronic infections may evade the immune system as a result of intrinsic changes in membrane susceptibility and of transient expression of target antigens; at other stages of the parasite life cycle, cross-reactive molecules may be secreted that play an essential role in the induction of immunity. Several schistosome proteins have been characterized as candidates for vaccination. Among these, an antigen of 28 kilodaltons has been cloned and shown to be immunogenic in humans and protective in mice, rats, and baboons.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Helminth - immunology</subject><subject>Antibody-Dependent Cell Cytotoxicity</subject><subject>Antigens</subject><subject>Antigens, Helminth - immunology</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity, Immunologic</subject><subject>Disease</subject><subject>Eosinophils</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunity</subject><subject>Immunity, Cellular</subject><subject>Infections</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Medical research</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Physiological aspects</subject><subject>Platelets</subject><subject>Protozoa</subject><subject>Rats</subject><subject>Schistosoma</subject><subject>Schistosoma - immunology</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis - immunology</subject><subject>Schistosomula</subject><subject>T lymphocytes</subject><subject>Vaccines</subject><subject>Vaccines - immunology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN00Fv0zAUAGALgUYZnLmAVE0IDiPbsx3HMbdRQalUUaTBrpbnvIRUSTzsRLB_j6tG20CVWvlg2e-zn2U_E_KSwhmlLDsPtsbO4hnnVOaMPyITCkokigF_TCYAPEtykOIpeRbCGiDGFD8iRyOfELpo26Gr-9tp76aX9mcdehdci-HD9Jt3lccQYuS38cX0ylhbd_icPClNE_DF2B-TH58_fZ99SZar-WJ2sUys5NAngtkceM7AggTBFBNcWaaguKaSokJTcAWAVBiKBuI4lyZlBrgxrGDx-Mfk7XbfG-9-DRh63dbBYtOYDt0QtJQ5zxWjeyEXTKQqF3sho1RyQdO9kArgSqWb1Cf_wbUbfBevJW7GBWcpZBGdblFlGtR1V7reG1thh940rsOyjtMXGY3HBBn1-x06tgLb2u7g7_7hUfT4p6_MEIJeXH49VK6uDpUf5wfKfL58KE93SeuaBivUsXJmq4f6fKutdyF4LPWNr1vjbzUFval7Pda9Hgs5rng9vsRw3WJx5-_jb8a4CdY0pTedrcMdkyJLFd8kfrVl6_gP_H1WCZCnnP8FHIINkQ</recordid><startdate>19871120</startdate><enddate>19871120</enddate><creator>Capron, André</creator><creator>Dessaint, J. 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Pathogenesis</topic><topic>Medical research</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Physiological aspects</topic><topic>Platelets</topic><topic>Protozoa</topic><topic>Rats</topic><topic>Schistosoma</topic><topic>Schistosoma - immunology</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis - immunology</topic><topic>Schistosomula</topic><topic>T lymphocytes</topic><topic>Vaccines</topic><topic>Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capron, André</creatorcontrib><creatorcontrib>Dessaint, J. P.</creatorcontrib><creatorcontrib>Capron, M.</creatorcontrib><creatorcontrib>Ouma, J. H.</creatorcontrib><creatorcontrib>Butterworth, A. 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P.</au><au>Capron, M.</au><au>Ouma, J. H.</au><au>Butterworth, A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunity to Schistosomes: Progress toward Vaccine</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1987-11-20</date><risdate>1987</risdate><volume>238</volume><issue>4830</issue><spage>1065</spage><epage>1072</epage><pages>1065-1072</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Among the major parasitic infections, schistosomiasis may be the most promising candidate for human vaccination. Information about mechanisms of immunity, gained mainly from experimental models but likely to be relevant to human infection, indicates a dynamic balance between protective and regulatory (blocking) mechanisms. Besides cell-mediated responses leading to macrophage activation, antibody-dependent cell-mediated cytotoxicity systems involving precise antibody isotypes and nonlymphoid cells (mononuclear phagocytes, eosinophils, and platelets) appear to be essential effectors of immune attack. The slow development of immunity in humans seems related to the production of antibodies that cross-react with schistosomulum surface antigen and block the binding of antibodies of the effector isotype. Schistosomes that survive in the bloodstream and produce chronic infections may evade the immune system as a result of intrinsic changes in membrane susceptibility and of transient expression of target antigens; at other stages of the parasite life cycle, cross-reactive molecules may be secreted that play an essential role in the induction of immunity. Several schistosome proteins have been characterized as candidates for vaccination. Among these, an antigen of 28 kilodaltons has been cloned and shown to be immunogenic in humans and protective in mice, rats, and baboons.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3317823</pmid><doi>10.1126/science.3317823</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1987-11, Vol.238 (4830), p.1065-1072 |
| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; Science Magazine; Jstor Complete Legacy |
| subjects | Animals Antibodies Antibodies, Helminth - immunology Antibody-Dependent Cell Cytotoxicity Antigens Antigens, Helminth - immunology Biological and medical sciences Cytotoxicity, Immunologic Disease Eosinophils Fundamental and applied biological sciences. Psychology Humans Immune response Immunity Immunity, Cellular Infections Life cycle. Host-agent relationship. Pathogenesis Medical research Parasites Parasitic diseases Physiological aspects Platelets Protozoa Rats Schistosoma Schistosoma - immunology Schistosoma mansoni Schistosomiasis Schistosomiasis - immunology Schistosomula T lymphocytes Vaccines Vaccines - immunology |
| title | Immunity to Schistosomes: Progress toward Vaccine |
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