An in-vitro evaluation of coralline porous hydroxyapatite as a scaffold for osteoblast growth
The purpose of this study was to determine the potential of coralline calcium phosphate ceramics to support osteoblast growth for a proposed boneceramic cerposite for skeletal tissue repair. The goal was the development of a matrix with both osteogenic and osteoconductive properties, as compared to...
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| Veröffentlicht in: | Clinical materials 1994, Vol.17 (2), p.85-91 |
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| container_title | Clinical materials |
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| creator | Norman, Maria E. Elgendy, Hoda M. Shors, Edwin C. El-Amin, Saadiq F. Laurencin, Cato T. |
| description | The purpose of this study was to determine the potential of coralline calcium phosphate ceramics to support osteoblast growth for a proposed boneceramic cerposite for skeletal tissue repair. The goal was the development of a matrix with both osteogenic and osteoconductive properties, as compared to ceramic alone, which is solely osteoconductive. MC3T3-E1 osteoblast-like cells were seeded onto sintered and non-sintered porous coralline hydroxyapatite (HA), and onto non-porous hydroxyapatite discs. These in-vitro studies demonstrated that coralline HA supported the growth of osteoblast-like cells. Porous discs supported higher numbers of cells than non-porous discs. Sintering encouraged cell growth, with higher numbers of cells adhered to sintered porous HA discs by day seven. The results suggest that HA can provide a support for osteoblast cells as part of a matrix which may prove to be osteogenic
in vivo and may, accordingly, enhance the bone repair process. |
| doi_str_mv | 10.1016/0267-6605(94)90016-7 |
| format | Article |
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in vivo and may, accordingly, enhance the bone repair process.</description><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Ceramics</subject><subject>Durapatite</subject><subject>Health technology assessment</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osseointegration - physiology</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - physiology</subject><subject>Porosity</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Technology. Biomaterials. Equipments. Material. 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Instrumentation</topic><toplevel>online_resources</toplevel><creatorcontrib>Norman, Maria E.</creatorcontrib><creatorcontrib>Elgendy, Hoda M.</creatorcontrib><creatorcontrib>Shors, Edwin C.</creatorcontrib><creatorcontrib>El-Amin, Saadiq F.</creatorcontrib><creatorcontrib>Laurencin, Cato T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, Maria E.</au><au>Elgendy, Hoda M.</au><au>Shors, Edwin C.</au><au>El-Amin, Saadiq F.</au><au>Laurencin, Cato T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An in-vitro evaluation of coralline porous hydroxyapatite as a scaffold for osteoblast growth</atitle><jtitle>Clinical materials</jtitle><addtitle>Clin Mater</addtitle><date>1994</date><risdate>1994</risdate><volume>17</volume><issue>2</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0267-6605</issn><eissn>1878-6979</eissn><abstract>The purpose of this study was to determine the potential of coralline calcium phosphate ceramics to support osteoblast growth for a proposed boneceramic cerposite for skeletal tissue repair. The goal was the development of a matrix with both osteogenic and osteoconductive properties, as compared to ceramic alone, which is solely osteoconductive. MC3T3-E1 osteoblast-like cells were seeded onto sintered and non-sintered porous coralline hydroxyapatite (HA), and onto non-porous hydroxyapatite discs. These in-vitro studies demonstrated that coralline HA supported the growth of osteoblast-like cells. Porous discs supported higher numbers of cells than non-porous discs. Sintering encouraged cell growth, with higher numbers of cells adhered to sintered porous HA discs by day seven. The results suggest that HA can provide a support for osteoblast cells as part of a matrix which may prove to be osteogenic
in vivo and may, accordingly, enhance the bone repair process.</abstract><cop>London</cop><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>10150211</pmid><doi>10.1016/0267-6605(94)90016-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0267-6605 |
| ispartof | Clinical materials, 1994, Vol.17 (2), p.85-91 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biocompatible Materials Biological and medical sciences Cell Division Cell Line Ceramics Durapatite Health technology assessment Humans In Vitro Techniques Medical sciences Microscopy, Electron, Scanning Osseointegration - physiology Osteoblasts - cytology Osteoblasts - physiology Porosity Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | An in-vitro evaluation of coralline porous hydroxyapatite as a scaffold for osteoblast growth |
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