T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease
T-cell receptor α- and ß-chain polymorphisms have been investigated in patients with autoimmune thyroid disease. Using a cDNA probe for the T-cell receptor α chain, a 1.4-kb V α Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subj...
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| Veröffentlicht in: | Human immunology 1987-10, Vol.20 (2), p.167-173 |
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| container_title | Human immunology |
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| creator | Weetman, A.P. So, A.K. Roe, C. Walport, M.J. Foroni, L. |
| description | T-cell receptor α- and ß-chain polymorphisms have been investigated in patients with autoimmune thyroid disease. Using a cDNA probe for the T-cell receptor α chain, a 1.4-kb V
α Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subjects (
p < 0.05) and 16 of 43 patients with Graves' disease (
p < 0.001 compared to patients with autoimmune hypothyroidism). Moreover, when Graves' patients were divided according to HLA-DR3 status, there was a significantly reduced frequency of the 1.4-kb V
α fragment in HLA-DR3-negative patients (
p < 0.05 compared to controls). There was no significant association of either thyroid disorder with polymorphisms of the T-cell receptor α- or ß-chain-constant region genes, after Taq I and Bgl II digestion, respectively. These results show that inherited variation in T-cell receptor genes, recognizable before any somatic event has taken place, may play a role in susceptibility to autoimmune disease. |
| doi_str_mv | 10.1016/0198-8859(87)90030-9 |
| format | Article |
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α Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subjects (
p < 0.05) and 16 of 43 patients with Graves' disease (
p < 0.001 compared to patients with autoimmune hypothyroidism). Moreover, when Graves' patients were divided according to HLA-DR3 status, there was a significantly reduced frequency of the 1.4-kb V
α fragment in HLA-DR3-negative patients (
p < 0.05 compared to controls). There was no significant association of either thyroid disorder with polymorphisms of the T-cell receptor α- or ß-chain-constant region genes, after Taq I and Bgl II digestion, respectively. These results show that inherited variation in T-cell receptor genes, recognizable before any somatic event has taken place, may play a role in susceptibility to autoimmune disease.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/0198-8859(87)90030-9</identifier><identifier>PMID: 2890606</identifier><identifier>CODEN: HUIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Autoimmune Diseases - genetics ; Biological and medical sciences ; Endocrinopathies ; Graves Disease - genetics ; Humans ; Hypothyroidism - genetics ; Malignant tumors ; Medical sciences ; Polymorphism, Restriction Fragment Length ; Receptors, Antigen, T-Cell - genetics ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Human immunology, 1987-10, Vol.20 (2), p.167-173</ispartof><rights>1987</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7550bc08f11c89e5a62e840a9626302f9b82acb58525c168d81714a5f64a68a73</citedby><cites>FETCH-LOGICAL-c417t-7550bc08f11c89e5a62e840a9626302f9b82acb58525c168d81714a5f64a68a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0198-8859(87)90030-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7331245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2890606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weetman, A.P.</creatorcontrib><creatorcontrib>So, A.K.</creatorcontrib><creatorcontrib>Roe, C.</creatorcontrib><creatorcontrib>Walport, M.J.</creatorcontrib><creatorcontrib>Foroni, L.</creatorcontrib><title>T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>T-cell receptor α- and ß-chain polymorphisms have been investigated in patients with autoimmune thyroid disease. Using a cDNA probe for the T-cell receptor α chain, a 1.4-kb V
α Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subjects (
p < 0.05) and 16 of 43 patients with Graves' disease (
p < 0.001 compared to patients with autoimmune hypothyroidism). Moreover, when Graves' patients were divided according to HLA-DR3 status, there was a significantly reduced frequency of the 1.4-kb V
α fragment in HLA-DR3-negative patients (
p < 0.05 compared to controls). There was no significant association of either thyroid disorder with polymorphisms of the T-cell receptor α- or ß-chain-constant region genes, after Taq I and Bgl II digestion, respectively. These results show that inherited variation in T-cell receptor genes, recognizable before any somatic event has taken place, may play a role in susceptibility to autoimmune disease.</description><subject>Autoimmune Diseases - genetics</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Graves Disease - genetics</subject><subject>Humans</subject><subject>Hypothyroidism - genetics</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2O1DAQhS0EGnoGbgCSF4ifRaCcOP7ZIKEZGJBGYjOwtRynQhuSONjOSH0sLsKZSOiol7Aqqep7par3CHnC4DUDJt4A06pQqtYvlXylASoo9D2yY0rqgjEh7pPdCXlIzlP6DgASJD8jZ6XSIEDsSLwtHPY9jehwyiHS37-o21s_0q9L75sPI51CfxhCnPY-DbT34w9saQ50in6w8UDtnIMfhnlEuj9MIe8PMfh2ZZs50zFkeh3tHaYX9MontAkfkQed7RM-3uoF-fLh_e3lx-Lm8_Wny3c3heNM5kLWNTQOVMeYUxprK0pUHKwWpaig7HSjSuuaWtVl7ZhQrWKScVt3gluhrKwuyPPj3imGnzOmbAaf1mftiGFORkpVcS7gvyDjSjFelQvIj6CLIaWIndlMMAzMmolZDTer4UZJ8zcToxfZ023_3AzYnkRbCMv82Ta3ydm-i3Z0Pp0wWVWs5PWCvT1iuJh25zGa5DyODlu_pJdNG_y_7_gDLyOo_g</recordid><startdate>19871001</startdate><enddate>19871001</enddate><creator>Weetman, A.P.</creator><creator>So, A.K.</creator><creator>Roe, C.</creator><creator>Walport, M.J.</creator><creator>Foroni, L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19871001</creationdate><title>T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease</title><author>Weetman, A.P. ; So, A.K. ; Roe, C. ; Walport, M.J. ; Foroni, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7550bc08f11c89e5a62e840a9626302f9b82acb58525c168d81714a5f64a68a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Autoimmune Diseases - genetics</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Graves Disease - genetics</topic><topic>Humans</topic><topic>Hypothyroidism - genetics</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weetman, A.P.</creatorcontrib><creatorcontrib>So, A.K.</creatorcontrib><creatorcontrib>Roe, C.</creatorcontrib><creatorcontrib>Walport, M.J.</creatorcontrib><creatorcontrib>Foroni, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weetman, A.P.</au><au>So, A.K.</au><au>Roe, C.</au><au>Walport, M.J.</au><au>Foroni, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1987-10-01</date><risdate>1987</risdate><volume>20</volume><issue>2</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><coden>HUIMDQ</coden><abstract>T-cell receptor α- and ß-chain polymorphisms have been investigated in patients with autoimmune thyroid disease. Using a cDNA probe for the T-cell receptor α chain, a 1.4-kb V
α Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subjects (
p < 0.05) and 16 of 43 patients with Graves' disease (
p < 0.001 compared to patients with autoimmune hypothyroidism). Moreover, when Graves' patients were divided according to HLA-DR3 status, there was a significantly reduced frequency of the 1.4-kb V
α fragment in HLA-DR3-negative patients (
p < 0.05 compared to controls). There was no significant association of either thyroid disorder with polymorphisms of the T-cell receptor α- or ß-chain-constant region genes, after Taq I and Bgl II digestion, respectively. These results show that inherited variation in T-cell receptor genes, recognizable before any somatic event has taken place, may play a role in susceptibility to autoimmune disease.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2890606</pmid><doi>10.1016/0198-8859(87)90030-9</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human immunology, 1987-10, Vol.20 (2), p.167-173 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Autoimmune Diseases - genetics Biological and medical sciences Endocrinopathies Graves Disease - genetics Humans Hypothyroidism - genetics Malignant tumors Medical sciences Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell - genetics Thyroid. Thyroid axis (diseases) |
| title | T-cell receptor α chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' Disease |
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