Biochemical and behavioral effects of intrahippocampal AF64A in rats

AF64A (ethylcholine aziridinium, 1 nmole) injected into the dorsal hippocampus of the rat decreased choline acetyltransferase activity there by 20% without greatly affecting adjacent areas. The decrease was maximal by 3 days, and persisted for at least 3 weeks. The acetylcholine concentration at the...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1987-10, Vol.28 (2), p.157-163
Hauptverfasser:	Blaker, William D., Goodwin, Susan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - analysis Acetylcholine Choline acetyltransferase AF64A Animals Aziridines - pharmacology Azirines - pharmacology Biochemistry and metabolism Biological and medical sciences Central nervous system Choline - analogs & derivatives Choline - pharmacology Choline O-Acetyltransferase - metabolism Ethylcholine aziridinium Extinction Extinction, Psychological - drug effects Fundamental and applied biological sciences. Psychology Habituation, Psychophysiologic - drug effects Hippocampus Hippocampus - analysis Hippocampus - drug effects Hippocampus - enzymology Learning - drug effects Male Memory - drug effects Radial arm maze Rats Rats, Inbred Strains Spatial Behavior - drug effects Superior Colliculi - drug effects Vertebrates: nervous system and sense organs
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