Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro

Intracranial malignant gliomas are sequestered from the immune system yet are associated with broad suppression of host immunocompetence. Immune system dysfunction in patients with gliomas seems to be related to inhibitory mediators produced by glioma cells. We investigated the physiological roles o...

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Veröffentlicht in:	Neurosurgery 1995-12, Vol.37 (6), p.1160-1167
Hauptverfasser:	Hishii, M, Nitta, T, Ishida, H, Ebato, M, Kurosu, A, Yagita, H, Sato, K, Okumura, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - immunology Cell Line Cytokines - antagonists & inhibitors Cytokines - physiology Down-Regulation - physiology Glioblastoma - immunology Glioma - immunology Histocompatibility Antigens Class II - physiology Humans Immune Tolerance - immunology Interleukin-10 - physiology Lymphocyte Activation - immunology T-Lymphocytes - immunology Tumor Cells, Cultured - immunology
Online-Zugang:	Volltext
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