Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

A significant and selective deficiency of ethanolamine plasmalogen (PPE) relative to phosphatidylethanolamine was identified in post mortem brain samples from patients with Alzheimer's disease (AD). This lipid defect showed anatomic specificity, being more marked at a site of neurodegeneration...

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Veröffentlicht in:	Brain research 1995-11, Vol.698 (1), p.223-226
Hauptverfasser:	Ginsberg, Lionel, Rafique, Samina, Xuereb, John H., Rapoport, Stanley I., Gershfeld, Norman L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - physiopathology Alzheimer's disease Biological and medical sciences Brain Caudate Nucleus - physiopathology Cerebellum - pathology Cerebellum - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Ethanolamine plasmalogen Humans Huntington Disease - pathology Huntington Disease - physiopathology Lipid Medical sciences Membrane Middle Aged Neurology Parkinson Disease - pathology Parkinson Disease - physiopathology Plasmalogens - physiology Substantia Nigra - physiopathology Temporal Lobe - pathology Temporal Lobe - physiopathology
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