Pharmacokinetics and metabolism of diltiazem in rats following a single intra-arterial or single oral dose

Diltiazem (DTZ) 20 mg/kg was given to male Sprague-Dawley rats either orally (p.o.) or intra-arterially (i.a.) over a 5 min period (n = 6 for each group). Plasma concentrations of DTZ and its major basic metabolites were determined by high performance liquid chromatography assay (HPLC) as previously...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1994-12, Vol.19 (4), p.369-373
Hauptverfasser:	TSUI, B. C. H, FENG, J. D. Z, BUCKLEY, S. J, YEUNG, P. K. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antihypertensive agents Biological and medical sciences Cardiovascular system Diltiazem - metabolism Diltiazem - pharmacokinetics Drug Administration Schedule Infusions, Intra-Arterial Male Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!