Ontogeny of two different benzodiazepine binding sites in the chick optic lobe
The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 1995-10, Vol.6 (15), p.2013-2016 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2016 |
|---|---|
| container_issue | 15 |
| container_start_page | 2013 |
| container_title | Neuroreport |
| container_volume | 6 |
| creator | Gravielle, Maria Clara de Plazas, Sara Fiszer |
| description | The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development. |
| doi_str_mv | 10.1097/00001756-199510010-00015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77822385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77822385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3305-aa4704b1c737cb0bd17c9f8e397491a9546775d42ada9d6efc904e495be9f8933</originalsourceid><addsrcrecordid>eNqFkcFuGyEQhlHVKnHSPkIlDlFvm8ACy84xipomkpVcWqk3xLKzNs0aHMCykqfvunZ8q8IFxP_NjPQNIZSzS85AX7HpcK2aigMoPr1ZtftRH8iMSy0qpdrfH8mMgYJKQqNOyVnOfyYEGG9PyEmrWiYFm5GHx1DiAsMLjQMt20h7PwyYMBTaYXiNvbevuPYBaedD78OCZl8wUx9oWSJ1S--eaFwX7-gYO_xMPg12zPjlcJ-TX7fff97cVfPHH_c31_PKCcFUZa3UTHbcaaFdx7qeawdDiwK0BG5ByUZr1cva9hb6BgcHTKIE1eGEgRDn5Nu-7zrF5w3mYlY-OxxHGzBustG6rWvRqndB3kADQu3Adg-6FHNOOJh18iubXgxnZufcvDk3R-fmn_Op9OthxqZbYX8sPEie8otDbrOz45BscD4fsRp4Pe1rwuQe28axYMpP42aLySzRjmVp_rdx8RcplJhZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16969355</pqid></control><display><type>article</type><title>Ontogeny of two different benzodiazepine binding sites in the chick optic lobe</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Gravielle, Maria Clara ; de Plazas, Sara Fiszer</creator><creatorcontrib>Gravielle, Maria Clara ; de Plazas, Sara Fiszer</creatorcontrib><description>The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199510010-00015</identifier><identifier>PMID: 8580430</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Anti-Anxiety Agents - pharmacology ; Binding Sites ; Biological and medical sciences ; Chickens ; Development. Senescence. Regeneration. Transplantation ; Flunitrazepam - metabolism ; Fundamental and applied biological sciences. Psychology ; Kinetics ; Pyridazines - pharmacology ; Receptors, GABA-A - metabolism ; Tectum Mesencephali - growth & development ; Tectum Mesencephali - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1995-10, Vol.6 (15), p.2013-2016</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3305-aa4704b1c737cb0bd17c9f8e397491a9546775d42ada9d6efc904e495be9f8933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2912558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8580430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gravielle, Maria Clara</creatorcontrib><creatorcontrib>de Plazas, Sara Fiszer</creatorcontrib><title>Ontogeny of two different benzodiazepine binding sites in the chick optic lobe</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Chickens</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Flunitrazepam - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Pyridazines - pharmacology</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Tectum Mesencephali - growth & development</subject><subject>Tectum Mesencephali - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuGyEQhlHVKnHSPkIlDlFvm8ACy84xipomkpVcWqk3xLKzNs0aHMCykqfvunZ8q8IFxP_NjPQNIZSzS85AX7HpcK2aigMoPr1ZtftRH8iMSy0qpdrfH8mMgYJKQqNOyVnOfyYEGG9PyEmrWiYFm5GHx1DiAsMLjQMt20h7PwyYMBTaYXiNvbevuPYBaedD78OCZl8wUx9oWSJ1S--eaFwX7-gYO_xMPg12zPjlcJ-TX7fff97cVfPHH_c31_PKCcFUZa3UTHbcaaFdx7qeawdDiwK0BG5ByUZr1cva9hb6BgcHTKIE1eGEgRDn5Nu-7zrF5w3mYlY-OxxHGzBustG6rWvRqndB3kADQu3Adg-6FHNOOJh18iubXgxnZufcvDk3R-fmn_Op9OthxqZbYX8sPEie8otDbrOz45BscD4fsRp4Pe1rwuQe28axYMpP42aLySzRjmVp_rdx8RcplJhZ</recordid><startdate>19951023</startdate><enddate>19951023</enddate><creator>Gravielle, Maria Clara</creator><creator>de Plazas, Sara Fiszer</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19951023</creationdate><title>Ontogeny of two different benzodiazepine binding sites in the chick optic lobe</title><author>Gravielle, Maria Clara ; de Plazas, Sara Fiszer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3305-aa4704b1c737cb0bd17c9f8e397491a9546775d42ada9d6efc904e495be9f8933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Chickens</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Flunitrazepam - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Pyridazines - pharmacology</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Tectum Mesencephali - growth & development</topic><topic>Tectum Mesencephali - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gravielle, Maria Clara</creatorcontrib><creatorcontrib>de Plazas, Sara Fiszer</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gravielle, Maria Clara</au><au>de Plazas, Sara Fiszer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogeny of two different benzodiazepine binding sites in the chick optic lobe</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1995-10-23</date><risdate>1995</risdate><volume>6</volume><issue>15</issue><spage>2013</spage><epage>2016</epage><pages>2013-2016</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8580430</pmid><doi>10.1097/00001756-199510010-00015</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1995-10, Vol.6 (15), p.2013-2016 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77822385 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Anti-Anxiety Agents - pharmacology Binding Sites Biological and medical sciences Chickens Development. Senescence. Regeneration. Transplantation Flunitrazepam - metabolism Fundamental and applied biological sciences. Psychology Kinetics Pyridazines - pharmacology Receptors, GABA-A - metabolism Tectum Mesencephali - growth & development Tectum Mesencephali - metabolism Vertebrates: nervous system and sense organs |
| title | Ontogeny of two different benzodiazepine binding sites in the chick optic lobe |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A22%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ontogeny%20of%20two%20different%20benzodiazepine%20binding%20sites%20in%20the%20chick%20optic%20lobe&rft.jtitle=Neuroreport&rft.au=Gravielle,%20Maria%20Clara&rft.date=1995-10-23&rft.volume=6&rft.issue=15&rft.spage=2013&rft.epage=2016&rft.pages=2013-2016&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-199510010-00015&rft_dat=%3Cproquest_cross%3E77822385%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16969355&rft_id=info:pmid/8580430&rfr_iscdi=true |