Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes
Haplotypes derived from five polymorphic restriction sites in the beta‐globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+−−−−) and 6 (−++−+) were the most frequ...
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| Veröffentlicht in: | American journal of physical anthropology 1995-12, Vol.98 (4), p.395-401 |
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| creator | Bevilaqua, Lia R. M. Mattevi, Vanessa S. Ewald, Gisele M. Salzano, Francisco M. Coimbra JR, Carlos E. A. Santos, Ricardo V. Hutz, Mara H. |
| description | Haplotypes derived from five polymorphic restriction sites in the beta‐globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+−−−−) and 6 (−++−+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozy‐gosity measured by the Gini‐Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST′) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi‐Mondé‐speaking tribes were considered, this estimate was reduced to 0.030. © 1995 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajpa.1330980402 |
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M. ; Mattevi, Vanessa S. ; Ewald, Gisele M. ; Salzano, Francisco M. ; Coimbra JR, Carlos E. A. ; Santos, Ricardo V. ; Hutz, Mara H.</creator><creatorcontrib>Bevilaqua, Lia R. M. ; Mattevi, Vanessa S. ; Ewald, Gisele M. ; Salzano, Francisco M. ; Coimbra JR, Carlos E. A. ; Santos, Ricardo V. ; Hutz, Mara H.</creatorcontrib><description>Haplotypes derived from five polymorphic restriction sites in the beta‐globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+−−−−) and 6 (−++−+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozy‐gosity measured by the Gini‐Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST′) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi‐Mondé‐speaking tribes were considered, this estimate was reduced to 0.030. © 1995 Wiley‐Liss, Inc.</description><identifier>ISSN: 0002-9483</identifier><identifier>EISSN: 1096-8644</identifier><identifier>DOI: 10.1002/ajpa.1330980402</identifier><identifier>PMID: 8599376</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Amerindians ; Base Sequence ; Brazil ; Brazil - ethnology ; DNA polymorphism ; Gene Frequency ; Genes ; Genetic diversity ; Genetic Variation ; Genetics ; Globins - genetics ; Haplotypes - genetics ; Hemoglobin ; Humans ; Indians, South American - genetics ; Molecular Sequence Data ; Multigene Family - genetics ; Physical anthropology ; South Amerindians</subject><ispartof>American journal of physical anthropology, 1995-12, Vol.98 (4), p.395-401</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3562-e6b8620eb6595ade1cfcb6c1ca7706805b8701a67ab6740c84fe9b7bed963fa53</citedby><cites>FETCH-LOGICAL-c3562-e6b8620eb6595ade1cfcb6c1ca7706805b8701a67ab6740c84fe9b7bed963fa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajpa.1330980402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajpa.1330980402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27848,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8599376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bevilaqua, Lia R. M.</creatorcontrib><creatorcontrib>Mattevi, Vanessa S.</creatorcontrib><creatorcontrib>Ewald, Gisele M.</creatorcontrib><creatorcontrib>Salzano, Francisco M.</creatorcontrib><creatorcontrib>Coimbra JR, Carlos E. A.</creatorcontrib><creatorcontrib>Santos, Ricardo V.</creatorcontrib><creatorcontrib>Hutz, Mara H.</creatorcontrib><title>Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes</title><title>American journal of physical anthropology</title><addtitle>Am. J. Phys. Anthropol</addtitle><description>Haplotypes derived from five polymorphic restriction sites in the beta‐globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+−−−−) and 6 (−++−+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozy‐gosity measured by the Gini‐Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST′) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi‐Mondé‐speaking tribes were considered, this estimate was reduced to 0.030. © 1995 Wiley‐Liss, Inc.</description><subject>Amerindians</subject><subject>Base Sequence</subject><subject>Brazil</subject><subject>Brazil - ethnology</subject><subject>DNA polymorphism</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Globins - genetics</subject><subject>Haplotypes - genetics</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Indians, South American - genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family - genetics</subject><subject>Physical anthropology</subject><subject>South Amerindians</subject><issn>0002-9483</issn><issn>1096-8644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqFkcFrFDEUh4NY6lo9exIGhN6mTSYzLwmetsXWtqtVrHoMSeZNzTo7MyYz6vrXN8suFb0UAo_wvt8PHh8hLxg9YpQWx2Y5mCPGOVWSlrR4RGaMKsgllOVjMqMJyVUp-RPyNMZl-kJ6-2RfVkpxATNyfYKjyW_b3vouu8UOM9dOccSQfTND24_rAbPaxzF4O42-77KENf4nZifB_PGtN1120dWbsUEwPiN7jWkjPt_NA_L57M3N6dt8cX1-cTpf5I5XUOQIVkJB0UKlKlMjc42z4JgzQlCQtLJSUGZAGAuipE6WDSorLNYKeGMqfkAOt71D6H9MGEe98tFh25oO-ylqIWTBlFAPglxKVTIlE_jqP3DZT6FLR2hWKGCqoACJOt5SLvQxBmz0EPzKhLVmVG-M6I0R_ddISrzc9U52hfU9v1OQ9q-3-1--xfVDdXp--WH-T3u-TSdH-Ps-bcJ3DYKLSn99f67fXX0svtycLfQnfgcyrqdd</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Bevilaqua, Lia R. 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M.</au><au>Mattevi, Vanessa S.</au><au>Ewald, Gisele M.</au><au>Salzano, Francisco M.</au><au>Coimbra JR, Carlos E. A.</au><au>Santos, Ricardo V.</au><au>Hutz, Mara H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes</atitle><jtitle>American journal of physical anthropology</jtitle><addtitle>Am. J. Phys. Anthropol</addtitle><date>1995-12</date><risdate>1995</risdate><volume>98</volume><issue>4</issue><spage>395</spage><epage>401</epage><pages>395-401</pages><issn>0002-9483</issn><eissn>1096-8644</eissn><abstract>Haplotypes derived from five polymorphic restriction sites in the beta‐globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 (+−−−−) and 6 (−++−+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozy‐gosity measured by the Gini‐Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST′) was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi‐Mondé‐speaking tribes were considered, this estimate was reduced to 0.030. © 1995 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8599376</pmid><doi>10.1002/ajpa.1330980402</doi><tpages>7</tpages></addata></record> |
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| subjects | Amerindians Base Sequence Brazil Brazil - ethnology DNA polymorphism Gene Frequency Genes Genetic diversity Genetic Variation Genetics Globins - genetics Haplotypes - genetics Hemoglobin Humans Indians, South American - genetics Molecular Sequence Data Multigene Family - genetics Physical anthropology South Amerindians |
| title | Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes |
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