ETA Receptors Mediate Activation of Phospholipases C and D In Rat Myometrium

In estrogen-treated rat myometrium, endothelial (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway (PLD) as evidenced in the presence of butanol by an increased production of phosphat...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1995, Vol.26 Suppl 3, p.S307-309
Hauptverfasser:	Dokhac, Lien, Stunff, Herve Le, Naze, Sandrine, Harbon, Simone
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endothelins - pharmacology Enzyme Activation Female Glycerophospholipids Myometrium - enzymology Phosphatidic Acids - biosynthesis Phospholipase D - metabolism Rats Receptor, Endothelin A Receptors, Endothelin - physiology Type C Phospholipases - metabolism Uterine Contraction - drug effects
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