Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus
alpha 1-Adrenergic and muscarinic cholinergic stimuli activate uterine contraction. Estrogen increases adrenergic but not cholinergic sensitivity of rabbit myometrium independent of its effects on adrenoceptor concentration. Since both alpha 1-adrenergic and muscarinic receptors are coupled to phosp...
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| Veröffentlicht in: | Molecular pharmacology 1987-11, Vol.32 (5), p.663-668 |
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| creator | RIEMER, R. K GOLDFIEN, A ROBERTS, J. M |
| description | alpha 1-Adrenergic and muscarinic cholinergic stimuli activate uterine contraction. Estrogen increases adrenergic but not
cholinergic sensitivity of rabbit myometrium independent of its effects on adrenoceptor concentration. Since both alpha 1-adrenergic
and muscarinic receptors are coupled to phosphatidylinositol hydrolysis, we tested the hypothesis that estrogen increases
adrenergic- but not cholinergic-mediated inositol triphosphate production. We found that maximal production of inositol phosphates
stimulated by norepinephrine was increased approximately 3-fold following estrogen treatment. Cholinergic-stimulated production
was not increased by estrogen treatment. These results demonstrate that the effect of estrogen to enhance uterine adrenergic
sensitivity is associated with an increased post-receptor response. The nature of the selectivity of estrogen for adrenergic
versus cholinergic response remains obscure, but the results suggest the presence of parallel pathways for receptor activation
of a common post-receptor response. |
| format | Article |
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cholinergic sensitivity of rabbit myometrium independent of its effects on adrenoceptor concentration. Since both alpha 1-adrenergic
and muscarinic receptors are coupled to phosphatidylinositol hydrolysis, we tested the hypothesis that estrogen increases
adrenergic- but not cholinergic-mediated inositol triphosphate production. We found that maximal production of inositol phosphates
stimulated by norepinephrine was increased approximately 3-fold following estrogen treatment. Cholinergic-stimulated production
was not increased by estrogen treatment. These results demonstrate that the effect of estrogen to enhance uterine adrenergic
sensitivity is associated with an increased post-receptor response. The nature of the selectivity of estrogen for adrenergic
versus cholinergic response remains obscure, but the results suggest the presence of parallel pathways for receptor activation
of a common post-receptor response.</description><identifier>ISSN: 0026-895X</identifier><identifier>EISSN: 1521-0111</identifier><identifier>PMID: 2824981</identifier><identifier>CODEN: MOPMA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Pharmacology and Experimental Therapeutics</publisher><subject>adrenergic ; Animals ; Biological and medical sciences ; Carbachol - pharmacology ; Estradiol - pharmacology ; estrogens ; Female ; Hormones. Endocrine system ; inositol 1,4,5-trisphosphate ; Inositol Phosphates - biosynthesis ; Kinetics ; Medical sciences ; Norepinephrine - pharmacology ; Ovariectomy ; Pharmacology. Drug treatments ; Prazosin - pharmacology ; Rabbits ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - physiology ; Receptors, Muscarinic - drug effects ; Receptors, Muscarinic - physiology ; Sugar Phosphates - biosynthesis ; Uterine Contraction - drug effects ; uterus ; Uterus - drug effects ; Uterus - metabolism ; Yohimbine - pharmacology</subject><ispartof>Molecular pharmacology, 1987-11, Vol.32 (5), p.663-668</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7832873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2824981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIEMER, R. K</creatorcontrib><creatorcontrib>GOLDFIEN, A</creatorcontrib><creatorcontrib>ROBERTS, J. M</creatorcontrib><title>Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus</title><title>Molecular pharmacology</title><addtitle>Mol Pharmacol</addtitle><description>alpha 1-Adrenergic and muscarinic cholinergic stimuli activate uterine contraction. Estrogen increases adrenergic but not
cholinergic sensitivity of rabbit myometrium independent of its effects on adrenoceptor concentration. Since both alpha 1-adrenergic
and muscarinic receptors are coupled to phosphatidylinositol hydrolysis, we tested the hypothesis that estrogen increases
adrenergic- but not cholinergic-mediated inositol triphosphate production. We found that maximal production of inositol phosphates
stimulated by norepinephrine was increased approximately 3-fold following estrogen treatment. Cholinergic-stimulated production
was not increased by estrogen treatment. These results demonstrate that the effect of estrogen to enhance uterine adrenergic
sensitivity is associated with an increased post-receptor response. The nature of the selectivity of estrogen for adrenergic
versus cholinergic response remains obscure, but the results suggest the presence of parallel pathways for receptor activation
of a common post-receptor response.</description><subject>adrenergic</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbachol - pharmacology</subject><subject>Estradiol - pharmacology</subject><subject>estrogens</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>inositol 1,4,5-trisphosphate</subject><subject>Inositol Phosphates - biosynthesis</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Norepinephrine - pharmacology</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>Prazosin - pharmacology</subject><subject>Rabbits</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Receptors, Muscarinic - physiology</subject><subject>Sugar Phosphates - biosynthesis</subject><subject>Uterine Contraction - drug effects</subject><subject>uterus</subject><subject>Uterus - drug effects</subject><subject>Uterus - metabolism</subject><subject>Yohimbine - pharmacology</subject><issn>0026-895X</issn><issn>1521-0111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAiyrqu_gQhB_VWyCRpmxxlWT9gwYuCt5Km022k26xJiuy_N7DFq-Qw8M7DEN6zbAkFg5wCwHm2pJSVuVTF52V2FcIXpSAKSRfZgkkmlIRlNm5C9G6HI7Gj8agDBqJbjyP6nTU5aaZIRheJ6d1g53CPrdURW3Lwrp1MtG4krksHXLDRDeTQu3DokwgpI143jY1kiuincJ1ddHoIeDPPVfbxtHlfv-Tbt-fX9eM27xlAzIGCSa9iEiuNtKm4MEoJiY0w2JVNUUAlGEgBDSsxZVJJKlXLeTIMFF9lD6e76YvfE4ZY720wOAx6RDeFuqokKMH-hyAUMAYswdsZTk0qoD54u9f-WM9Npv3dvNfB6KHzejQ2_LFKciYrntj9ifV21_9Yj3Vqyu-1cYPbHWvO6qIuS85_AUhQizk</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>RIEMER, R. K</creator><creator>GOLDFIEN, A</creator><creator>ROBERTS, J. M</creator><general>American Society for Pharmacology and Experimental Therapeutics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198711</creationdate><title>Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus</title><author>RIEMER, R. K ; GOLDFIEN, A ; ROBERTS, J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h211t-101c1c1728e7ae0b734c9948eb4cef6b5517421841b26e4ce898089d3348e2193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>adrenergic</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbachol - pharmacology</topic><topic>Estradiol - pharmacology</topic><topic>estrogens</topic><topic>Female</topic><topic>Hormones. Endocrine system</topic><topic>inositol 1,4,5-trisphosphate</topic><topic>Inositol Phosphates - biosynthesis</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Norepinephrine - pharmacology</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>Prazosin - pharmacology</topic><topic>Rabbits</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Receptors, Muscarinic - physiology</topic><topic>Sugar Phosphates - biosynthesis</topic><topic>Uterine Contraction - drug effects</topic><topic>uterus</topic><topic>Uterus - drug effects</topic><topic>Uterus - metabolism</topic><topic>Yohimbine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIEMER, R. K</creatorcontrib><creatorcontrib>GOLDFIEN, A</creatorcontrib><creatorcontrib>ROBERTS, J. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIEMER, R. K</au><au>GOLDFIEN, A</au><au>ROBERTS, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus</atitle><jtitle>Molecular pharmacology</jtitle><addtitle>Mol Pharmacol</addtitle><date>1987-11</date><risdate>1987</risdate><volume>32</volume><issue>5</issue><spage>663</spage><epage>668</epage><pages>663-668</pages><issn>0026-895X</issn><eissn>1521-0111</eissn><coden>MOPMA3</coden><abstract>alpha 1-Adrenergic and muscarinic cholinergic stimuli activate uterine contraction. Estrogen increases adrenergic but not
cholinergic sensitivity of rabbit myometrium independent of its effects on adrenoceptor concentration. Since both alpha 1-adrenergic
and muscarinic receptors are coupled to phosphatidylinositol hydrolysis, we tested the hypothesis that estrogen increases
adrenergic- but not cholinergic-mediated inositol triphosphate production. We found that maximal production of inositol phosphates
stimulated by norepinephrine was increased approximately 3-fold following estrogen treatment. Cholinergic-stimulated production
was not increased by estrogen treatment. These results demonstrate that the effect of estrogen to enhance uterine adrenergic
sensitivity is associated with an increased post-receptor response. The nature of the selectivity of estrogen for adrenergic
versus cholinergic response remains obscure, but the results suggest the presence of parallel pathways for receptor activation
of a common post-receptor response.</abstract><cop>Bethesda, MD</cop><pub>American Society for Pharmacology and Experimental Therapeutics</pub><pmid>2824981</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Molecular pharmacology, 1987-11, Vol.32 (5), p.663-668 |
| issn | 0026-895X 1521-0111 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | adrenergic Animals Biological and medical sciences Carbachol - pharmacology Estradiol - pharmacology estrogens Female Hormones. Endocrine system inositol 1,4,5-trisphosphate Inositol Phosphates - biosynthesis Kinetics Medical sciences Norepinephrine - pharmacology Ovariectomy Pharmacology. Drug treatments Prazosin - pharmacology Rabbits Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - physiology Receptors, Muscarinic - drug effects Receptors, Muscarinic - physiology Sugar Phosphates - biosynthesis Uterine Contraction - drug effects uterus Uterus - drug effects Uterus - metabolism Yohimbine - pharmacology |
| title | Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus |
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