Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds

Bisphosphines related to bis(diphenylphosphino)ethane (dppe) and their gold complexes are described that are active in a spectrum of transplantable tumor models. When administered ip on days 1-5 at its maximally tolerated dose (MTD) of 40 mumol/kg, dppe reproducibly gives 100% increase in life span...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-12, Vol.30 (12), p.2181-2190
Hauptverfasser:	Mirabelli, Christopher K, Hill, David T, Faucette, Leo F, McCabe, Francis L, Girard, Gerald R, Bryan, Deborah B, Sutton, Blaine M, Barus, Joan O. Leary, Crooke, Stanley T, Johnson, Randall K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences General pharmacology Gold - pharmacology Medical sciences Mice Molecular Conformation Neoplasms, Experimental - drug therapy Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Solubility Structure-Activity Relationship
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