Intestinal microsporidiosis with Septata intestinalis in a patient with AIDS—response to albendazole
Microsporidiosis is a common finding in HIV-infected patients who have diarrhoea. The species most commonly causing gastrointestinal disease is Enterocytozoon bieneusi. Recently Septata intestinalis has been described as a cause of diarrhoea and disseminated infection in patients with AIDS. A 44-yea...
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| Veröffentlicht in: | The Journal of infection 1995-11, Vol.31 (3), p.237-239 |
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| container_title | The Journal of infection |
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| creator | Franzen, C. Müller, A. Schwenk, A. Salzberger, B. Fätkenheuer, G. Mahrle, G. Diehl, V. Schrappe, M. |
| description | Microsporidiosis is a common finding in HIV-infected patients who have diarrhoea. The species most commonly causing gastrointestinal disease is Enterocytozoon bieneusi. Recently Septata intestinalis has been described as a cause of diarrhoea and disseminated infection in patients with AIDS. A 44-year-old homosexual man with severe immunodeficiency (CD4 cell count 40/μl) had a history of watery diarrhoea for 2 weeks. Microsporidian spores measuring 1·2 to 1·5 × 2·5 to 3·0 μm were found in stool samples. Electron microscopy of duodenal biopsies confirmed the diagnosis of intestinal microsporidiosis and showed parasitophorous vacuoles with the typical ultrastructure of S. intestinalis. The patient was treated with albendazole (400 mg twice daily) and became asymptomatic within 4 days. No spores could be detected in stool samples after a treatment period of 14 days. About 25 infections with S. intestinalis have been reported to date, and the case presented here is the first in a German patient. |
| doi_str_mv | 10.1016/S0163-4453(95)80034-4 |
| format | Article |
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The species most commonly causing gastrointestinal disease is Enterocytozoon bieneusi. Recently Septata intestinalis has been described as a cause of diarrhoea and disseminated infection in patients with AIDS. A 44-year-old homosexual man with severe immunodeficiency (CD4 cell count 40/μl) had a history of watery diarrhoea for 2 weeks. Microsporidian spores measuring 1·2 to 1·5 × 2·5 to 3·0 μm were found in stool samples. Electron microscopy of duodenal biopsies confirmed the diagnosis of intestinal microsporidiosis and showed parasitophorous vacuoles with the typical ultrastructure of S. intestinalis. The patient was treated with albendazole (400 mg twice daily) and became asymptomatic within 4 days. No spores could be detected in stool samples after a treatment period of 14 days. About 25 infections with S. intestinalis have been reported to date, and the case presented here is the first in a German patient.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/S0163-4453(95)80034-4</identifier><identifier>PMID: 8586846</identifier><identifier>CODEN: JINFD2</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Adult ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - parasitology ; AIDS/HIV ; Albendazole - therapeutic use ; Animals ; Anthelmintics - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biological and medical sciences ; Diarrhea - drug therapy ; Diarrhea - parasitology ; Homosexuality, Male ; human immunodeficiency virus ; Humans ; Male ; Medical sciences ; Microscopy, Electron ; Microsporidia - growth & development ; Microsporidia - ultrastructure ; Microsporidiosis - drug therapy ; Microsporidiosis - parasitology ; Pharmacology. 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The species most commonly causing gastrointestinal disease is Enterocytozoon bieneusi. Recently Septata intestinalis has been described as a cause of diarrhoea and disseminated infection in patients with AIDS. A 44-year-old homosexual man with severe immunodeficiency (CD4 cell count 40/μl) had a history of watery diarrhoea for 2 weeks. Microsporidian spores measuring 1·2 to 1·5 × 2·5 to 3·0 μm were found in stool samples. Electron microscopy of duodenal biopsies confirmed the diagnosis of intestinal microsporidiosis and showed parasitophorous vacuoles with the typical ultrastructure of S. intestinalis. The patient was treated with albendazole (400 mg twice daily) and became asymptomatic within 4 days. No spores could be detected in stool samples after a treatment period of 14 days. About 25 infections with S. intestinalis have been reported to date, and the case presented here is the first in a German patient.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - parasitology</subject><subject>AIDS/HIV</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Diarrhea - drug therapy</subject><subject>Diarrhea - parasitology</subject><subject>Homosexuality, Male</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Microsporidia - growth & development</subject><subject>Microsporidia - ultrastructure</subject><subject>Microsporidiosis - drug therapy</subject><subject>Microsporidiosis - parasitology</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franzen, C.</creatorcontrib><creatorcontrib>Müller, A.</creatorcontrib><creatorcontrib>Schwenk, A.</creatorcontrib><creatorcontrib>Salzberger, B.</creatorcontrib><creatorcontrib>Fätkenheuer, G.</creatorcontrib><creatorcontrib>Mahrle, G.</creatorcontrib><creatorcontrib>Diehl, V.</creatorcontrib><creatorcontrib>Schrappe, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franzen, C.</au><au>Müller, A.</au><au>Schwenk, A.</au><au>Salzberger, B.</au><au>Fätkenheuer, G.</au><au>Mahrle, G.</au><au>Diehl, V.</au><au>Schrappe, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal microsporidiosis with Septata intestinalis in a patient with AIDS—response to albendazole</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>31</volume><issue>3</issue><spage>237</spage><epage>239</epage><pages>237-239</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><coden>JINFD2</coden><abstract>Microsporidiosis is a common finding in HIV-infected patients who have diarrhoea. The species most commonly causing gastrointestinal disease is Enterocytozoon bieneusi. Recently Septata intestinalis has been described as a cause of diarrhoea and disseminated infection in patients with AIDS. A 44-year-old homosexual man with severe immunodeficiency (CD4 cell count 40/μl) had a history of watery diarrhoea for 2 weeks. Microsporidian spores measuring 1·2 to 1·5 × 2·5 to 3·0 μm were found in stool samples. Electron microscopy of duodenal biopsies confirmed the diagnosis of intestinal microsporidiosis and showed parasitophorous vacuoles with the typical ultrastructure of S. intestinalis. The patient was treated with albendazole (400 mg twice daily) and became asymptomatic within 4 days. No spores could be detected in stool samples after a treatment period of 14 days. About 25 infections with S. intestinalis have been reported to date, and the case presented here is the first in a German patient.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>8586846</pmid><doi>10.1016/S0163-4453(95)80034-4</doi><tpages>3</tpages></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - complications Adult AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - parasitology AIDS/HIV Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Diarrhea - drug therapy Diarrhea - parasitology Homosexuality, Male human immunodeficiency virus Humans Male Medical sciences Microscopy, Electron Microsporidia - growth & development Microsporidia - ultrastructure Microsporidiosis - drug therapy Microsporidiosis - parasitology Pharmacology. Drug treatments |
| title | Intestinal microsporidiosis with Septata intestinalis in a patient with AIDS—response to albendazole |
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