Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks
The structure of a new functional variant B27d has been established by comparative peptide mapping and radiochemical sequencing. This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change betwe...
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| Veröffentlicht in: | The Journal of immunology (1950) 1987-11, Vol.139 (10), p.3396-3401 |
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| container_issue | 10 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 139 |
| creator | Rojo, S Aparicio, P Hansen, JA Choo, SY Lopez de Castro, JA |
| description | The structure of a new functional variant B27d has been established by comparative peptide mapping and radiochemical sequencing. This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change between the main HLA-B27.1 subtype and B27d is that of Tyr59 to His59. Position 59 has not been previously found to vary among class I HLA or H-2 antigens. Such substitution accounts for the reported isoelectric focusing pattern of this variant. HLA-B27d is the only B27 variant found to differ from other subtypes by a single amino acid replacement. The nature of the change is compatible with its origin by a point mutation from HLA-B27.1. Because B27d was found only in American blacks and in no other ethnic groups, it is suggested that this variant originated as a result of a mutation of the B27.1 gene that occurred within the black population. |
| doi_str_mv | 10.4049/jimmunol.139.10.3396 |
| format | Article |
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This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change between the main HLA-B27.1 subtype and B27d is that of Tyr59 to His59. Position 59 has not been previously found to vary among class I HLA or H-2 antigens. Such substitution accounts for the reported isoelectric focusing pattern of this variant. HLA-B27d is the only B27 variant found to differ from other subtypes by a single amino acid replacement. The nature of the change is compatible with its origin by a point mutation from HLA-B27.1. Because B27d was found only in American blacks and in no other ethnic groups, it is suggested that this variant originated as a result of a mutation of the B27.1 gene that occurred within the black population.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.139.10.3396</identifier><identifier>PMID: 3500219</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Amino Acid Sequence ; Applied sciences ; Black or African American ; Black People ; Ethnicity ; Exact sciences and technology ; HLA Antigens - analysis ; HLA-B27 Antigen ; Humans ; Isoelectric Focusing ; Mutation ; Other techniques and industries ; United States ; West Indies</subject><ispartof>The Journal of immunology (1950), 1987-11, Vol.139 (10), p.3396-3401</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-f94925bcd8ed97b665497fccc733d5f823edac77eb9f74d1656972a68c48bc483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7072364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3500219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rojo, S</creatorcontrib><creatorcontrib>Aparicio, P</creatorcontrib><creatorcontrib>Hansen, JA</creatorcontrib><creatorcontrib>Choo, SY</creatorcontrib><creatorcontrib>Lopez de Castro, JA</creatorcontrib><title>Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The structure of a new functional variant B27d has been established by comparative peptide mapping and radiochemical sequencing. This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change between the main HLA-B27.1 subtype and B27d is that of Tyr59 to His59. Position 59 has not been previously found to vary among class I HLA or H-2 antigens. Such substitution accounts for the reported isoelectric focusing pattern of this variant. HLA-B27d is the only B27 variant found to differ from other subtypes by a single amino acid replacement. The nature of the change is compatible with its origin by a point mutation from HLA-B27.1. Because B27d was found only in American blacks and in no other ethnic groups, it is suggested that this variant originated as a result of a mutation of the B27.1 gene that occurred within the black population.</description><subject>Amino Acid Sequence</subject><subject>Applied sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Ethnicity</subject><subject>Exact sciences and technology</subject><subject>HLA Antigens - analysis</subject><subject>HLA-B27 Antigen</subject><subject>Humans</subject><subject>Isoelectric Focusing</subject><subject>Mutation</subject><subject>Other techniques and industries</subject><subject>United States</subject><subject>West Indies</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUMtKxDAUDaLo-PgDhSxEXNgxadKkWY7iCwZcqLgMaR4aTVtNWgf_3gwziotLLud1yQHgEKMpRVScv_m2Hbs-TDER0wwSItgGmOCqQgVjiG2CCUJlWWDO-A7YTekNIcRQSbfBNqkyhcUEPD8McdTDGFWAqlPhO_kEe5d3eDufFRclh27s9OD7TMIvFb3qhjOYcXMGjR2sHqyBvoOz1kavs60JSr-nfbDlVEj2YP3ugafrq8fL22J-f3N3OZsXmmI0FE5QUVaNNrU1gjeMVVRwp7XmhJjK1SWxRmnObSMcpwazigleKlZrWjd5yB44WeV-xP5ztGmQrU_ahqA6249Jcl5jkn-ahXQl1LFPKVonP6JvVfyWGMlln_K3T5n7XILLPrPtaJ0_Nq01f6Z1gZk_XvMqaRVcVJ326U_GES8Jo1l2upK9-pfXhY9WplaFkEOxXCwW_y_-AC_pjMg</recordid><startdate>19871115</startdate><enddate>19871115</enddate><creator>Rojo, S</creator><creator>Aparicio, P</creator><creator>Hansen, JA</creator><creator>Choo, SY</creator><creator>Lopez de Castro, JA</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871115</creationdate><title>Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks</title><author>Rojo, S ; Aparicio, P ; Hansen, JA ; Choo, SY ; Lopez de Castro, JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-f94925bcd8ed97b665497fccc733d5f823edac77eb9f74d1656972a68c48bc483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Amino Acid Sequence</topic><topic>Applied sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Ethnicity</topic><topic>Exact sciences and technology</topic><topic>HLA Antigens - analysis</topic><topic>HLA-B27 Antigen</topic><topic>Humans</topic><topic>Isoelectric Focusing</topic><topic>Mutation</topic><topic>Other techniques and industries</topic><topic>United States</topic><topic>West Indies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rojo, S</creatorcontrib><creatorcontrib>Aparicio, P</creatorcontrib><creatorcontrib>Hansen, JA</creatorcontrib><creatorcontrib>Choo, SY</creatorcontrib><creatorcontrib>Lopez de Castro, JA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rojo, S</au><au>Aparicio, P</au><au>Hansen, JA</au><au>Choo, SY</au><au>Lopez de Castro, JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1987-11-15</date><risdate>1987</risdate><volume>139</volume><issue>10</issue><spage>3396</spage><epage>3401</epage><pages>3396-3401</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>The structure of a new functional variant B27d has been established by comparative peptide mapping and radiochemical sequencing. This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change between the main HLA-B27.1 subtype and B27d is that of Tyr59 to His59. Position 59 has not been previously found to vary among class I HLA or H-2 antigens. Such substitution accounts for the reported isoelectric focusing pattern of this variant. HLA-B27d is the only B27 variant found to differ from other subtypes by a single amino acid replacement. The nature of the change is compatible with its origin by a point mutation from HLA-B27.1. Because B27d was found only in American blacks and in no other ethnic groups, it is suggested that this variant originated as a result of a mutation of the B27.1 gene that occurred within the black population.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>3500219</pmid><doi>10.4049/jimmunol.139.10.3396</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 1987-11, Vol.139 (10), p.3396-3401 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Applied sciences Black or African American Black People Ethnicity Exact sciences and technology HLA Antigens - analysis HLA-B27 Antigen Humans Isoelectric Focusing Mutation Other techniques and industries United States West Indies |
| title | Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks |
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