Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans
Concerns have recently been expressed at suggestions that postoperative sepsis may be more common in patients who have received preoperative total parenteral nutrition (TPN). The mechanism suggested for this is that TPN causes intestinal mucosal atrophy leading to increased bacterial translocation f...
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| Veröffentlicht in: | British journal of surgery 1995-12, Vol.82 (12), p.1663-1667 |
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| container_end_page | 1667 |
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| container_issue | 12 |
| container_start_page | 1663 |
| container_title | British journal of surgery |
| container_volume | 82 |
| creator | Sedman, P. C. Macfie, J. Palmer, M. D. Mitchell, C. J. Sagar, P. M. |
| description | Concerns have recently been expressed at suggestions that postoperative sepsis may be more common in patients who have received preoperative total parenteral nutrition (TPN). The mechanism suggested for this is that TPN causes intestinal mucosal atrophy leading to increased bacterial translocation from the gut as a source of systemic sepsis. This hypothesis was examined in 203 patients who had an elective laparotomy, 28 of whom required at least 10 days of preoperative TPN. Neither mucosal atrophy nor bacterial translocation was more common in parenterally fed patients than in enterally fed controls. In humans theoretical concerns about the adverse effects of TPN on intestinal integrity are unfounded. |
| doi_str_mv | 10.1002/bjs.1800821226 |
| format | Article |
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Neither mucosal atrophy nor bacterial translocation was more common in parenterally fed patients than in enterally fed controls. In humans theoretical concerns about the adverse effects of TPN on intestinal integrity are unfounded.</description><subject>Atrophy - etiology</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bacterial Infections - etiology</subject><subject>Bacterial Translocation</subject><subject>Biological and medical sciences</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parenteral Nutrition, Total - adverse effects</subject><subject>Preoperative Care - adverse effects</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUc1rFDEUD6LUtXr1JuQgvU3NdyZHLbZVii1YFbyETOYtmzozGZNM6_73puyyPb283xe8_BB6S8kpJYR96O7yKW0JaRllTD1DK8qVbBhV7XO0IoTohnLGX6JXOd8RQjmR7AgdtVK0jMsVyjcJ4gzJlXAPuMTiBjy7BFOp2ICnpaRQQpxwyHiKBbucow-uQI8fQtngcfExV6ErKc6bLY4Jd85Xc6hgSW7KQ_RulzDhzTJW5DV6sXZDhjf7eYx-nH--Pbtsrq4vvpx9vGo8V61q2Fpr2gHphTGsQt4bDwJcfbTaUc07CXWrs1d6bagRWgjjq0yJHgjwY3Syy51T_LtALnYM2cMwuAnikq3WLWVG0Sp8txcu3Qi9nVMYXdra_S9V_v2ed9m7YV3P8iEfZMxIacRjjNnJHsIA2wNNiX1sytam7FNT9tPX709b9TY7b8gF_h28Lv2x9UIt7a9vF_a3-snl7aWw5_w_h7uZJw</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Sedman, P. 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M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3686-2f771be0d4992c36cc9ce4ea6cc87a173b5eea673bd67f91947449ccc964de0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Atrophy - etiology</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Bacterial Infections - etiology</topic><topic>Bacterial Translocation</topic><topic>Biological and medical sciences</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parenteral Nutrition, Total - adverse effects</topic><topic>Preoperative Care - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedman, P. C.</creatorcontrib><creatorcontrib>Macfie, J.</creatorcontrib><creatorcontrib>Palmer, M. D.</creatorcontrib><creatorcontrib>Mitchell, C. J.</creatorcontrib><creatorcontrib>Sagar, P. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedman, P. C.</au><au>Macfie, J.</au><au>Palmer, M. D.</au><au>Mitchell, C. J.</au><au>Sagar, P. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1995-12</date><risdate>1995</risdate><volume>82</volume><issue>12</issue><spage>1663</spage><epage>1667</epage><pages>1663-1667</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Concerns have recently been expressed at suggestions that postoperative sepsis may be more common in patients who have received preoperative total parenteral nutrition (TPN). The mechanism suggested for this is that TPN causes intestinal mucosal atrophy leading to increased bacterial translocation from the gut as a source of systemic sepsis. This hypothesis was examined in 203 patients who had an elective laparotomy, 28 of whom required at least 10 days of preoperative TPN. Neither mucosal atrophy nor bacterial translocation was more common in parenterally fed patients than in enterally fed controls. In humans theoretical concerns about the adverse effects of TPN on intestinal integrity are unfounded.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8548235</pmid><doi>10.1002/bjs.1800821226</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of surgery, 1995-12, Vol.82 (12), p.1663-1667 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | Wiley; MEDLINE |
| subjects | Atrophy - etiology Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Infections - etiology Bacterial Translocation Biological and medical sciences Critical Illness Female Human bacterial diseases Humans Infectious diseases Intestinal Mucosa - pathology Male Medical sciences Middle Aged Parenteral Nutrition, Total - adverse effects Preoperative Care - adverse effects |
| title | Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans |
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