Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat

Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11),...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1994, Vol.15 (8), p.1445-1449
Hauptverfasser:	Schilero, Gregory J., Almenoff, Peter, Cardozo, Christopher, Lesser, Marvin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Amino Acid Sequence Angiotensin-converting enzyme Animals Bradykinin Bradykinin - pharmacology Bronchoconstriction - drug effects Bronchoconstriction - physiology Enalaprilat Enalaprilat - administration & dosage Enalaprilat - pharmacology Endopeptidase 24.11 Glycopeptides - administration & dosage Glycopeptides - pharmacology Kininases Kinins Male Maximal Expiratory Flow Rate - drug effects Metallopeptidases Molecular Sequence Data Neprilysin - antagonists & inhibitors Phosphoramidon Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley Respiration - drug effects Tidal Volume - drug effects Time Factors
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