Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat
Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11),...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1994, Vol.15 (8), p.1445-1449 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Schilero, Gregory J. Almenoff, Peter Cardozo, Christopher Lesser, Marvin |
| description | Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways. |
| doi_str_mv | 10.1016/0196-9781(94)90122-8 |
| format | Article |
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We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(94)90122-8</identifier><identifier>PMID: 7700846</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aerosols ; Amino Acid Sequence ; Angiotensin-converting enzyme ; Animals ; Bradykinin ; Bradykinin - pharmacology ; Bronchoconstriction - drug effects ; Bronchoconstriction - physiology ; Enalaprilat ; Enalaprilat - administration & dosage ; Enalaprilat - pharmacology ; Endopeptidase 24.11 ; Glycopeptides - administration & dosage ; Glycopeptides - pharmacology ; Kininases ; Kinins ; Male ; Maximal Expiratory Flow Rate - drug effects ; Metallopeptidases ; Molecular Sequence Data ; Neprilysin - antagonists & inhibitors ; Phosphoramidon ; Protease Inhibitors - pharmacology ; Rats ; Rats, Sprague-Dawley ; Respiration - drug effects ; Tidal Volume - drug effects ; Time Factors</subject><ispartof>Peptides (New York, N.Y. : 1980), 1994, Vol.15 (8), p.1445-1449</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b092f187de86cc188db6686593a66a958e0b6db5fddafb8de78d4ccdf2e8f8a33</citedby><cites>FETCH-LOGICAL-c357t-b092f187de86cc188db6686593a66a958e0b6db5fddafb8de78d4ccdf2e8f8a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(94)90122-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7700846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schilero, Gregory J.</creatorcontrib><creatorcontrib>Almenoff, Peter</creatorcontrib><creatorcontrib>Cardozo, Christopher</creatorcontrib><creatorcontrib>Lesser, Marvin</creatorcontrib><title>Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.</description><subject>Aerosols</subject><subject>Amino Acid Sequence</subject><subject>Angiotensin-converting enzyme</subject><subject>Animals</subject><subject>Bradykinin</subject><subject>Bradykinin - pharmacology</subject><subject>Bronchoconstriction - drug effects</subject><subject>Bronchoconstriction - physiology</subject><subject>Enalaprilat</subject><subject>Enalaprilat - administration & dosage</subject><subject>Enalaprilat - pharmacology</subject><subject>Endopeptidase 24.11</subject><subject>Glycopeptides - administration & dosage</subject><subject>Glycopeptides - pharmacology</subject><subject>Kininases</subject><subject>Kinins</subject><subject>Male</subject><subject>Maximal Expiratory Flow Rate - drug effects</subject><subject>Metallopeptidases</subject><subject>Molecular Sequence Data</subject><subject>Neprilysin - antagonists & inhibitors</subject><subject>Phosphoramidon</subject><subject>Protease Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiration - drug effects</subject><subject>Tidal Volume - drug effects</subject><subject>Time Factors</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcKeRA-ryX5kk4sgxS8oeKnnkE0mNNoma5IK_femtvToaWDed96ZeRC6JPiOYELvMeG05B0jN7y55ZhUVcmO0Jiwri5bQvkxGh8sp-gsxk-McdNwNkKjrsOYNXSM5k_GgEqx8KYYYEhWywiFdQvb2-RD7ruiD1JvvqyzrrROrxXo3PJOLbzyLqZgVbLZZl2RFlAEmc7RiZHLCBf7OkEfz0_z6Ws5e395mz7OSlW3XSp7zCuTz9XAqFKEMd1TymjLa0mp5C0D3FPdt0ZraXqmoWO6UUqbCphhsq4n6HqXOwT_vYaYxMpGBculdODXUXT58yqzysZmZ1TBxxjAiCHYlQwbQbDYwhRbUmJLSvBG_MEULI9d7fPX_Qr0YWhPL-sPOx3ykz8WgojKgsuAbMhQhfb2_wW_y8yFxA</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Schilero, Gregory J.</creator><creator>Almenoff, Peter</creator><creator>Cardozo, Christopher</creator><creator>Lesser, Marvin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat</title><author>Schilero, Gregory J. ; Almenoff, Peter ; Cardozo, Christopher ; Lesser, Marvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b092f187de86cc188db6686593a66a958e0b6db5fddafb8de78d4ccdf2e8f8a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aerosols</topic><topic>Amino Acid Sequence</topic><topic>Angiotensin-converting enzyme</topic><topic>Animals</topic><topic>Bradykinin</topic><topic>Bradykinin - pharmacology</topic><topic>Bronchoconstriction - drug effects</topic><topic>Bronchoconstriction - physiology</topic><topic>Enalaprilat</topic><topic>Enalaprilat - administration & dosage</topic><topic>Enalaprilat - pharmacology</topic><topic>Endopeptidase 24.11</topic><topic>Glycopeptides - administration & dosage</topic><topic>Glycopeptides - pharmacology</topic><topic>Kininases</topic><topic>Kinins</topic><topic>Male</topic><topic>Maximal Expiratory Flow Rate - drug effects</topic><topic>Metallopeptidases</topic><topic>Molecular Sequence Data</topic><topic>Neprilysin - antagonists & inhibitors</topic><topic>Phosphoramidon</topic><topic>Protease Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiration - drug effects</topic><topic>Tidal Volume - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schilero, Gregory J.</creatorcontrib><creatorcontrib>Almenoff, Peter</creatorcontrib><creatorcontrib>Cardozo, Christopher</creatorcontrib><creatorcontrib>Lesser, Marvin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schilero, Gregory J.</au><au>Almenoff, Peter</au><au>Cardozo, Christopher</au><au>Lesser, Marvin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1994</date><risdate>1994</risdate><volume>15</volume><issue>8</issue><spage>1445</spage><epage>1449</epage><pages>1445-1449</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7700846</pmid><doi>10.1016/0196-9781(94)90122-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1994, Vol.15 (8), p.1445-1449 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aerosols Amino Acid Sequence Angiotensin-converting enzyme Animals Bradykinin Bradykinin - pharmacology Bronchoconstriction - drug effects Bronchoconstriction - physiology Enalaprilat Enalaprilat - administration & dosage Enalaprilat - pharmacology Endopeptidase 24.11 Glycopeptides - administration & dosage Glycopeptides - pharmacology Kininases Kinins Male Maximal Expiratory Flow Rate - drug effects Metallopeptidases Molecular Sequence Data Neprilysin - antagonists & inhibitors Phosphoramidon Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley Respiration - drug effects Tidal Volume - drug effects Time Factors |
| title | Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat |
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