Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
Previous studies by our laboratory established a rat model of neuropathic pain which displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically maintained. The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongo...
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| Veröffentlicht in: | Pain (Amsterdam) 1994-12, Vol.59 (3), p.369-376 |
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| creator | Yoon, Choi Young Wook, Yoon Heung Sik, Na Sun Ho, Kim Jin Mo, Chung |
| description | Previous studies by our laboratory established a rat model of neuropathic pain which displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically maintained. The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongoing pain and cold allodynia in our animal model and testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of heat hyperalgesia and mechanical allodynia observed before, these rats displayed signs of ongoing pain (lasting at least 10 weeks) and cold allodynia (lasting at least 16 weeks). These behaviors were reduced markedly after surgical lumbar sympathectomy. The results of the present study, together with the previous study, suggest that our animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynia. Since all of these behavioral signs are sympathetically maintained, our model represents a model for sympathetically maintained pain. |
| doi_str_mv | 10.1016/0304-3959(94)90023-X |
| format | Article |
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The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongoing pain and cold allodynia in our animal model and testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of heat hyperalgesia and mechanical allodynia observed before, these rats displayed signs of ongoing pain (lasting at least 10 weeks) and cold allodynia (lasting at least 16 weeks). These behaviors were reduced markedly after surgical lumbar sympathectomy. The results of the present study, together with the previous study, suggest that our animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynia. Since all of these behavioral signs are sympathetically maintained, our model represents a model for sympathetically maintained pain.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(94)90023-X</identifier><identifier>PMID: 7708411</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Causalgia ; Cold Temperature ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Denervation ; Disease Models, Animal ; Foot - innervation ; Hyperalgesia ; Hyperalgesia - psychology ; Male ; Mechanical allodynia ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Pain - psychology ; Peripheral nerve injury ; Peripheral Nervous System Diseases - psychology ; Physical Stimulation ; Rats ; Rats, Sprague-Dawley ; Reflex - drug effects ; Spinal Nerves - physiology ; Sympathectomy ; Sympathetically maintained pain</subject><ispartof>Pain (Amsterdam), 1994-12, Vol.59 (3), p.369-376</ispartof><rights>1994</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5487-cfa50518cba452bb55705b34dd9733b30962c636ff59057bc20a64ef3dbc42c73</citedby><cites>FETCH-LOGICAL-c5487-cfa50518cba452bb55705b34dd9733b30962c636ff59057bc20a64ef3dbc42c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3959(94)90023-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3354358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7708411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Choi</creatorcontrib><creatorcontrib>Young Wook, Yoon</creatorcontrib><creatorcontrib>Heung Sik, Na</creatorcontrib><creatorcontrib>Sun Ho, Kim</creatorcontrib><creatorcontrib>Jin Mo, Chung</creatorcontrib><title>Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>Previous studies by our laboratory established a rat model of neuropathic pain which displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically maintained. The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongoing pain and cold allodynia in our animal model and testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of heat hyperalgesia and mechanical allodynia observed before, these rats displayed signs of ongoing pain (lasting at least 10 weeks) and cold allodynia (lasting at least 16 weeks). These behaviors were reduced markedly after surgical lumbar sympathectomy. The results of the present study, together with the previous study, suggest that our animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynia. Since all of these behavioral signs are sympathetically maintained, our model represents a model for sympathetically maintained pain.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Causalgia</subject><subject>Cold Temperature</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Denervation</subject><subject>Disease Models, Animal</subject><subject>Foot - innervation</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - psychology</subject><subject>Male</subject><subject>Mechanical allodynia</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pain - psychology</subject><subject>Peripheral nerve injury</subject><subject>Peripheral Nervous System Diseases - psychology</subject><subject>Physical Stimulation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex - drug effects</subject><subject>Spinal Nerves - physiology</subject><subject>Sympathectomy</subject><subject>Sympathetically maintained pain</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuPFCEURonRjO3oP9CEhTG6KOVNsTHRia9kEjdqZkduAdWN0tAD1TOZf2_VdKfduSLc-50LHBB6TslbSqh6RzgRHTfSvDbijSGE8e7qAVrRXrNOKcYfotUp8hg9ae03mUOMmTN0pjXpBaUr9Otj2MBNLBUSbnGdGy4jLnldYl7jHcSMIXvsSvIYUir-LkfASxVXmPC2-JAWIod9LTuYNtHdU0_RoxFSC8-O6zn6-fnTj4uv3eX3L98uPlx2Toped24ESSTt3QBCsmGQUhM5cOG90ZwPnBjFnOJqHKUhUg-OEVAijNwPTjCn-Tl6dZi7q-V6H9pkt7G5kBLkUPbNat1TapScg-IQdLW0VsNodzVuod5ZSuyi0y6u7OLKGmHvddqrGXtxnL8ftsGfoKO_uf_y2IfmII0VsovtFONcCi77f6ffljSF2v6k_W2odhMgTRs7fwtR3KiOGiMom3fdUlpe9_6AhVnhTZyJ5mLILvhYg5usL_H_1_8LwFif8g</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Yoon, Choi</creator><creator>Young Wook, Yoon</creator><creator>Heung Sik, Na</creator><creator>Sun Ho, Kim</creator><creator>Jin Mo, Chung</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain</title><author>Yoon, Choi ; Young Wook, Yoon ; Heung Sik, Na ; Sun Ho, Kim ; Jin Mo, Chung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5487-cfa50518cba452bb55705b34dd9733b30962c636ff59057bc20a64ef3dbc42c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Causalgia</topic><topic>Cold Temperature</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Denervation</topic><topic>Disease Models, Animal</topic><topic>Foot - innervation</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - psychology</topic><topic>Male</topic><topic>Mechanical allodynia</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pain - psychology</topic><topic>Peripheral nerve injury</topic><topic>Peripheral Nervous System Diseases - psychology</topic><topic>Physical Stimulation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex - drug effects</topic><topic>Spinal Nerves - physiology</topic><topic>Sympathectomy</topic><topic>Sympathetically maintained pain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Choi</creatorcontrib><creatorcontrib>Young Wook, Yoon</creatorcontrib><creatorcontrib>Heung Sik, Na</creatorcontrib><creatorcontrib>Sun Ho, Kim</creatorcontrib><creatorcontrib>Jin Mo, Chung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Choi</au><au>Young Wook, Yoon</au><au>Heung Sik, Na</au><au>Sun Ho, Kim</au><au>Jin Mo, Chung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>59</volume><issue>3</issue><spage>369</spage><epage>376</epage><pages>369-376</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>Previous studies by our laboratory established a rat model of neuropathic pain which displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically maintained. The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongoing pain and cold allodynia in our animal model and testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of heat hyperalgesia and mechanical allodynia observed before, these rats displayed signs of ongoing pain (lasting at least 10 weeks) and cold allodynia (lasting at least 16 weeks). These behaviors were reduced markedly after surgical lumbar sympathectomy. The results of the present study, together with the previous study, suggest that our animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynia. Since all of these behavioral signs are sympathetically maintained, our model represents a model for sympathetically maintained pain.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7708411</pmid><doi>10.1016/0304-3959(94)90023-X</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Behavior, Animal - physiology Biological and medical sciences Causalgia Cold Temperature Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Denervation Disease Models, Animal Foot - innervation Hyperalgesia Hyperalgesia - psychology Male Mechanical allodynia Medical sciences Nervous system (semeiology, syndromes) Neurology Pain - psychology Peripheral nerve injury Peripheral Nervous System Diseases - psychology Physical Stimulation Rats Rats, Sprague-Dawley Reflex - drug effects Spinal Nerves - physiology Sympathectomy Sympathetically maintained pain |
| title | Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain |
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