Solution hybridization of crosslinkable DNA oligonucleotides to bacteriophage M13 DNA: Effect of secondary structure on hybridization kinetics and equilibria

Several DNA oligonucleotides have been photochemically modified with the furocoumarin 4′-hydroxymethyl-4,5′,8-trimethylpsoralen (HMT) such that each contained a single HMT furan side monoadduct to thymidine at a unique 5′ TpA 3′ sequence. When these oligonucleotides were hybridized to their respecti...

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Veröffentlicht in:	Journal of molecular biology 1987-09, Vol.197 (2), p.349-362
Hauptverfasser:	Gamper, Howard B., Cimino, George D., Hearst, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophages - analysis DNA, Circular - metabolism DNA, Single-Stranded - metabolism DNA, Viral - metabolism Escherichia coli Kinetics Nucleic Acid Conformation Nucleic Acid Hybridization Oligodeoxyribonucleotides - metabolism phage M13 Temperature Trioxsalen - analogs & derivatives Trioxsalen - pharmacology
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