Angiotensin II Receptor Subtypes and Cardiac Function
All the components of the renin-angiotensin system have been identified in the heart including the angiotensin II receptor subtypes AT1 and AT2 In the normal human heart, there is a decreasing receptor density from the right atrium to the left ventricle. In right atrial membranes prepared from patho...
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| Veröffentlicht in: | European heart journal 1994-12, Vol.15 (suppl-D), p.98-103 |
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| container_end_page | 103 |
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| container_issue | suppl-D |
| container_start_page | 98 |
| container_title | European heart journal |
| container_volume | 15 |
| creator | De Gasparo, M. Rogg, H. Brink, M. Wang, L. Whitebread, S. Bullock, G. Erne, P. |
| description | All the components of the renin-angiotensin system have been identified in the heart including the angiotensin II receptor subtypes AT1 and AT2 In the normal human heart, there is a decreasing receptor density from the right atrium to the left ventricle. In right atrial membranes prepared from pathological hearts, the percentage of AT1 receptor decreases with the severity of cardiac dysfunction whereas that of AT2 receptor increases. Treatment of hypertrophic rats with AT1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this Ang II receptor subtype. The role of the AT2 receptor is still largely unknown but it may be involved in cell growth and proliferation. The cloning of both AT1 and AT2 receptors as well as the availability of potent and selective antagonists will help us to understand better the functional role of Angiotensin II in cardiovascular disorders. |
| doi_str_mv | 10.1093/eurheartj/15.suppl_D.98 |
| format | Article |
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In right atrial membranes prepared from pathological hearts, the percentage of AT1 receptor decreases with the severity of cardiac dysfunction whereas that of AT2 receptor increases. Treatment of hypertrophic rats with AT1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this Ang II receptor subtype. The role of the AT2 receptor is still largely unknown but it may be involved in cell growth and proliferation. 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In right atrial membranes prepared from pathological hearts, the percentage of AT1 receptor decreases with the severity of cardiac dysfunction whereas that of AT2 receptor increases. Treatment of hypertrophic rats with AT1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this Ang II receptor subtype. The role of the AT2 receptor is still largely unknown but it may be involved in cell growth and proliferation. The cloning of both AT1 and AT2 receptors as well as the availability of potent and selective antagonists will help us to understand better the functional role of Angiotensin II in cardiovascular disorders.</description><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>AT1</subject><subject>AT2 receptor subtype</subject><subject>Cardiomegaly - drug therapy</subject><subject>Cardiomegaly - physiopathology</subject><subject>Heart Atria - drug effects</subject><subject>Heart Atria - physiopathology</subject><subject>heart failure</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - physiopathology</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>human heart</subject><subject>Humans</subject><subject>receptor subtype</subject><subject>Receptors, Angiotensin - classification</subject><subject>Receptors, Angiotensin - drug effects</subject><subject>Receptors, Angiotensin - physiology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EKqXwCYis2KX1xI4fSyj0gSohQUEVG8txHEhJk2AnEv17ghp1NYt7zx3pIHQDeAxYkolt3ZfVrtlOIB77tq4L9TCW4gQNIY6iUDIan6IhBhmHjInNObrwfosxFgzYAA04BwJRNETxXfmZV40tfV4Gy2XwYo2tm8oFr23S7GvrA12mwVS7NNcmmLWlafKqvERnmS68vervCL3NHtfTRbh6ni-nd6vQkIg3YQqgKYWUcmEJBUaMpCI1zPCISgJZiilorBMsQRgmswx0QoEmHSGFSIGM0O1ht3bVT2t9o3a5N7YodGmr1ivOBZaRJF2RH4rGVd47m6na5Tvt9gqw-hemjsIUxKoXpqToyOv-RZvsbHrkekNdHh7y3Df29xhr960YJzxWi82Hmj_BAm_u39Wa_AGSBnqI</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>De Gasparo, M.</creator><creator>Rogg, H.</creator><creator>Brink, M.</creator><creator>Wang, L.</creator><creator>Whitebread, S.</creator><creator>Bullock, G.</creator><creator>Erne, P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Angiotensin II Receptor Subtypes and Cardiac Function</title><author>De Gasparo, M. ; 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| ispartof | European heart journal, 1994-12, Vol.15 (suppl-D), p.98-103 |
| issn | 0195-668X 1522-9645 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals AT1 AT2 receptor subtype Cardiomegaly - drug therapy Cardiomegaly - physiopathology Heart Atria - drug effects Heart Atria - physiopathology heart failure Heart Failure - drug therapy Heart Failure - physiopathology Heart Ventricles - drug effects Heart Ventricles - physiopathology Hemodynamics - drug effects Hemodynamics - physiology human heart Humans receptor subtype Receptors, Angiotensin - classification Receptors, Angiotensin - drug effects Receptors, Angiotensin - physiology |
| title | Angiotensin II Receptor Subtypes and Cardiac Function |
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