Brain-plasma distribution of free and total benzodiazepines in dogs physically dependent on different doses of diazepam

Steady-state levels of oxazepam (OX), nordiazepam (ND), and diazepam (DZ) in plasma, brain tissue, cerebrospinal fluid (CSF), and intracranial microdialysis perfusate were determined in dogs dependent on 0.56, 4.5, 9, and 36 mg/kg per day of DZ. There was a linear relationship between the total plas...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-12, Vol.52 (4), p.707-713
Hauptverfasser:	WALA, E. P, MARTIN, W. R, SLOAN, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Benzodiazepines - pharmacokinetics Biological and medical sciences Brain - metabolism Diazepam - metabolism Dogs Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Female Kinetics Medical sciences Microdialysis Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments
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