Molecular analysis of mutations in mutator colorectal carcinoma cell lines

The nature of mutations occurring in two colorectal carcinoma cell lines deficient in mismatch repair and displaying mutator phenotypes was determined. One of the lines (HCT116) exhibited a higher level of microsatellite instability than the second (DLD-1), although the rate of mutation at the selec...

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Veröffentlicht in:	Human molecular genetics 1995-11, Vol.4 (11), p.2057-2064
Hauptverfasser:	Bhattacharyya, Nitai P., Ganesh, Anil, Phear, Geraldine, Richards, Burt, Skandalis, Adonis, Meuth, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Classical genetics, quantitative genetics, hybrids Colorectal Neoplasms - genetics DNA, Neoplasm DNA, Satellite - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Hypoxanthine Phosphoribosyltransferase - genetics Molecular Sequence Data Mutation Tumor Cells, Cultured
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