Traumatic brain injury reduces hippocampal high-affinity [ 3H]choline uptake but not extracellular choline levels in rats

Hippocampal cholinergic hypofunction may contribute to memory deficits following experimental traumatic brain injury. These studies examined two important factors in acetylcholine synthesis: choline availability and neuronal uptake. No reductions in basal extracellular choline levels, using microdia...

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Veröffentlicht in:	Neuroscience letters 1994-10, Vol.180 (2), p.127-130
Hauptverfasser:	Dixon, C.Edward, Bao, Juliang, Bergmann, John S, Johnson, Kenneth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - biosynthesis Animals Biological and medical sciences Biological Transport Brain Injuries - metabolism Brain Injuries - psychology Brain injury Choline Choline - pharmacokinetics Craniotomy Extracellular Space - metabolism High affinity choline uptake Hippocampus Hippocampus - metabolism Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Memory Disorders - etiology Memory Disorders - physiopathology Microdialysis Neurons - metabolism Rats Traumas. Diseases due to physical agents Wounds, Nonpenetrating - metabolism Wounds, Nonpenetrating - psychology
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