[1] Neoglycoproteins from synthetic glycopeptides
Saccharide side chains of glycoproteins influence the physicochemical properties of the biomacromolecules and their stability against proteolytic degradation. Saccharide side chains of glycoproteins also play important roles as ligands in biological recognition and in the organized distribution of t...
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| Veröffentlicht in: | Methods in Enzymology 1994, Vol.247, p.3-30 |
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| container_title | Methods in Enzymology |
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| creator | Kunz, Horst von dem Bruch, Karsten |
| description | Saccharide side chains of glycoproteins influence the physicochemical properties of the biomacromolecules and their stability against proteolytic degradation. Saccharide side chains of glycoproteins also play important roles as ligands in biological recognition and in the organized distribution of these compounds within multicellular organisms. Carbohydrate-lectin interactions are important, for example, in viral infections and for the recruitment and invasion of leukocytes into injured tissues. Although in a number of processes carbohydrates were revealed to be decisive recognition labels, in other biological selections peptide sequences proved to be the recognized areas. For glycoproteins it seems inappropriate to separate rigorously the role of peptides and carbohydrates because both parts carry a number of polar functionalities predestinated for interacting with one another. Therefore, it is highly presumable that both parts, carbohydrates and peptide sequences, can contribute to a complex recognition label or epitope of a natural glycoprotein. |
| doi_str_mv | 10.1016/S0076-6879(94)47003-0 |
| format | Article |
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Saccharide side chains of glycoproteins also play important roles as ligands in biological recognition and in the organized distribution of these compounds within multicellular organisms. Carbohydrate-lectin interactions are important, for example, in viral infections and for the recruitment and invasion of leukocytes into injured tissues. Although in a number of processes carbohydrates were revealed to be decisive recognition labels, in other biological selections peptide sequences proved to be the recognized areas. For glycoproteins it seems inappropriate to separate rigorously the role of peptides and carbohydrates because both parts carry a number of polar functionalities predestinated for interacting with one another. 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| ispartof | Methods in Enzymology, 1994, Vol.247, p.3-30 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; ScienceDirect eBooks |
| subjects | Amino Acid Sequence Animals Antigens, Tumor-Associated, Carbohydrate - chemistry Carbohydrate Sequence Cattle Disaccharides - chemical synthesis Disaccharides - chemistry Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Glycopeptides - chemical synthesis Glycopeptides - chemistry Glycoproteins - chemical synthesis Glycoproteins - chemistry Models, Chemical Molecular Sequence Data Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry Serum Albumin, Bovine |
| title | [1] Neoglycoproteins from synthetic glycopeptides |
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