Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. Identification of des-arginine 166 erythropoietin

Recombinant human erythropoietin (rhEPO) has been purified to apparent homogeneity from a Chinese hamster ovary cell line expressing a cDNA clone of the human gene. NH2-terminal sequencing of the recombinant hormone indicates that the 27-residue leader peptide is correctly and consistently cleaved d...

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Veröffentlicht in:	The Journal of biological chemistry 1987-12, Vol.262 (35), p.17156-17163
Hauptverfasser:	Recny, M A, Scoble, H A, Kim, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Biotechnology DNA, Recombinant Erythropoietin - genetics Erythropoietin - metabolism Erythropoietin - urine Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Humans Mass Spectrometry Methods. Procedures. Technologies Peptide Fragments - metabolism Peptide Mapping Protein hormones. Growth factors. Cytokines Proteins Vectors (cloning, transfer, expression). Insertion sequences and transposons
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