The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats

Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rat...

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Veröffentlicht in:	Diabetologia 1994-12, Vol.37 (12), p.1209-1215
Hauptverfasser:	CAMERON, N. E, DINES, K. C, COTTER, M. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Associated diseases and complications Biological and medical sciences Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Diabetic Angiopathies - physiopathology Diabetic Neuropathies - physiopathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelin Receptor Antagonists Endothelins - antagonists & inhibitors Endothelins - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Male Medical sciences Motor Neurons - drug effects Motor Neurons - physiology Neural Conduction - drug effects Neurons, Afferent - drug effects Neurons, Afferent - physiology Peptides, Cyclic - pharmacology Peripheral Nerves - drug effects Peripheral Nerves - physiology Peripheral Nerves - physiopathology Rats Rats, Sprague-Dawley Sciatic Nerve - drug effects Sciatic Nerve - physiology Sciatic Nerve - physiopathology Time Factors
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