Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only ∼25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within ∼2- to 3-fold) overall rece...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1994-12, Vol.1 (9), p.793-801
Hauptverfasser:	Linsley, Peter S., Greene, JoAnne L., Brady, William, Bajorath, Jürgen, Ledbetter, Jeffrey A., Peach, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antigens, CD Antigens, Differentiation - chemistry Antigens, Differentiation - genetics Antigens, Differentiation - metabolism B7-1 Antigen - chemistry B7-1 Antigen - metabolism B7-2 Antigen Base Sequence Binding Sites CD28 Antigens - chemistry CD28 Antigens - metabolism CHO Cells Cricetinae CTLA-4 Antigen DNA, Complementary Humans Immunoconjugates Kinetics Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Molecular Sequence Data Recombinant Fusion Proteins - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
Online-Zugang:	Volltext
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