Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats
In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide (oligo) to the rat κ-opioid receptor selectively inhibited κ-mediated analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) AS oligo significantly inhibited the analgesic effect of i.c.v. spira...
Gespeichert in:
| Veröffentlicht in: | Brain research 1994-12, Vol.667 (1), p.129-132 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 132 |
|---|---|
| container_issue | 1 |
| container_start_page | 129 |
| container_title | Brain research |
| container_volume | 667 |
| creator | Adams, Jill U. Chen, Xiaohong DeRiel, J. Kim Adler, Martin W. Liu-Chen, Lee-Yuan |
| description | In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide (oligo) to the rat κ-opioid receptor selectively inhibited κ-mediated analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) AS oligo significantly inhibited the analgesic effect of i.c.v. spiradoline, but not that of μ- or δ-opioid agonists. The dose-effect curve for s.c. spiradoline was shifted to the right after AS, but not missense or sense oligo treatment. Thus, AS oligos provide another technique with which to selectively manipulate opioid receptors and further support the role of non-μ opioid receptors in mediating analgesia in rats. |
| doi_str_mv | 10.1016/0006-8993(94)91723-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77802987</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000689939491723X</els_id><sourcerecordid>77802987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-e627722dc7260b51422e036b90bd2ba787c0358b8380dcac28de0d21547e0a7e3</originalsourceid><addsrcrecordid>eNqFkc2KFDEQgIMo67j6Bgp9EFkPrfnp7iSXBVlWXVjworC3kE5qZkt6kjFJr-5L-EA-hM9k2hnmqBAIVfVVUdRHyHNG3zDKhreU0qFVWosz3b3WTHLR3jwgK6Ykbwfe0YdkdUQekyc5f62hEJqekBOpdE9lvyI_r0JJ1kGCMcU7qAG6ebKpKQls2dZE8x3LbWNDfQUzhAxNnHATPcQf92F2E8SCHpoSm9-_2rjDiL5J4GBXYsoNhlscsYBfqnYTA-bSYvCzqykb7LSBjLZiTbIlPyWP1nbK8Ozwn5Iv7y8_X3xsrz99uLp4d926jsnSwsCl5Nw7yQc69qzjHKgYRk1Hz0crlXRU9GpUQlHvrOPKA_Wc9Z0EaiWIU_JqP3eX4rcZcjFbzA6myQaIczZSKsq1kv8F2TBoJjSvYLcHXYo5J1ibXcKtTfeGUbP4MosMs8gwujN_fZmb2vbiMH8et-CPTQdBtf7yULfZ2WmdbHCYj5gQnZByWfN8j0E92h1CMtkhhHpjrCqK8RH_vccffpO2tA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16691392</pqid></control><display><type>article</type><title>Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Adams, Jill U. ; Chen, Xiaohong ; DeRiel, J. Kim ; Adler, Martin W. ; Liu-Chen, Lee-Yuan</creator><creatorcontrib>Adams, Jill U. ; Chen, Xiaohong ; DeRiel, J. Kim ; Adler, Martin W. ; Liu-Chen, Lee-Yuan</creatorcontrib><description>In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide (oligo) to the rat κ-opioid receptor selectively inhibited κ-mediated analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) AS oligo significantly inhibited the analgesic effect of i.c.v. spiradoline, but not that of μ- or δ-opioid agonists. The dose-effect curve for s.c. spiradoline was shifted to the right after AS, but not missense or sense oligo treatment. Thus, AS oligos provide another technique with which to selectively manipulate opioid receptors and further support the role of non-μ opioid receptors in mediating analgesia in rats.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)91723-X</identifier><identifier>PMID: 7895075</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Analgesia ; Animals ; Antisense ; Base Sequence ; Biological and medical sciences ; Injections, Intraventricular ; Male ; Medical sciences ; Molecular Sequence Data ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Oligodeoxynucleotide ; Oligonucleotides, Antisense - administration & dosage ; Oligonucleotides, Antisense - genetics ; Oligonucleotides, Antisense - pharmacology ; Opioid ; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems ; Pharmacology. Drug treatments ; Pyrrolidines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa - antagonists & inhibitors ; Spiradoline ; κ-opioid receptor</subject><ispartof>Brain research, 1994-12, Vol.667 (1), p.129-132</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e627722dc7260b51422e036b90bd2ba787c0358b8380dcac28de0d21547e0a7e3</citedby><cites>FETCH-LOGICAL-c417t-e627722dc7260b51422e036b90bd2ba787c0358b8380dcac28de0d21547e0a7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)91723-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3343777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7895075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adams, Jill U.</creatorcontrib><creatorcontrib>Chen, Xiaohong</creatorcontrib><creatorcontrib>DeRiel, J. Kim</creatorcontrib><creatorcontrib>Adler, Martin W.</creatorcontrib><creatorcontrib>Liu-Chen, Lee-Yuan</creatorcontrib><title>Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide (oligo) to the rat κ-opioid receptor selectively inhibited κ-mediated analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) AS oligo significantly inhibited the analgesic effect of i.c.v. spiradoline, but not that of μ- or δ-opioid agonists. The dose-effect curve for s.c. spiradoline was shifted to the right after AS, but not missense or sense oligo treatment. Thus, AS oligos provide another technique with which to selectively manipulate opioid receptors and further support the role of non-μ opioid receptors in mediating analgesia in rats.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Antisense</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Oligodeoxynucleotide</subject><subject>Oligonucleotides, Antisense - administration & dosage</subject><subject>Oligonucleotides, Antisense - genetics</subject><subject>Oligonucleotides, Antisense - pharmacology</subject><subject>Opioid</subject><subject>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrrolidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Opioid, kappa - antagonists & inhibitors</subject><subject>Spiradoline</subject><subject>κ-opioid receptor</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQgIMo67j6Bgp9EFkPrfnp7iSXBVlWXVjworC3kE5qZkt6kjFJr-5L-EA-hM9k2hnmqBAIVfVVUdRHyHNG3zDKhreU0qFVWosz3b3WTHLR3jwgK6Ykbwfe0YdkdUQekyc5f62hEJqekBOpdE9lvyI_r0JJ1kGCMcU7qAG6ebKpKQls2dZE8x3LbWNDfQUzhAxNnHATPcQf92F2E8SCHpoSm9-_2rjDiL5J4GBXYsoNhlscsYBfqnYTA-bSYvCzqykb7LSBjLZiTbIlPyWP1nbK8Ozwn5Iv7y8_X3xsrz99uLp4d926jsnSwsCl5Nw7yQc69qzjHKgYRk1Hz0crlXRU9GpUQlHvrOPKA_Wc9Z0EaiWIU_JqP3eX4rcZcjFbzA6myQaIczZSKsq1kv8F2TBoJjSvYLcHXYo5J1ibXcKtTfeGUbP4MosMs8gwujN_fZmb2vbiMH8et-CPTQdBtf7yULfZ2WmdbHCYj5gQnZByWfN8j0E92h1CMtkhhHpjrCqK8RH_vccffpO2tA</recordid><startdate>19941219</startdate><enddate>19941219</enddate><creator>Adams, Jill U.</creator><creator>Chen, Xiaohong</creator><creator>DeRiel, J. Kim</creator><creator>Adler, Martin W.</creator><creator>Liu-Chen, Lee-Yuan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941219</creationdate><title>Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats</title><author>Adams, Jill U. ; Chen, Xiaohong ; DeRiel, J. Kim ; Adler, Martin W. ; Liu-Chen, Lee-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e627722dc7260b51422e036b90bd2ba787c0358b8380dcac28de0d21547e0a7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Antisense</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Oligodeoxynucleotide</topic><topic>Oligonucleotides, Antisense - administration & dosage</topic><topic>Oligonucleotides, Antisense - genetics</topic><topic>Oligonucleotides, Antisense - pharmacology</topic><topic>Opioid</topic><topic>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrrolidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Opioid, kappa - antagonists & inhibitors</topic><topic>Spiradoline</topic><topic>κ-opioid receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, Jill U.</creatorcontrib><creatorcontrib>Chen, Xiaohong</creatorcontrib><creatorcontrib>DeRiel, J. Kim</creatorcontrib><creatorcontrib>Adler, Martin W.</creatorcontrib><creatorcontrib>Liu-Chen, Lee-Yuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, Jill U.</au><au>Chen, Xiaohong</au><au>DeRiel, J. Kim</au><au>Adler, Martin W.</au><au>Liu-Chen, Lee-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-12-19</date><risdate>1994</risdate><volume>667</volume><issue>1</issue><spage>129</spage><epage>132</epage><pages>129-132</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide (oligo) to the rat κ-opioid receptor selectively inhibited κ-mediated analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) AS oligo significantly inhibited the analgesic effect of i.c.v. spiradoline, but not that of μ- or δ-opioid agonists. The dose-effect curve for s.c. spiradoline was shifted to the right after AS, but not missense or sense oligo treatment. Thus, AS oligos provide another technique with which to selectively manipulate opioid receptors and further support the role of non-μ opioid receptors in mediating analgesia in rats.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7895075</pmid><doi>10.1016/0006-8993(94)91723-X</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1994-12, Vol.667 (1), p.129-132 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77802987 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesia Animals Antisense Base Sequence Biological and medical sciences Injections, Intraventricular Male Medical sciences Molecular Sequence Data Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oligodeoxynucleotide Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - pharmacology Opioid Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - antagonists & inhibitors Spiradoline κ-opioid receptor |
| title | Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A04%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intracerebroventricular%20treatment%20with%20an%20antisense%20oligodeoxynucleotide%20to%20%CE%BA-opioid%20receptors%20inhibited%20%CE%BA-agonist-induced%20analgesia%20in%20rats&rft.jtitle=Brain%20research&rft.au=Adams,%20Jill%20U.&rft.date=1994-12-19&rft.volume=667&rft.issue=1&rft.spage=129&rft.epage=132&rft.pages=129-132&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/0006-8993(94)91723-X&rft_dat=%3Cproquest_cross%3E77802987%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16691392&rft_id=info:pmid/7895075&rft_els_id=000689939491723X&rfr_iscdi=true |