O/W Lipid Emulsions for Parenteral Drug Delivery. I. Pharmacokinetics of the Oil Particles and Incorporated Sudan II

The potential usefulness of oil in water (O/W) lipid emulsions as parenteral drug delivery system for lipophilic drugs was examined in tumor-bearing rats. A model lipophilic drug, sudan II (PCoct=226000), was formulated in five lipid emulsions consisting of soybean oil and various surfactants. Compa...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/11/15, Vol.17(11), pp.1490-1495
Hauptverfasser:	SAKAEDA, Toshiyuki, TAKAHASHI, Koji, NISHIHARA, Yoshitaka, HIRANO, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Animals Azo Compounds - administration & dosage Azo Compounds - metabolism Azo Compounds - pharmacokinetics Biological and medical sciences Brain - metabolism Carcinosarcoma - metabolism drug delivery system Drug Delivery Systems Emulsions General pharmacology Injections, Intravenous Kidney - metabolism Liver - metabolism Lung - metabolism Male Medical sciences Models, Biological Muscles - metabolism Myocardium - metabolism O/W lipid emulsion partition coefficient Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Wistar release Sarcoma, Experimental - metabolism Soybean Oil - chemistry Soybean Oil - metabolism Soybean Oil - pharmacokinetics Spleen - metabolism Surface-Active Agents - chemistry Surface-Active Agents - metabolism Tissue Distribution
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