Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage
Background: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few. Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by inser...
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| Veröffentlicht in: | Gastrointestinal endoscopy 1995-11, Vol.42 (5), p.439-444 |
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| creator | Sung, Joseph J.Y. Leung, Joseph C.K. Tsui, C.P. Chung, S.C.Sydney Lai, Kar Neng |
| description | Background: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few.
Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays.
Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction.
Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system. (Gastrointest Endosc 1995;42:439-44.) |
| doi_str_mv | 10.1016/S0016-5107(95)70047-1 |
| format | Article |
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Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays.
Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction.
Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system. (Gastrointest Endosc 1995;42:439-44.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/S0016-5107(95)70047-1</identifier><identifier>PMID: 8566635</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aged ; Bile - immunology ; Bile Duct Neoplasms - complications ; Biological and medical sciences ; Case-Control Studies ; Cholestasis, Extrahepatic - etiology ; Cholestasis, Extrahepatic - immunology ; Cholestasis, Extrahepatic - therapy ; Common Bile Duct Neoplasms - complications ; Diseases of the digestive system ; Drainage ; Enzyme-Linked Immunosorbent Assay ; Female ; Gallstones - complications ; Humans ; Immunoglobulin A - analysis ; Immunoglobulin A - metabolism ; Immunoglobulin A, Secretory - analysis ; Immunoglobulin A, Secretory - metabolism ; Male ; Medical sciences ; Middle Aged ; Pancreatic Neoplasms - complications ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Secretory Component - analysis ; Secretory Component - metabolism</subject><ispartof>Gastrointestinal endoscopy, 1995-11, Vol.42 (5), p.439-444</ispartof><rights>1995 American Society for Gastrointestinal Endoscopy</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-418532aa482936a2188b14952a9f9de8170429428d029ecd8424bd2ef5eb4e573</citedby><cites>FETCH-LOGICAL-c455t-418532aa482936a2188b14952a9f9de8170429428d029ecd8424bd2ef5eb4e573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016510795700471$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2921286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8566635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Joseph J.Y.</creatorcontrib><creatorcontrib>Leung, Joseph C.K.</creatorcontrib><creatorcontrib>Tsui, C.P.</creatorcontrib><creatorcontrib>Chung, S.C.Sydney</creatorcontrib><creatorcontrib>Lai, Kar Neng</creatorcontrib><title>Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few.
Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays.
Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction.
Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system. (Gastrointest Endosc 1995;42:439-44.)</description><subject>Aged</subject><subject>Bile - immunology</subject><subject>Bile Duct Neoplasms - complications</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cholestasis, Extrahepatic - etiology</subject><subject>Cholestasis, Extrahepatic - immunology</subject><subject>Cholestasis, Extrahepatic - therapy</subject><subject>Common Bile Duct Neoplasms - complications</subject><subject>Diseases of the digestive system</subject><subject>Drainage</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gallstones - complications</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Immunoglobulin A, Secretory - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreatic Neoplasms - complications</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Secretory Component - analysis</subject><subject>Secretory Component - metabolism</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMouq7-BCEHET1UkzRpEi-yii8QRNRzSJOpRrrNmrSC_97qLnv1MnOYb14fQgeUnFJCq7NnMsZCUCKPtTiRhHBZ0A00oUTLopJSb6LJGtlBuzl_EEIUK-k22laiqqpSTNDTZWiDTd_4_m2GM7gEfYgdDh2Ode7T4PrwBfjDDp0PDs7xyztgaBpwfcaxwdD5mF1cBId9sqGzb7CHthrbZthf5Sl6vbl-uborHh5v769mD4XjQvQFp0qUzFqumC4ry6hSNeVaMKsb7UFRSTjTnClPmAbnFWe89gwaATUHIcspOlrOXaT4OUDuzTxkB21rO4hDNlIqwsrx3ykSS9ClmHOCxixSmI8_G0rMr0rzp9L8ejJamD-Vho59B6sFQz0Hv-5auRvrh6u6zc62TbKdC3mNMc0oU9WIXSwxGGV8BUgmuwCdAx_SqNH4GP455AcFhI60</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Sung, Joseph J.Y.</creator><creator>Leung, Joseph C.K.</creator><creator>Tsui, C.P.</creator><creator>Chung, S.C.Sydney</creator><creator>Lai, Kar Neng</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage</title><author>Sung, Joseph J.Y. ; Leung, Joseph C.K. ; Tsui, C.P. ; Chung, S.C.Sydney ; Lai, Kar Neng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-418532aa482936a2188b14952a9f9de8170429428d029ecd8424bd2ef5eb4e573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Bile - immunology</topic><topic>Bile Duct Neoplasms - complications</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cholestasis, Extrahepatic - etiology</topic><topic>Cholestasis, Extrahepatic - immunology</topic><topic>Cholestasis, Extrahepatic - therapy</topic><topic>Common Bile Duct Neoplasms - complications</topic><topic>Diseases of the digestive system</topic><topic>Drainage</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gallstones - complications</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Immunoglobulin A, Secretory - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pancreatic Neoplasms - complications</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Secretory Component - analysis</topic><topic>Secretory Component - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Joseph J.Y.</creatorcontrib><creatorcontrib>Leung, Joseph C.K.</creatorcontrib><creatorcontrib>Tsui, C.P.</creatorcontrib><creatorcontrib>Chung, S.C.Sydney</creatorcontrib><creatorcontrib>Lai, Kar Neng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Joseph J.Y.</au><au>Leung, Joseph C.K.</au><au>Tsui, C.P.</au><au>Chung, S.C.Sydney</au><au>Lai, Kar Neng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>42</volume><issue>5</issue><spage>439</spage><epage>444</epage><pages>439-444</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few.
Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays.
Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction.
Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system. (Gastrointest Endosc 1995;42:439-44.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8566635</pmid><doi>10.1016/S0016-5107(95)70047-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Bile - immunology Bile Duct Neoplasms - complications Biological and medical sciences Case-Control Studies Cholestasis, Extrahepatic - etiology Cholestasis, Extrahepatic - immunology Cholestasis, Extrahepatic - therapy Common Bile Duct Neoplasms - complications Diseases of the digestive system Drainage Enzyme-Linked Immunosorbent Assay Female Gallstones - complications Humans Immunoglobulin A - analysis Immunoglobulin A - metabolism Immunoglobulin A, Secretory - analysis Immunoglobulin A, Secretory - metabolism Male Medical sciences Middle Aged Pancreatic Neoplasms - complications Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Secretory Component - analysis Secretory Component - metabolism |
| title | Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage |
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