Studies of the mechanism underlying increased Na+/Ca2+ exchange activity in Alzheimer's disease brain

The Na+/Ca2+ exchanger was characterized in plasma membrane vesicles derived from frozen human postmortem tissues. The frontal cortex, temporal cortex and cerebellum of control and Alzheimer's disease (AD) tissues were compared. Na+/Ca2+ exchange activity was defined as the change in vesicular...

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Veröffentlicht in:	Brain research 1994-12, Vol.665 (2), p.192-200
Hauptverfasser:	COLVIN, R. A, DAVIS, N, ANFAN WU, MURPHY, C. A, LEVENGOOD, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amiloride - analogs & derivatives Amiloride - pharmacology Biological and medical sciences Brain - metabolism Calcium - metabolism Carrier Proteins - metabolism Cell Membrane - metabolism Cerebellum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Kinetics Medical sciences Neurology Peptides - pharmacology Reference Values Sodium-Calcium Exchanger Time Factors Tissue Distribution
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