Gene expression following direct injection of DNA into liver

The liver is an attractive target tissue for gene therapy. Current approaches for hepatic gene delivery include retroviral and adenoviral vectors, liposome/DNA, and peptide/DNA complexes. This study describes a technique for direct injection of DNA into liver that led to significant gene expression....

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Veröffentlicht in:	Human gene therapy 1994-12, Vol.5 (12), p.1477-1483
Hauptverfasser:	Hickman, M A, Malone, R W, Lehmann-Bruinsma, K, Sih, T R, Knoell, D, Szoka, F C, Walzem, R, Carlson, D M, Powell, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - biosynthesis Animals beta-Galactosidase - biosynthesis Cats DNA - administration & dosage Gene Expression Genetic Therapy Humans Injections Liver - metabolism Luciferases - biosynthesis Plasmids Rats Rats, Sprague-Dawley Tumor Cells, Cultured
Online-Zugang:	Volltext
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