Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist

The direct design of the potent nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist, 8-[[[4-(aminoiminomethyl)phenyl]amino]carbonyl]-2,3,4, ( 3) (SB 207448), based on the structure and conformation of the potent and highly constrained cyclic peptide antagonist SK&F 107260 ( 2), has b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1994-09, Vol.2 (9), p.897-908
Hauptverfasser:	Bondinell, William E., Keenan, Richard M., Miller, William H., Ali, Fadia E., Allen, Andrew C., De Brosse, Charles W., Eggleston, Drake S., Erhard, Karl F., Haltiwanger, R.Curtis, Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Koster, Paul F., Ku, Thomas W., Lee, Chao Pin, Nichols, Andrew J., Ross, Stephen T., Samanen, James M., Valocik, Richard E., Vasko-Moser, Janice A., Venslavsky, Joseph W., Wong, Angela S., Yuan, Chuan-Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amino Acid Sequence Animals Benzodiazepinones - chemical synthesis Benzodiazepinones - pharmacology Blood Platelets - chemistry Blood Platelets - ultrastructure Dogs Humans Infusions, Intravenous Kinetics Male Methylation Molecular Sequence Data Molecular Structure Peptides - chemical synthesis Peptides - pharmacology Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - metabolism Platelet Aggregation Inhibitors - pharmacology Platelet Membrane Glycoproteins - antagonists & inhibitors Platelet Membrane Glycoproteins - metabolism Rabbits
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