Design of orally active, non-peptide fibrinogen receptor antagonists. An evolutionary process from the RGD sequence to novel anti-platelet aggregation agents

The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb–IIIa (integrin α IIbβ 3). This work concentrates on the replace...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1994-09, Vol.2 (9), p.881-895
Hauptverfasser:	Bovy, P.R., Tjoeng, F.S., Rico, J.G., Rogers, T.E., Lindmark, R.J., Zablocki, J.A., Garland, R.B., McMackins, D.E., Dayringer, H., Tóth, M.V., Zupec, M.E., Rao, S., Panzer-Knodle, S.G., Nicholson, N.S., Salyers, A., Taite, B.B., Herin, M., Miyano, M., Feigen, L.P., Adams, S.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amino Acid Sequence Animals Benzamidines - chemical synthesis Benzamidines - pharmacology Dogs Female Male Molecular Sequence Data Oligopeptides - pharmacology Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Platelet Membrane Glycoproteins - antagonists & inhibitors Structure-Activity Relationship
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