Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease

DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimiz...

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Veröffentlicht in:	Neuroreport 1994-12, Vol.6 (1), p.49-53
Hauptverfasser:	Horellou, Philippe, Vigne, Emmanuelle, Castel, Marie-Noëlle, Barnéoud, Pascal, Colin, Philippe, Perricaudet, Michel, Delaère, Pia, Mallet, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - physiology adenovirus Animals Apomorphine - pharmacology Behavior, Animal - drug effects beta-Galactosidase - genetics Biological and medical sciences Brain - physiopathology Corpus Striatum - drug effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Denervation Female Gene Transfer Techniques Genetic Vectors Medical sciences Neurology Oxidopamine - pharmacology Parkinson Disease - genetics Parkinson Disease - therapy Rats Rats, Sprague-Dawley Recombination, Genetic Stereotyped Behavior Tyrosine 3-Monooxygenase - genetics
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