Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease
DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimiz...
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| Veröffentlicht in: | Neuroreport 1994-12, Vol.6 (1), p.49-53 |
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| container_title | Neuroreport |
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| creator | Horellou, Philippe Vigne, Emmanuelle Castel, Marie-Noëlle Barnéoud, Pascal Colin, Philippe Perricaudet, Michel Delaère, Pia Mallet, Jacques |
| description | DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One, and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase, and not by a control adenovirus encoding β-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes. |
| doi_str_mv | 10.1097/00001756-199412300-00014 |
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To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One, and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase, and not by a control adenovirus encoding β-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199412300-00014</identifier><identifier>PMID: 7703427</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adenoviridae - physiology ; adenovirus ; Animals ; Apomorphine - pharmacology ; Behavior, Animal - drug effects ; beta-Galactosidase - genetics ; Biological and medical sciences ; Brain - physiopathology ; Corpus Striatum - drug effects ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Denervation ; Female ; Gene Transfer Techniques ; Genetic Vectors ; Medical sciences ; Neurology ; Oxidopamine - pharmacology ; Parkinson Disease - genetics ; Parkinson Disease - therapy ; Rats ; Rats, Sprague-Dawley ; Recombination, Genetic ; Stereotyped Behavior ; Tyrosine 3-Monooxygenase - genetics</subject><ispartof>Neuroreport, 1994-12, Vol.6 (1), p.49-53</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4154-ddc463f18b98d04165345956416512d56081f8b59bf3101f3c55ca1882f3abfa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3395119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7703427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horellou, Philippe</creatorcontrib><creatorcontrib>Vigne, Emmanuelle</creatorcontrib><creatorcontrib>Castel, Marie-Noëlle</creatorcontrib><creatorcontrib>Barnéoud, Pascal</creatorcontrib><creatorcontrib>Colin, Philippe</creatorcontrib><creatorcontrib>Perricaudet, Michel</creatorcontrib><creatorcontrib>Delaère, Pia</creatorcontrib><creatorcontrib>Mallet, Jacques</creatorcontrib><title>Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One, and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase, and not by a control adenovirus encoding β-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.</description><subject>Adenoviridae - physiology</subject><subject>adenovirus</subject><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>beta-Galactosidase - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Corpus Striatum - drug effects</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Denervation</subject><subject>Female</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Vectors</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Oxidopamine - pharmacology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recombination, Genetic</subject><subject>Stereotyped Behavior</subject><subject>Tyrosine 3-Monooxygenase - genetics</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9uEzEQxi1EVULhEZB8QNwWPLG9ax9R-StVgkORuFle77hZ6tjB3rTNkffiCfpUeEmaG8IXj2Z-3zeyPhNCgb0Gprs3rB7oZNuA1gKWnLFm7ohHZAGi442U6vtjsmBa6kboVj4hT0v5URHNQJ2S065jXCy7Bfn1bszoJjrGKVuHGftsA73CiLQ2YvGYafLURmoHjOlmnMc3VZEyxbtNxlLGeEWnXU61QLraDTnd7YItWD2ppdlOdJ0GDLPNV5uvx1hSvP9d6DAWrNgzcuJtKPj8cJ-Rbx_eX55_ai6-fPx8_vaicQKkaIbBiZZ7UL1WAxPQSi6klu1cwXKQLVPgVS917zkw8NxJ6SwotfTc9t7yM_Jq77vJ6ecWy2TWY3EYgo2YtsV0Xae10vK_ILStkLxVFVR70NXHl4zebPK4tnlngJk5JvMQkznGZP7GVKUvDju2_RqHo_CQS52_PMxtcTb4GoUbyxHjXEsAXTGxx25TmDCX67C9xWxWaMO0Mv_6JPwP8KGsIQ</recordid><startdate>19941230</startdate><enddate>19941230</enddate><creator>Horellou, Philippe</creator><creator>Vigne, Emmanuelle</creator><creator>Castel, Marie-Noëlle</creator><creator>Barnéoud, Pascal</creator><creator>Colin, Philippe</creator><creator>Perricaudet, Michel</creator><creator>Delaère, Pia</creator><creator>Mallet, Jacques</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941230</creationdate><title>Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease</title><author>Horellou, Philippe ; Vigne, Emmanuelle ; Castel, Marie-Noëlle ; Barnéoud, Pascal ; Colin, Philippe ; Perricaudet, Michel ; Delaère, Pia ; Mallet, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4154-ddc463f18b98d04165345956416512d56081f8b59bf3101f3c55ca1882f3abfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenoviridae - physiology</topic><topic>adenovirus</topic><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>beta-Galactosidase - genetics</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Corpus Striatum - drug effects</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Denervation</topic><topic>Female</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Vectors</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Oxidopamine - pharmacology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recombination, Genetic</topic><topic>Stereotyped Behavior</topic><topic>Tyrosine 3-Monooxygenase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horellou, Philippe</creatorcontrib><creatorcontrib>Vigne, Emmanuelle</creatorcontrib><creatorcontrib>Castel, Marie-Noëlle</creatorcontrib><creatorcontrib>Barnéoud, Pascal</creatorcontrib><creatorcontrib>Colin, Philippe</creatorcontrib><creatorcontrib>Perricaudet, Michel</creatorcontrib><creatorcontrib>Delaère, Pia</creatorcontrib><creatorcontrib>Mallet, Jacques</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horellou, Philippe</au><au>Vigne, Emmanuelle</au><au>Castel, Marie-Noëlle</au><au>Barnéoud, Pascal</au><au>Colin, Philippe</au><au>Perricaudet, Michel</au><au>Delaère, Pia</au><au>Mallet, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1994-12-30</date><risdate>1994</risdate><volume>6</volume><issue>1</issue><spage>49</spage><epage>53</epage><pages>49-53</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase, and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One, and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase, and not by a control adenovirus encoding β-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7703427</pmid><doi>10.1097/00001756-199412300-00014</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroreport, 1994-12, Vol.6 (1), p.49-53 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenoviridae - physiology adenovirus Animals Apomorphine - pharmacology Behavior, Animal - drug effects beta-Galactosidase - genetics Biological and medical sciences Brain - physiopathology Corpus Striatum - drug effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Denervation Female Gene Transfer Techniques Genetic Vectors Medical sciences Neurology Oxidopamine - pharmacology Parkinson Disease - genetics Parkinson Disease - therapy Rats Rats, Sprague-Dawley Recombination, Genetic Stereotyped Behavior Tyrosine 3-Monooxygenase - genetics |
| title | Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease |
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