Subunit- and brain region-specific reduction of GABAA receptor subunit mRNAs during chronic treatment of rats with diazepam

The mRNA levels for several GABAA receptor subunits were measured by Northern blot analysis. Rats were treated for 3 wk by continuous release of diazepam (DZP) from subcutaneous reservoirs, and then sacrificed immediately or 48 h after removing the reservoirs. Poly(A)+ RNAs, isolated from cerebral c...

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Veröffentlicht in:	Journal of molecular neuroscience 1994-06, Vol.5 (2), p.105-120
Hauptverfasser:	Wu, Y, Rosenberg, H C, Chiu, T H, Zhao, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Benzodiazepines - pharmacology Blotting, Northern Brain Cerebral Cortex - physiology Diazepam - pharmacology Hippocampus - physiology Male Rats Rats, Sprague-Dawley Receptors, GABA-A - genetics RNA, Messenger - genetics
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