Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis
We have used the severe combined immunodeficient C.B-17- scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite, Brugia malayi. C.B-17- scid/scid mice are permissive...
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| Veröffentlicht in: | Acta tropica 1994-12, Vol.58 (3), p.283-289 |
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| creator | Rajan, T.V. Bailis, Julie M. Yates, Jon A. Shultz, Leonard D. Greiner, Dale L. Kenneth Nelson, F. |
| description | We have used the severe combined immunodeficient C.B-17-
scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite,
Brugia malayi. C.B-17-
scid/scid mice are permissive for infection while immunocompetent C.B-17-+/+ mice are uniformly resistant. Reciprocal matings of C.B-17-
scid/scid and C.B-17-+/+ mice were performed. The C.B-17-
scid/scid females were either naive or infected with
Brugia malayi. The resulting immunocompetent C.B-17-
scid/+ and C.B-17-+/
scid progeny were challenged at weaning with an intraperitoneal injection of
Brugia malayi third stage larvae known to produce patent infection in >95 of C.B-17-
scid/scid mice. We observed that 40.0% (
34
85
) of the immunocompetent offspring of C.B-17-
scid/
scid females × C.B-17-+/+ males were permissive for the growth and development of
Brugia malayi larvae to adults. No difference was observed in susceptibility to infection between the progeny of infected or uninfected C.B-17-
scid/scid mothers mated with C.B-17-+/+ fathers, arguing against acquired immunological tolerance to the parasite in the former. In marked contrast, only 4.8% (
2
42
) of the heterozygous progeny of wild type C.B-17-+/+ females mated with C.B-17-
scid/scid males were permissive. These observations document conversion of a ‘resistant’ phenotype to a ‘susceptible’ phenotype by manipulation of maternal immune status and provide clear evidence of maternal influence on offspring susceptibility to infection with
Brugia malayi. |
| doi_str_mv | 10.1016/0001-706X(94)90022-1 |
| format | Article |
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scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite,
Brugia malayi. C.B-17-
scid/scid mice are permissive for infection while immunocompetent C.B-17-+/+ mice are uniformly resistant. Reciprocal matings of C.B-17-
scid/scid and C.B-17-+/+ mice were performed. The C.B-17-
scid/scid females were either naive or infected with
Brugia malayi. The resulting immunocompetent C.B-17-
scid/+ and C.B-17-+/
scid progeny were challenged at weaning with an intraperitoneal injection of
Brugia malayi third stage larvae known to produce patent infection in >95 of C.B-17-
scid/scid mice. We observed that 40.0% (
34
85
) of the immunocompetent offspring of C.B-17-
scid/
scid females × C.B-17-+/+ males were permissive for the growth and development of
Brugia malayi larvae to adults. No difference was observed in susceptibility to infection between the progeny of infected or uninfected C.B-17-
scid/scid mothers mated with C.B-17-+/+ fathers, arguing against acquired immunological tolerance to the parasite in the former. In marked contrast, only 4.8% (
2
42
) of the heterozygous progeny of wild type C.B-17-+/+ females mated with C.B-17-
scid/scid males were permissive. These observations document conversion of a ‘resistant’ phenotype to a ‘susceptible’ phenotype by manipulation of maternal immune status and provide clear evidence of maternal influence on offspring susceptibility to infection with
Brugia malayi.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/0001-706X(94)90022-1</identifier><identifier>PMID: 7709867</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alleles ; Animals ; Animals, Newborn - immunology ; Brugia malayi ; Brugia malayi - immunology ; Female ; Filariasis - genetics ; Filariasis - immunology ; Filariasis - parasitology ; Genetic Predisposition to Disease ; Immunity, Maternally-Acquired - genetics ; Lymphatic filariasis ; Male ; Mice ; Mice, SCID ; scid Mouse</subject><ispartof>Acta tropica, 1994-12, Vol.58 (3), p.283-289</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-76f489f8146c044b64763f9b36f24e85cd7ab8a116527ca2c3a7768d8779c83</citedby><cites>FETCH-LOGICAL-c434t-76f489f8146c044b64763f9b36f24e85cd7ab8a116527ca2c3a7768d8779c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0001-706X(94)90022-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7709867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajan, T.V.</creatorcontrib><creatorcontrib>Bailis, Julie M.</creatorcontrib><creatorcontrib>Yates, Jon A.</creatorcontrib><creatorcontrib>Shultz, Leonard D.</creatorcontrib><creatorcontrib>Greiner, Dale L.</creatorcontrib><creatorcontrib>Kenneth Nelson, F.</creatorcontrib><title>Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>We have used the severe combined immunodeficient C.B-17-
scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite,
Brugia malayi. C.B-17-
scid/scid mice are permissive for infection while immunocompetent C.B-17-+/+ mice are uniformly resistant. Reciprocal matings of C.B-17-
scid/scid and C.B-17-+/+ mice were performed. The C.B-17-
scid/scid females were either naive or infected with
Brugia malayi. The resulting immunocompetent C.B-17-
scid/+ and C.B-17-+/
scid progeny were challenged at weaning with an intraperitoneal injection of
Brugia malayi third stage larvae known to produce patent infection in >95 of C.B-17-
scid/scid mice. We observed that 40.0% (
34
85
) of the immunocompetent offspring of C.B-17-
scid/
scid females × C.B-17-+/+ males were permissive for the growth and development of
Brugia malayi larvae to adults. No difference was observed in susceptibility to infection between the progeny of infected or uninfected C.B-17-
scid/scid mothers mated with C.B-17-+/+ fathers, arguing against acquired immunological tolerance to the parasite in the former. In marked contrast, only 4.8% (
2
42
) of the heterozygous progeny of wild type C.B-17-+/+ females mated with C.B-17-
scid/scid males were permissive. These observations document conversion of a ‘resistant’ phenotype to a ‘susceptible’ phenotype by manipulation of maternal immune status and provide clear evidence of maternal influence on offspring susceptibility to infection with
Brugia malayi.</description><subject>Alleles</subject><subject>Animals</subject><subject>Animals, Newborn - immunology</subject><subject>Brugia malayi</subject><subject>Brugia malayi - immunology</subject><subject>Female</subject><subject>Filariasis - genetics</subject><subject>Filariasis - immunology</subject><subject>Filariasis - parasitology</subject><subject>Genetic Predisposition to Disease</subject><subject>Immunity, Maternally-Acquired - genetics</subject><subject>Lymphatic filariasis</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>scid Mouse</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9LHDEYh0OpbFfbb1AhJ7GH0SSTyZ-L0C61CoqHevAWMplEXsnMbJMZYb-9me7isYVASN7n94Y8L0JfKbmghIpLQgitJBFP55p_04QwVtEPaE2VrCvBGv4Rrd-RT-g455dyYrJhK7SSkmgl5BrFezv5NNiIYQhx9oPzeBxwnrPz2wlaiDDt8BjKCnmbYHjG04h_pPkZLO5ttDtYkt5NUGIw4HI7F8zjfux8XJIBok1gM-TP6CjYmP2Xw36Cfl__fNzcVHcPv2433-8qx2s-VVIErnRQlAtHOG8Fl6IOuq1FYNyrxnXStspSKhomnWWutlIK1SkptVP1CTrbd92m8c_s82R6KL-J0Q5-nLORBVNakP-CNWuoYJoWkO9Bl8ackw-mmOht2hlKzDILs4g2i2ijufk7C7PETg_957b33XvoIL_Ur_Z1X1y8gk8mO1gm0EEqQk03wr8feAMVZpld</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Rajan, T.V.</creator><creator>Bailis, Julie M.</creator><creator>Yates, Jon A.</creator><creator>Shultz, Leonard D.</creator><creator>Greiner, Dale L.</creator><creator>Kenneth Nelson, F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis</title><author>Rajan, T.V. ; Bailis, Julie M. ; Yates, Jon A. ; Shultz, Leonard D. ; Greiner, Dale L. ; Kenneth Nelson, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-76f489f8146c044b64763f9b36f24e85cd7ab8a116527ca2c3a7768d8779c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Animals, Newborn - immunology</topic><topic>Brugia malayi</topic><topic>Brugia malayi - immunology</topic><topic>Female</topic><topic>Filariasis - genetics</topic><topic>Filariasis - immunology</topic><topic>Filariasis - parasitology</topic><topic>Genetic Predisposition to Disease</topic><topic>Immunity, Maternally-Acquired - genetics</topic><topic>Lymphatic filariasis</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>scid Mouse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajan, T.V.</creatorcontrib><creatorcontrib>Bailis, Julie M.</creatorcontrib><creatorcontrib>Yates, Jon A.</creatorcontrib><creatorcontrib>Shultz, Leonard D.</creatorcontrib><creatorcontrib>Greiner, Dale L.</creatorcontrib><creatorcontrib>Kenneth Nelson, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajan, T.V.</au><au>Bailis, Julie M.</au><au>Yates, Jon A.</au><au>Shultz, Leonard D.</au><au>Greiner, Dale L.</au><au>Kenneth Nelson, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>58</volume><issue>3</issue><spage>283</spage><epage>289</epage><pages>283-289</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>We have used the severe combined immunodeficient C.B-17-
scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite,
Brugia malayi. C.B-17-
scid/scid mice are permissive for infection while immunocompetent C.B-17-+/+ mice are uniformly resistant. Reciprocal matings of C.B-17-
scid/scid and C.B-17-+/+ mice were performed. The C.B-17-
scid/scid females were either naive or infected with
Brugia malayi. The resulting immunocompetent C.B-17-
scid/+ and C.B-17-+/
scid progeny were challenged at weaning with an intraperitoneal injection of
Brugia malayi third stage larvae known to produce patent infection in >95 of C.B-17-
scid/scid mice. We observed that 40.0% (
34
85
) of the immunocompetent offspring of C.B-17-
scid/
scid females × C.B-17-+/+ males were permissive for the growth and development of
Brugia malayi larvae to adults. No difference was observed in susceptibility to infection between the progeny of infected or uninfected C.B-17-
scid/scid mothers mated with C.B-17-+/+ fathers, arguing against acquired immunological tolerance to the parasite in the former. In marked contrast, only 4.8% (
2
42
) of the heterozygous progeny of wild type C.B-17-+/+ females mated with C.B-17-
scid/scid males were permissive. These observations document conversion of a ‘resistant’ phenotype to a ‘susceptible’ phenotype by manipulation of maternal immune status and provide clear evidence of maternal influence on offspring susceptibility to infection with
Brugia malayi.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7709867</pmid><doi>10.1016/0001-706X(94)90022-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-706X |
| ispartof | Acta tropica, 1994-12, Vol.58 (3), p.283-289 |
| issn | 0001-706X 1873-6254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77798960 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alleles Animals Animals, Newborn - immunology Brugia malayi Brugia malayi - immunology Female Filariasis - genetics Filariasis - immunology Filariasis - parasitology Genetic Predisposition to Disease Immunity, Maternally-Acquired - genetics Lymphatic filariasis Male Mice Mice, SCID scid Mouse |
| title | Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis |
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