β-Amyloid precursor protein isoforms show correlations with neurones but not with glia of demented subjects

Post-mortem cerebral cortex from 15 demented patients was specially collected to minimise autolysis and two membrane fractions and one soluble fraction were quantitatively examined for the major species of beta-amyloid precursor protein (APP) of high apparent molecular mass (> or = 80 kDa) togeth...

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Veröffentlicht in:	Acta neuropathologica 1994-12, Vol.88 (6), p.545-552
Hauptverfasser:	PROCTER, A. W, FRANCIS, P. T, BOWEN, D. M, HOLMES, C, WEBSTER, M.-T, QUME, M, STRATMANN, G. C, DOSHI, R, MANN, D. M. A, HARRISON, P. J, PEARSON, R. C. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Biological and medical sciences Cerebral Cortex - metabolism Cerebral Cortex - pathology Dementia - metabolism Dementia - pathology Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neuroglia - metabolism Neuroglia - pathology Neurology Neurons - metabolism RNA, Messenger - metabolism
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