The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
The gene for the mouse Fas ligand was cloned and its chromosomal position determined. Fasl was tightly linked to gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family of ligands, the 0x40 ligand (0 x401,1 crossover in 567 meioti...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1994-05, Vol.1 (2), p.131-136 |
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| creator | Lynch, David H. Watson, Mark L. Alderson, Mark R. Baum, Peter R. Miller, Robert E. Tough, Teresa Gibson, Marylou Davis-Smith, Terri Smiths, Craig A. Hunter, Kent Bhat, Deepti Din, Wenie Goodwin, Raymond G. Seldin, Michael F. |
| description | The gene for the mouse
Fas ligand was cloned and its chromosomal position determined.
Fasl was tightly linked to
gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family of ligands, the 0x40 ligand (0
x401,1 crossover in 567 meiotic events). Southern blot analysis did not reveal any difference between the
Fasl gene from
gld and wild-type mice and levels of
Fasl mRNA transcripts were similar in PMA and ionomycin induced wild-type and coisogenic
gld T cells. Sequence analysis of the
gld gene indicated a single amino acid change (Phe Leu) in the COOH terminal portion of this type II transmembrane protein, and COS cells transfected with
Fasl cDNA from
gld mice failed to induce apoptosis of Fas-expressing target cells. Thus, the data demonstrate that the
gld phenotype is the result of a point mutation in the
Fasl gene and that
Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome |
| doi_str_mv | 10.1016/1074-7613(94)90106-6 |
| format | Article |
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Fas ligand was cloned and its chromosomal position determined.
Fasl was tightly linked to
gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family of ligands, the 0x40 ligand (0
x401,1 crossover in 567 meiotic events). Southern blot analysis did not reveal any difference between the
Fasl gene from
gld and wild-type mice and levels of
Fasl mRNA transcripts were similar in PMA and ionomycin induced wild-type and coisogenic
gld T cells. Sequence analysis of the
gld gene indicated a single amino acid change (Phe Leu) in the COOH terminal portion of this type II transmembrane protein, and COS cells transfected with
Fasl cDNA from
gld mice failed to induce apoptosis of Fas-expressing target cells. Thus, the data demonstrate that the
gld phenotype is the result of a point mutation in the
Fasl gene and that
Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/1074-7613(94)90106-6</identifier><identifier>PMID: 7889405</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Autoimmune Diseases - genetics ; Base Sequence ; Cell Line ; Chromosome Mapping ; Cloning, Molecular ; DNA - genetics ; Fas Ligand Protein ; Genetic Linkage ; Membrane Glycoproteins - genetics ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Molecular Sequence Data ; Multigene Family ; Phenotype ; Point Mutation ; Transfection ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>Immunity (Cambridge, Mass.), 1994-05, Vol.1 (2), p.131-136</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-6812bb7956ff6833939418f262eb4b3c71ff9ba3641eac43c5736645cb29749d3</citedby><cites>FETCH-LOGICAL-c454t-6812bb7956ff6833939418f262eb4b3c71ff9ba3641eac43c5736645cb29749d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1074-7613(94)90106-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7889405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, David H.</creatorcontrib><creatorcontrib>Watson, Mark L.</creatorcontrib><creatorcontrib>Alderson, Mark R.</creatorcontrib><creatorcontrib>Baum, Peter R.</creatorcontrib><creatorcontrib>Miller, Robert E.</creatorcontrib><creatorcontrib>Tough, Teresa</creatorcontrib><creatorcontrib>Gibson, Marylou</creatorcontrib><creatorcontrib>Davis-Smith, Terri</creatorcontrib><creatorcontrib>Smiths, Craig A.</creatorcontrib><creatorcontrib>Hunter, Kent</creatorcontrib><creatorcontrib>Bhat, Deepti</creatorcontrib><creatorcontrib>Din, Wenie</creatorcontrib><creatorcontrib>Goodwin, Raymond G.</creatorcontrib><creatorcontrib>Seldin, Michael F.</creatorcontrib><title>The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>The gene for the mouse
Fas ligand was cloned and its chromosomal position determined.
Fasl was tightly linked to
gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family of ligands, the 0x40 ligand (0
x401,1 crossover in 567 meiotic events). Southern blot analysis did not reveal any difference between the
Fasl gene from
gld and wild-type mice and levels of
Fasl mRNA transcripts were similar in PMA and ionomycin induced wild-type and coisogenic
gld T cells. Sequence analysis of the
gld gene indicated a single amino acid change (Phe Leu) in the COOH terminal portion of this type II transmembrane protein, and COS cells transfected with
Fasl cDNA from
gld mice failed to induce apoptosis of Fas-expressing target cells. Thus, the data demonstrate that the
gld phenotype is the result of a point mutation in the
Fasl gene and that
Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Autoimmune Diseases - genetics</subject><subject>Base Sequence</subject><subject>Cell Line</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>DNA - genetics</subject><subject>Fas Ligand Protein</subject><subject>Genetic Linkage</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Phenotype</subject><subject>Point Mutation</subject><subject>Transfection</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMovv-BQlaii2rSpEmzEUQcFUQ348JVSNObMdLHmLTC_HtTZ3Cpq3vhnHMfH0InlFxSQsUVJZJnUlB2rviFIpSITGyhfUqUzDgtyfbUbyx76CDGD0IoLxTZRbuyLBUnxT56m78DbvsxAnYmZo1fmK7GC-gA-4jbcTAD1Nh3eNHUuPUW8KQnaWnCgHuHDZ4_z1K29c1qnbPNGAcIR2jHmSbC8aYeotfZ3fz2IXt6uX-8vXnKLC_4kImS5lUlVSGcEyVjiql0vMtFDhWvmJXUOVUZJjgFYzmzhWRC8MJWuZJc1ewQna3nLkP_OUIcdOujhaYxHaS_tJRSlYnOv0YqEsScsGTka6MNfYwBnF4G35qw0pToCb2euOqJq1Zc_6DXIsVON_PHqoX6N7RhnfTrtQ6JxpeHoKP10FmofQA76Lr3fy_4BkVukDg</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Lynch, David H.</creator><creator>Watson, Mark L.</creator><creator>Alderson, Mark R.</creator><creator>Baum, Peter R.</creator><creator>Miller, Robert E.</creator><creator>Tough, Teresa</creator><creator>Gibson, Marylou</creator><creator>Davis-Smith, Terri</creator><creator>Smiths, Craig A.</creator><creator>Hunter, Kent</creator><creator>Bhat, Deepti</creator><creator>Din, Wenie</creator><creator>Goodwin, Raymond G.</creator><creator>Seldin, Michael F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster</title><author>Lynch, David H. ; Watson, Mark L. ; Alderson, Mark R. ; Baum, Peter R. ; Miller, Robert E. ; Tough, Teresa ; Gibson, Marylou ; Davis-Smith, Terri ; Smiths, Craig A. ; Hunter, Kent ; Bhat, Deepti ; Din, Wenie ; Goodwin, Raymond G. ; Seldin, Michael F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-6812bb7956ff6833939418f262eb4b3c71ff9ba3641eac43c5736645cb29749d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Autoimmune Diseases - genetics</topic><topic>Base Sequence</topic><topic>Cell Line</topic><topic>Chromosome Mapping</topic><topic>Cloning, Molecular</topic><topic>DNA - genetics</topic><topic>Fas Ligand Protein</topic><topic>Genetic Linkage</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Phenotype</topic><topic>Point Mutation</topic><topic>Transfection</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, David H.</creatorcontrib><creatorcontrib>Watson, Mark L.</creatorcontrib><creatorcontrib>Alderson, Mark R.</creatorcontrib><creatorcontrib>Baum, Peter R.</creatorcontrib><creatorcontrib>Miller, Robert E.</creatorcontrib><creatorcontrib>Tough, Teresa</creatorcontrib><creatorcontrib>Gibson, Marylou</creatorcontrib><creatorcontrib>Davis-Smith, Terri</creatorcontrib><creatorcontrib>Smiths, Craig A.</creatorcontrib><creatorcontrib>Hunter, Kent</creatorcontrib><creatorcontrib>Bhat, Deepti</creatorcontrib><creatorcontrib>Din, Wenie</creatorcontrib><creatorcontrib>Goodwin, Raymond G.</creatorcontrib><creatorcontrib>Seldin, Michael F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, David H.</au><au>Watson, Mark L.</au><au>Alderson, Mark R.</au><au>Baum, Peter R.</au><au>Miller, Robert E.</au><au>Tough, Teresa</au><au>Gibson, Marylou</au><au>Davis-Smith, Terri</au><au>Smiths, Craig A.</au><au>Hunter, Kent</au><au>Bhat, Deepti</au><au>Din, Wenie</au><au>Goodwin, Raymond G.</au><au>Seldin, Michael F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>1</volume><issue>2</issue><spage>131</spage><epage>136</epage><pages>131-136</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>The gene for the mouse
Fas ligand was cloned and its chromosomal position determined.
Fasl was tightly linked to
gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family of ligands, the 0x40 ligand (0
x401,1 crossover in 567 meiotic events). Southern blot analysis did not reveal any difference between the
Fasl gene from
gld and wild-type mice and levels of
Fasl mRNA transcripts were similar in PMA and ionomycin induced wild-type and coisogenic
gld T cells. Sequence analysis of the
gld gene indicated a single amino acid change (Phe Leu) in the COOH terminal portion of this type II transmembrane protein, and COS cells transfected with
Fasl cDNA from
gld mice failed to induce apoptosis of Fas-expressing target cells. Thus, the data demonstrate that the
gld phenotype is the result of a point mutation in the
Fasl gene and that
Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7889405</pmid><doi>10.1016/1074-7613(94)90106-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1074-7613 |
| ispartof | Immunity (Cambridge, Mass.), 1994-05, Vol.1 (2), p.131-136 |
| issn | 1074-7613 1097-4180 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77798010 |
| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Autoimmune Diseases - genetics Base Sequence Cell Line Chromosome Mapping Cloning, Molecular DNA - genetics Fas Ligand Protein Genetic Linkage Membrane Glycoproteins - genetics Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular Sequence Data Multigene Family Phenotype Point Mutation Transfection Tumor Necrosis Factor-alpha - genetics |
| title | The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster |
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