Role of vacuolar adenosine triphosphatase in the regulation of cytosolic pH in hepatocytes

The responses of the cytosolic pH of hepatocytes in suspension to agents affecting the activity of vacuolar adenosine triphosphatase (V-ATPase) and Na/H exchange have been studied. Changes of cytosolic pH were determined both with dual-wavelength excitation (500/440 nm) of the fluorescence of 2'...

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Veröffentlicht in:	The Journal of membrane biology 1994-10, Vol.142 (1), p.21-34
Hauptverfasser:	Wadsworth, S J, van Rossum, G D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Animals Anti-Bacterial Agents - pharmacology Carbon Dioxide - pharmacology Chloride Channels - drug effects Chloride Channels - metabolism Chlorides - metabolism Chlorides - pharmacology Endocytosis Fluorescent Dyes Hydrogen-Ion Concentration Intracellular Fluid - chemistry Intracellular Membranes - metabolism Liver - metabolism Macrolides Male Membrane Potentials - drug effects Nitrates - pharmacology Ouabain - pharmacology Proton-Translocating ATPases - antagonists & inhibitors Proton-Translocating ATPases - physiology Protons Rats Rats, Sprague-Dawley Sodium-Hydrogen Exchangers - drug effects Sodium-Hydrogen Exchangers - physiology Vacuoles - enzymology
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